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Applications of NADH and/or NMN in prevention and treatment of male erectile dysfunctions

A technology for erectile dysfunction and men, which is applied in the direction of medical preparations containing active ingredients, diseases, organic active ingredients, etc., and can solve problems such as no research reports on its prevention or treatment of male erectile dysfunction

Inactive Publication Date: 2019-09-17
HOBOOMLIFE BIO TECH SHENZHEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] NADH and NMN have the functions of anti-aging, improving immunity, and treating cardiovascular and cerebrovascular diseases, etc., but there are no research reports on the prevention or treatment of male erectile dysfunction

Method used

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Experimental program
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Effect test

Embodiment 1

[0031] 1.1 Materials and methods

[0032] animal

[0033] Kunming mice, 36-38 g, 50 females and 25 males, were purchased from Shanghai Experimental Animal Center. New Zealand white rabbit, 2.5-3kg, male. The room temperature is 18-22°C, the relative humidity is maintained at 60%-70%, the light is 12hr:12hr (light:dark), and the environment is adapted for 3 days before use.

[0034] Reagent and preparation

[0035] NADH and NMN are prepared by the inventors themselves. Viagra (sildenafil citrate), produced by Pfizer Pharmaceuticals. Estradiol valerate, produced by DELPHARM Lille S.A.S., France, and packaged by Bayer Healthcare Co., Ltd. Guangzhou Branch. Progesterone injection was produced by Zhejiang Xianju Pharmaceutical Co., Ltd. Sodium nitroprusside (sodium nitroferricyanide, SNP) was purchased from Sigma. The cGMP assay kit was purchased from China Institute of Atomic Energy, and the NO assay kit was provided by Nanjing Jiancheng Bioengineering Institute.

[0036] ...

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PUM

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Abstract

The present invention belongs to the field of research and development of medicines and health-care products, and provides new applications of NADH and / or NMN in preparing medicines and / or health-care products for prevention and treatment of male erectile dysfunctions. Administration of the NADH / NMN can activate nitric oxide synthase, thus stimulates a synthesis amount of nitric oxide, and has significant prevention and treatment effects on the male erectile dysfunctions caused by NO synthesis disorder.

Description

technical field [0001] The invention belongs to the field of research and development of medicines and health products, and in particular relates to the application of NADH and / or NMN in the preparation of drugs and / or health products for the prevention and treatment of male erectile dysfunction. Background technique [0002] Nicotinamide-adenine dinucleotide (NADH) and nicotinamide-adenine-mononucleotide (NMN) are physiological substances in the human body, present in all living cells, including human cells. These substances are cofactors for many enzymes, most of which catalyze oxidation-reduction reactions. [0003] Male erectile dysfunction refers to the normal anatomical penis, in the appropriate environment and place and with sufficient sexual stimulation, the penis cannot be erected or the erection hardness and time are not enough to achieve the ability to complete normal sexual intercourse. The etiology of erectile dysfunction includes psychological factors, endocri...

Claims

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Application Information

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IPC IPC(8): A61K31/7084A61K31/7076A61P15/10
CPCA61K31/7076A61K31/7084A61P15/10A61K2300/00
Inventor 陈建生段志刚
Owner HOBOOMLIFE BIO TECH SHENZHEN CO LTD
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