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Blood aripiprazole drug concentration monitoring kit and detection method thereof

An aripiprazole and kit technology, which is applied to the field of aripiprazole therapeutic drug monitoring kits in blood, can solve the problems of high technical requirements for experimenters, inaccurate qualitative and quantitative, complicated preprocessing, etc. The effect of personnel operation error, simple and fast detection process, and reduced experimental cost

Inactive Publication Date: 2019-10-22
苏州艾迪迈医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Previous methods have problems such as complicated pre-treatment, inaccurate qualitative and quantitative results, high cost, long analysis time, or high technical requirements for experimenters.

Method used

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  • Blood aripiprazole drug concentration monitoring kit and detection method thereof
  • Blood aripiprazole drug concentration monitoring kit and detection method thereof
  • Blood aripiprazole drug concentration monitoring kit and detection method thereof

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Embodiment Construction

[0034] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further elaborated below in conjunction with illustrations and specific embodiments.

[0035] 1. Preparation of Aripiprazole Therapeutic Drug Monitoring Kit:

[0036] Standard curve reagent: Aripiprazole is prepared into a series of concentrations with animal serum containing 2% stabilizer and 2% plasticizer, respectively 0.06mg / L, 0.15mg / L, 0.40mg / L, 0.80mg / L , 1.5mg / L, 2.0mg / L, 1.0ml per bottle. The above components were freeze-dried and stored at the bottom of the assay bottle.

[0037] Quality control reagent: Aripiprazole is formulated with animal serum containing 2% stabilizer and 2% plasticizer to three concentrations of high, medium and low, respectively 0.10mg / L, 0.6mg / L, 1.5mg / L, Dispense 1.0ml per bottle. The above components were freeze-dried and stored at the bottom of the assay bottle.

[0038] S...

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Abstract

The invention relates to the field of medical detection and in particular to a blood aripiprazole therapeutic drug monitoring kit developed based on multi-dimensional online solid-phase extraction liquid chromatography analytical technology, more specifically to a method for accurately and quantitatively detecting aripiprazole drug concentration in blood by online solid-phase extraction and multi-dimensional liquid chromatography analytical technology. The kit includes a calibration reagent, a quality control reagent, a processing liquid, an extract liquid, a washing liquid, and an eluent. Thetherapeutic drug monitoring kit of the invention only needs to centrifuge a blood sample, achieves low repeated detection variability, high accuracy and stability, and low detection cost, has variousmethodological indicators that satisfy the requirement for monitoring the blood aripiprazole therapeutic drugs, and is easy to generalize.

Description

technical field [0001] The invention relates to the field of medical detection, in particular to a kit for monitoring aripiprazole therapeutic drug in blood developed based on multidimensional online solid phase extraction liquid chromatography analysis technology, more specifically, it adopts online solid phase extraction and multidimensional liquid A method for accurate and quantitative monitoring of aripiprazole drug concentration in blood by phase chromatography analysis technology. Background technique [0002] Aripiprazole is a new type of atypical antischizophrenia drug, which has a bidirectional regulation effect on the DA nervous system and is a stabilizer of DA transmitters. It has high affinity with D2, D3, 5-HT1A and 5-HT2A receptors. It produces anti-schizophrenia effect through partial agonism on D2 and 5-HT1A receptors and antagonism on 5-HT2A receptors. The effective blood concentration of aripiprazole is 0.15-0.5mg / L, and when the blood concentration>0....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/16G01N30/34G01N30/86
CPCG01N30/06G01N30/16G01N30/34G01N30/8631
Inventor 石功名何伶秀杨凡
Owner 苏州艾迪迈医疗科技有限公司
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