744 results about "CHD - Coronary heart disease" patented technology

The present invention relates to traditional Chinese medicine for treating coronary heart disease and stenocardia is made from (by wt.%) salvia root 50-97%, notoginseng 2-48% and borneol 0.2-3%, in which the salvia root and notoginseng and hot extracted with water, then filtering, concentrating, alcohol precipitating, standing still, recovering ethyl alcohol, concentrating, into extractum, further blended with borneol and adjuvant polyglycol-6000 to form into product.

Methods for assessing the risk of developing Type 2 diabetes and other related disorders include obtaining an NMR derived reference spectrum for a known glucose concentration sample and storing this information as a reference standard. A patient blood sample is collected and NMR derived patient spectrums for the blood sample are obtained. The two NMR data sets (the reference and the patient) are compared and a glucose concentration is determined for the patient sample. The glucose concentration can be evaluated with a blood sample undergoing lipoprotein cholesterol evaluation. The NMR based test can be used to concurrently provide a glucose concentration and lipoprotein constituent values based on a single testing event. The disclosure also includes a multi-purpose test, i.e., a test which concurrently provides lipoprotein screening and coronary heart disease risk evaluation along with a diabetes screening and risk assessment for developing Type 2 diabetes. A method for assessing diabetes includes identifying the presence of diabetic dyslipidemia based on the values of predetermined NMR measured lipoprotein constituents.

The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other preferred embodiments, the GPCR is coupled to Gi and lowers the level of intracellular cAMP. In other preferred embodiments, the GPCR is expressed endogenously by adipocytes. In further preferred embodiments, the GPCR inhibits intracellular lipolysis. In other further preferred embodiments, the GPCR is a nicotinic acid receptor. The present invention also relates to methods of using a modulator of said GPCR. Preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, stroke, insulin resistance, and type 2 diabetes.

In a method to support the diagnosis and / or therapy of a pathological change of a blood vessel of a patient, in particular in the context of coronary heart disease at a first point in time of a pixel-based or voxel-based first image is acquired with the blood vessel of interest by an imaging method, a determination is made from the first image of a quantity of existing non-calcified plaque and a quantity of existing calcium-rich plaque, a determination of a first indicator value is made from the quantities of the different plaque types that represents a measurement of the quantity and the composition of plaque present in the blood vessel at the first point in time, a comparison of the first indicator value is made with at least one limit value stored in a storage of a data processing device, and dependent on the comparison, a presentation is made on an output unit associated with the electronic data processing device of either a proposal for a measure to be undertaken on the patient, or a proposal for no measure.

The invented healthy edible salt is prepared by mixing with sodium chloride, various amino acid, peptide substance, vitamin B family, polysaccharide, or chitin, antioxidant, nucleic acid seasoning, potassium chloride, calcium salt, magnesium salt, selenium salt, and potassium iodide. It can effectively prevent various diseases, also can prevent osteoporosis, cancer, diabetes, dysinsulinosis, lithiasis, coronary heart disease, senile dementia, bark farus etc. it also possesses the functions of antisenility, antifatigue, antidepression, improving immune power, promoting growth etc.

The invention relates to novel compounds as LXR receptor stimulating agents and a medicament composition containing the compounds or pharmaceutically acceptable salt thereof and also relates to a method for preparing the compounds and the medicament composition thereof. The invention discloses application of the compounds as pharmacological active substances, in particular application in treating cardiovascular diseases such as hypertension, hyperlipemia, hypercholesterolemia, atherosclerosis and coronary heart disease, as well as inflammation, adiposis, diabetes, metabolic syndrome and the like.

The invention discloses a health-care noodle with functions of lowering pressure, blood lipid and sugar and softening blood vessel. The health-care noodle comprises the following materials in parts by weight: 60-80 parts of flour, 4-8 parts of gynostemma pentaphyllum, 3-5 parts of gingko leaves, 2-4 parts of polygonum multiflorum, 3-4 parts of haw, 2-3 parts of chrysanthemum, 1-3 parts of medlar, 5-10 parts of black fungus, 5-10 parts of mushroom and 2-6 parts of onion. The product has excellent improvement effects for patients suffering from hypertension, hyperglycemia and hyperlipoidemia, persons with poor sleep and endocrinopathy and in fatigue state for a long time, heart cerebrovascular sufferers and sub-health persons and better preventive treatment effects for arteriosclerosis, hypertension and coronary heart disease and can enhance disease-resistant abilities. The invention increases new noodle variety and ensures that the traditional noodle is more nutritive without any side effect.

