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Equipment and method for inactivating blood component pathogens by riboflavin photochemical method

A technology of blood components and riboflavin light, applied in the direction of irradiation, disinfection, etc., can solve the problems of pathogen transmission risk, white blood cell pollution, etc., and achieve the effect of improving the inactivation effect and reducing the damage

Inactive Publication Date: 2020-01-03
BLOOD TRASFUSION INST CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

[0003] In order to solve the problems existing in the prior art, the present invention provides equipment and methods for inactivating blood component pathogens by using riboflavin photochemical method, which solves the problems of pathogen transmission risk and leukocyte contamination risk faced by blood transfusion at present

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  • Equipment and method for inactivating blood component pathogens by riboflavin photochemical method
  • Equipment and method for inactivating blood component pathogens by riboflavin photochemical method
  • Equipment and method for inactivating blood component pathogens by riboflavin photochemical method

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[0030] The specific embodiments of the present invention are described below so that those skilled in the art can understand the present invention, but it should be clear that the present invention is not limited to the scope of the specific embodiments. For those of ordinary skill in the art, as long as various changes Within the spirit and scope of the present invention defined and determined by the appended claims, these changes are obvious, and all inventions and creations using the concept of the present invention are included in the protection list.

[0031] Such as Figure 5 Shown, a method for riboflavin and ultraviolet light inactivation of pathogens, the main operation steps are that riboflavin solution (concentration is 50 μmol / L) is added in the blood product, then exposed to narrow-band (309nm-313nm) ultraviolet light, Stimulate riboflavin to undergo electron transfer, damage DNA and RNA in blood components, achieve the purpose of inactivating pathogens and lympho...

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Abstract

The invention discloses a method for inactivating blood component pathogens by a riboflavin photochemical method. The method for inactivating blood component pathogens by the riboflavin photochemicalmethod comprises the steps as follows: S1, adding a riboflavin solution with concentration of 50 [mu]mol / L to a blood product to obtain new blood; S2, transferring the blood product under illumination, removing dissolved oxygen in blood components by a nitrogen circulating system, and reducing production of oxygen free radicals; and S3, exposing the obtained new blood under narrow-spectrum ultraviolet light with the wave peak of 309 nm-313 nm, exciting riboflavin to have electron transfer, and damaging DNA and RNA in blood components to achieve the purposes of inactivating pathogens and lymphocytes. Equipment for inactivating blood component pathogens by the riboflavin photochemical method comprises illumination pretreatment equipment, illumination equipment and product storage equipment.The problems of pathogen spreading and leukocyte contamination risks in current blood transfusion are solved.

Description

technical field [0001] The invention relates to the field of riboflavin photochemical method for inactivating blood component pathogens, in particular to equipment and methods for using riboflavin photochemical method to inactivate blood component pathogens. Background technique [0002] With the development of blood pathogen detection technology, the risk of blood transfusion infection has been greatly reduced, but the pathogen detection window period still exists, and the current conventional detection methods cannot cover all known blood-transmitted pathogens. New and re-emerged blood-transmitted pathogens still threaten the safety of blood transfusion. In particular, platelets (PLT) are routinely stored at 20-24°C, and the risk of bacterial contamination is higher. Continuous and stable blood-borne bacterial contamination has become the biggest threat to blood supply institutions. The development of pathogen inactivation technology can effectively reduce the risk of bloo...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/10A61L101/44
CPCA61L2/0076A61L2202/22
Inventor 刘忠尹云弟李玲龚丽
Owner BLOOD TRASFUSION INST CHINESE ACAD OF MEDICAL SCI
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