Application of a group of metabolic markers in early diagnosis of coronary heart disease events of patients with metabolic syndrome

A technology of metabolic markers and metabolic syndrome, applied in the application field of early diagnosis of coronary heart disease events, can solve the problem of inability to early diagnosis of coronary heart disease events, affecting the detection and early intervention of coronary heart disease events, lack of metabolic syndrome and coronary heart disease omics differences, etc.

Active Publication Date: 2020-02-21
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, due to the lack of omics difference research between metabolic syndrome and coronary heart disease, there are no mature omics markers for the diagnosis of metabolic syndrome and coronary heart disease. Early diagnosis of coronary heart disease events in patients
This deficiency affects the detection and early intervention of coronary heart disease events in patients with metabolic syndrome

Method used

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  • Application of a group of metabolic markers in early diagnosis of coronary heart disease events of patients with metabolic syndrome
  • Application of a group of metabolic markers in early diagnosis of coronary heart disease events of patients with metabolic syndrome
  • Application of a group of metabolic markers in early diagnosis of coronary heart disease events of patients with metabolic syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Diagnostic efficiency of target metabolites in distinguishing patients with metabolic syndrome and patients with coronary heart disease

[0023] 1. Experimental samples, instruments and reagents

[0024] Training set samples: 40 patients with metabolic syndrome and 249 patients with coronary heart disease were collected from the First Affiliated Hospital of Zhengzhou University, who were age- and gender-matched according to strict inclusion and exclusion criteria;

[0025] Validation set samples: 16 patients with metabolic syndrome and 23 patients with coronary heart disease were collected from the Fifth Affiliated Hospital of Zhengzhou University, who were age- and gender-matched according to strict inclusion and exclusion criteria.

[0026] The inclusion criteria for patients with metabolic syndrome and coronary heart disease are as follows:

[0027] Patients with metabolic syndrome: according to the diagnostic criteria recommended by the Diabetes Society ...

Embodiment 2

[0067] Example 2: Early diagnosis kit for coronary heart disease events in patients with metabolic syndrome

[0068] An early diagnostic kit for coronary heart disease events in patients with metabolic syndrome, containing standard diagnostic markers, the diagnostic markers are histidine, phosphatidylcholine PC (16:0 / 16:0), lysophospholipid Acylcholine LysoPC(17:0) and Hypoxanthine.

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Abstract

The invention discloses application of a group of metabolic markers in early diagnosis of coronary heart disease events of patients with metabolic syndrome. Metabolic syndrome is a high risk factor for the coronary heart disease, and patients with metabolic syndrome are at higher risk of the coronary heart disease. Through the application disclosed by the invention, a group of metabolic markers comprising histidine, phosphatidylcholine PC (16:0 / 16:0), lysophosphatidylcholine lysoPC (17:0) and hypoxanthine is discovered and can be used for diagnosing and distinguishing patients suffering from metabolic syndrome and patients suffering from the coronary heart disease, and the metabolic markers further can be used for preparing a kit for early diagnosing the occurrence of the coronary heart disease events of the patients suffering from metabolic syndrome.

Description

technical field [0001] The invention belongs to the field of disease detection and diagnosis, and relates to the discovery and application of disease diagnostic markers, in particular to the application of a group of metabolic markers in the early diagnosis of coronary heart disease events in patients with metabolic syndrome. Background technique [0002] Metabolic syndrome is a syndrome that includes abdominal obesity, insulin resistance, dyslipidemia, and elevated blood pressure. According to the diagnostic criteria recommended by the Diabetes Society of the Chinese Medical Association, metabolic syndrome can be diagnosed with more than 3 of the following 4 items: 1. Overweight or obesity (BMI ≥ 25); 2. Fasting blood glucose (FPG ≥ 6.1mmol / L ) and (or) have been diagnosed with diabetes and treated; 3. Hypertension systolic blood pressure / diastolic blood pressure ≥ 140 / 90mmHg and (or) have been diagnosed with diabetes and treated; 4. Blood lipid disorders fasting triglyce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/92G01N33/96
CPCG01N33/6893G01N33/92G01N33/96G01N2800/324G01N2800/04
Inventor 康建师莹莹荆自伟孙志刘丽伟左莉华杜书章杜秋争张俊
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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