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A method for stimulating retinal cells and treating vision loss

A retinal cell, retinal technology, applied in chemical instruments and methods, treatment, phototherapy, etc., can solve the problems of low resolution, insufficient to restore functional vision, limit the acceptability of retinal surgeons, etc., to restore vision Effect

Pending Publication Date: 2020-02-07
LAMBDAVISION INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this design has the obvious disadvantage that it requires external hardware such as glasses and surgically implanted external devices
In addition, implants provide insufficient resolution to restore functional vision, and the surgical complexity required for implantation limits adoption by the retinal surgeon community

Method used

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  • A method for stimulating retinal cells and treating vision loss
  • A method for stimulating retinal cells and treating vision loss
  • A method for stimulating retinal cells and treating vision loss

Examples

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Embodiment

[0125] The following examples further describe and demonstrate embodiments within the scope of the present invention. The examples given are for the purpose of illustration only and should not be construed as limitations of the invention, since many variations of the invention are possible without departing from the spirit and scope of the invention.

[0126] ex vivo study design : Evaluation of the protein-based retinal implants of the present invention focused on quantifying the spatial sensitivity of these implants to demonstrate improved resolution compared to competing technologies. These competing technologies, electrode-based retinal prostheses, use artificial means to capture images, convert light energy into electrical signals, and stimulate the remaining neural circuits in the degenerating retina. Several electrode-based retinal implants are in development, most notably by SecondSight, Pixium Vision and Retinaal Implant AG. Despite improvements in electrode array ...

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Abstract

Protein-based subretinal implants offer a new approach to restoring vision for patients blinded by conditions such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). The presentinvention relates to bacteriorhodopsin-based (BR-based) retinal implants that can be implanted in a subretinal position to replace degenerated photoreceptor cells.

Description

[0001] Statement Regarding Federally Funded Research [0002] This invention was made with government support under grants from the National Institutes of Health (GM-34548, 1R41 EY023461-01) and the National Science Foundation (IIP-1448244, IIP-1632465). The government has certain rights in this invention. technical field [0003] Protein-based subretinal implants offer a new way to restore vision to patients who have gone blind due to diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). The present invention relates to bacteriorhodopsin-based (BR-based) retinal implants that can be implanted in subretinal locations to replace degenerated photoreceptor cells. Background technique [0004] The retina is the multilayered tissue that lines the concave inner surface at the back of the eye. Photoreceptor cells in the inner retina are activated by light entering the eye and convert the light signals into electrochemical signals, which are transm...

Claims

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Application Information

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IPC IPC(8): A61F2/14A61F9/00A61L27/22A61N5/06A61K38/16C07K14/215
CPCA61F2/14A61F9/0017A61N5/0603A61N5/0622A61F2009/00863A61N2005/0648A61N2005/0663A61K38/164A61L27/50A61L27/54A61L2300/252A61L2430/16A61L27/227B32B2535/00A61N1/36046B32B7/023B29D11/0073
Inventor R·R·伯奇N·瓦格纳J·A·格雷科
Owner LAMBDAVISION INC
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