Purpose of modified thymosin beta 4 in respect of treating diabetic peripheral neuropathy

A technology of peripheral neuropathy and thymosin, which is applied in the field of disease treatment, can solve problems such as diabetic peripheral neuropathy that cannot be cured

Active Publication Date: 2019-06-11
BEIJING NORTHLAND BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment of diabetic peripheral neuropathy includes optimizing blood sugar control, painkillers and psychological support therapy, but none of them can cure diabetic peripheral neuropathy

Method used

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  • Purpose of modified thymosin beta 4 in respect of treating diabetic peripheral neuropathy
  • Purpose of modified thymosin beta 4 in respect of treating diabetic peripheral neuropathy
  • Purpose of modified thymosin beta 4 in respect of treating diabetic peripheral neuropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] In this example, the effect of the modified recombinant human thymosin β4 on the treatment of diabetic peripheral neuropathy was evaluated by using a mouse diabetic peripheral neuropathy model.

[0031] 1. Materials and methods

[0032] 1.1 Drugs:

[0033] Modified recombinant human thymosin β4 (hereinafter referred to as rhTβ4), provided by Beijing Northland Biotechnology Co., Ltd., the batch number is C-20180101 (its sequence is shown in SEQ ID NO: 1); specification: 100 μg / cartridge . Prepare the required concentration with physiological saline immediately before use.

[0034] The natural structure of human thymosin β4 is chemically synthesized by Shanghai Taishi Biotechnology Co., Ltd. (hereinafter referred to as cTβ4), and it is prepared to the required concentration with normal saline before use.

[0035] 1.2 Instruments:

[0036] ONE-TOUCH easy-to-use blood glucose meter, a product of Johnson & Johnson;

[0037] Neuromatic-2000 electromyography instrument, ...

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Abstract

The invention relates to the field of disease treatment, in particular to a purpose of modified thymosin beta 4 for treating diabetic peripheral neuropathy in examinees (such as people), and a purposeof the thymosin beta 4 for preparing a medicine for treating the peripheral neuropathy in examinees (such as people). The invention further relates to a method for treating the peripheral neuropathy.The method comprises the step of applying the modified thymosin beta 4 to the examinee having the need.

Description

technical field [0001] The present invention relates to the field of disease treatment. Specifically, the present invention relates to the use of modified thymosin β4 for treating diabetic peripheral neuropathy (diabetic peripheral neuropathy, DPN) in a subject (for example, a human being), and for preparing it for use in a subject ( For example, the use of medicines for the treatment of diabetic peripheral neuropathy in humans. The present invention also relates to a method for treating diabetic peripheral neuropathy, comprising the step of administering the modified thymosin β4 to a subject in need thereof. Background technique [0002] Diabetic peripheral neuropathy (DPN) refers to the occurrence of symptoms and / or signs related to peripheral nerve dysfunction in patients with diabetes, in the absence of other causes. Diabetic peripheral neuropathy is a common complication of diabetes, and its clinical manifestations include various types, among which distal symmetric p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/22A61P3/10A61P25/02
Inventor 聂李亚许松山马素永马杉姗汤晓闯
Owner BEIJING NORTHLAND BIOTECH
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