2 results about "Histone demethylation" patented technology

This invention relates to the field of anti-aging drug technology, specifically to the application of small molecule compounds in the preparation of anti-aging drugs. These small molecule compounds competitively block the interaction between KDM6A and the vacuolar ATPase V0 domain subunit ATP6V0C by targeting a specific small molecule binding pocket of the histone demethylase KDM6A, thereby inhibiting the demethylation activity of KDM6A on lysine residue 36 of ATP6V0C. These small molecule compounds can effectively downregulate aging-related β-galactosidase activity, improve cell cycle arrest, and reverse the senescent phenotype of nerve cells induced by the environmental pollutant GenX, making them particularly suitable for combating premature aging of nerve cells induced by perfluorinated and polyfluoroalkyl compounds such as GenX. This technical solution can solve the technical problem of the lack of drugs with clearly defined components, a clear mechanism of action, stable efficacy, and the ability to specifically alleviate aging in existing technologies, and has ideal prospects for widespread application.

The application relates to the field of biotechnology and plant molecular breeding, and discloses a tomato JMJC1 gene in improving the resistance of plants to plant parasitic nematodes. The JMJC1 nucleotide sequence of the gene is shown as SEQ ID NO. 1, and the amino acid sequence of the encoded protein is shown as SEQ ID NO. 2. Research proves that, JMJC1 the gene is strongly induced and expressed by root-knot nematodes, the encoded protein has histone demethylase activity, can specifically remove H3K9me3 and H3K27me3 inhibitory methylation modification, thereby removing the inhibition on downstream resistance-related genes, and activating the high expression of defense genes (such as PDF , PI2 and the like). Phenotype identification shows that overexpression of the JMJC1 gene in tomatoes can significantly reduce the number of root knots, and greatly enhance the defense response and resistance of plants to southern root-knot nematodes.