The invention relates to an intravascular ultrasound image and intravascular-OCT image fusing method. The method includes the following steps of (a) image retrieval, wherein for intravascular ultrasound (IVUS) images and intravascular (IV)-OCT images collected at the same position on a blood vessel section, a frame of IV-OCT image is taken as a reference image, and an image to be registered is selected from the n frames of IVUS images collected from the point; (b) IVUS image and IV-OCT image registration; (c) IVUS image and IV-OCT image fusion. IV-OCT image data and IVUS image data of the same blood vessel section are fused, the advantage of high tissue penetrating power of IVUS imaging and the advantage of high resolution of IV-OCT imaging are brought into full play, more comprehensive description of blood vessel walls and atherosclerotic plaques is obtained, and a reliable basis is provided for research on the coronary heart disease and the like.

A substantially purified substance having the properties of a bacterial microcin methionine analog, methionine synthesis inhibitor, tRNA-methionine synthase inhibitors or methionine competitive inhibitor capable of inhibiting tumor cell growth without inhibiting the growth of normal cells or treating neoplastic diseases, and may be used alone or in combination with other anti-cancer agents. The purified substance may also have anti-hyperhomocysteineuria and / or anti-infective properties, such as antifungal activity. The purified substance can be safely administered to animals including humans for the treatment of neoplastic, hyperhomocysteinemia and / or infectious diseases for the treatment of those diseases.

The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.

The present invention belongs to an organic compound preparing technology. Beta-hydroxyl-beta-methyl butyric calcium (HMB-Ca) is prepared using 4-methyl-4-hydroxy-2-propione as raw material and wateras solvent and through haloform reaction in water solution of NaOBr, acidification, isobutanol extraction, reaction of HMB acid in isobutanol extract with Ca(OH)2 to produce salt HMB-Ca. The said process has high product purity and less environmental pollution. The product HMB-Ca may be used in promoting the growth of muscles, strengthening immunity, reducing cholesterin and low-density lipoprotein level, preventing coronary heart disease and cardiac vascular disease, strengthening body's nitrogen-fixing capacity and maintaining body's protein level.

This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attached to Carbon 21 or / and 22, or / and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

The invention provides mulberry leaf and tartary buckwheat fine dried noodles. The mulberry leaf and tartary buckwheat fine dried noodles are prepared from 55-70 parts by mass of tartary buckwheat flour, 15-30 parts by mass of wheat gluten, 5-15 parts by mass of high gluten wheat flour, 3-10 parts by mass of mulberry leaf powder, 0.5-1.5 parts by mass of edible salt, 0.3-0.7 part by mass of sodium carbonate, 0.1-0.3 part by mass of konjac gum, 0.1-0.3 part by mass of xanthan gum and 35-42 parts by mass of drinking water. A preparation method of the mulberry leaf and tartary buckwheat fine dried noodles comprises the processes of preparation of a noodle improver solution, dough kneading, ripening, tabletting, drying, packaging and the like. The products are unique in formula, have excellent taste, are rich in nutrients, have prominent health care functions and are suitable for all kinds of people to eat, especially patients with constipation, obesity, diabetes mellitus, hypertension and coronary heart diseases.

The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and / or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.

The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection.

The invention relates to the field of medical biotechnology, in particular to a making method for coronary heart disease and apoplexy risk diagnosis kit. The kit is used for quantitative analysis of Lp-PLA2 level in human plasma or blood serum by enzyme linked immunosorbent assay, so as to prevent heart disease and apoplexy.

A composition is provided which contains policosanol and biotin and which may be used for treating, preventing and or reducing metabolic syndrome, hypercholesterolemia and hypoglycemia related diseases, total cholesterol, LDL-cholesterol, LDL / HDL ratio, triglycerides, coronary heart disease (heart attacks and strokes), inflammation, deep-vein thrombosis, immunoregulatory diseases, cardiovascular diseases, obesity, insulin resistance, dyslipidemia, raised blood pressure, fatigue, premenstrual syndrome, anxiety, depression and / or neurodegenerative disorders, and / or raising HDL cholesterol in humans and animals. The method comprises administering policosanol and biotin which together effectively lower blood glucose levels and lower the LDL / HDL cholesterol ratio. Typically, the administered composition includes about 0.1-10:1 parts by weight of policosanol to biotin.

The invention discloses a PEGylated scutellarin compound and a preparation method thereof. The PEGylated scutellarin compound is as the shown formula (IV) and the PEGylated scutellarin compound can be applied to preparing medicaments applied to treating cerebral thrombosis, cerebral infarction, cerebral apoplexy, sequelaes caused by cerebral apoplexy, coronary heart disease or angina. Compared with the original scutellarin compound, the water solubility of the scutellarin compound is increased obviously; simultaneously, pharmacodynamics experiment on the mice model of cerebral ischemia-reperfusion shows that: compared with the original medicament, the biological activity of the scutellarin promedicament is strengthened obviously.

The invention discloses a metabolic marker combination for evaluating the risks of cardiovascular and cerebrovascular disease of a subject. The metabolic marker combination comprises ceramide Cer d18:1 / 16:0, ceramide Cer d18:1 / 18:0, ceramide Cer d18:1 / 24:0, phenylacetyl glutamine, trimethylamine, glycine betaine and choline. The cardiovascular and cerebrovascular diseases are selected from coronary heart disease, atherosclerosis, atrial fibrillation and heart failure. The metabolic marker combination disclosed by the invention has the advantages of high sensitivity, good specificity, quantification, high detection flux and the like in the aspect of evaluating or predicting the risks of cardiovascular and cerebrovascular diseases.

The invention relates to a method for determining fingerprint spectrum of traditional Chinese medicine for treating coronary heart disease. The method comprises the following steps: preparing a test solution, preparing a reference solution, and carrying out gradient elution under the chromatographic conditions that an Agilent ZORBAX Extend C18 chromatographic column is used as a filling agent, a mobile phase A is methanol and a mobile phase B is 0.4% phosphoric acid water solution; determining under conditions that the flow velocity is at 1.0ml / min, the column temperature is at 35 DEG C and the detection wavelength is 230-240nm, thus obtaining the fingerprint spectrum of traditional Chinese medicine. The method has the characteristics of being simple and convenient, good in reproducibility, more in characteristic peaks, accurate and reliable, and the like, and the quality of the traditional Chinese medicine preparation can be controlled effectively by the established fingerprint spectrum.

The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.

The invention relates to a molecular probe in a medical imaging diagnostic reagent, and in particular relates to a preparation method of an MRI / PET bimodal molecular imaging probe for an atherosclerotic vulnerable plaque. According to the probe, molecular imaging can be performed on a new vessel of the atherosclerotic vulnerable plaque, and early warning of an unstable plaque is realized so as to provide a favorable new molecular imaging technology for early diagnosis and prevention of the coronary heart disease and reduction of serious cardiovascular event risk. The preparation method comprises the following step: chemically synthesizing a new vessel specific MRI / PET bimodal molecular imaging probe 68Ga-GEBP11-DMSA (dimercaptosuccinic acid)-MNPs through condensation reaction and chelating reaction by taking GEBP11 short peptide as a targeting tool and DMSA modified magnetic Fe3O4 nanoparticles (DMSA-MNPs) as carriers.

The invention provides a method of preparing a quick-acting jiuxin orally disintegrating tablet through 3D printing. The disintegrating tablet is formed by spraying a bonder through a nozzle of a 3D printer to bond medicinal powder, the medicinal powder comprises, by mass, 76-85% of, 12-18% of and 2-6% of, and 3D printing parameters include spraying radius of 2.5-10mm, spraying layer height of 0.1-0.5mm and spraying layer number of 10-50 layers. Heating is not needed in the preparation process, so that loss of active ingredients, such as borneol, which are unstable when being heated in conventional preparation methods is avoided; the disintegrating tablet prepared is high in medicine release speed, content of active ingredients meets requirements of the Chinese Pharmacopoeia, and the disintegrating tablet is especially suitable for acute diseases such as coronary heart disease and angina.

The invention relates to health-care rice vinegar and a preparation process thereof. The invention belongs to the technical field of processing of condiments and particularly relates to health-care rice vinegar prepared from millet serving as a main raw material and traditional Chinese medicinal materials. The health-care rice vinegar is prepared from the main raw material comprising millet, traditional Chinese medicinal materials comprising hawthorn, dark plum fruit, semen cassia, lotus leaf, oriental wormwood, oolong, lucid ganoderma, immature bitter orange, aloe, peach kernel, ginger and yam, and auxiliary materials comprising wheat koji, bran, cavings and salt. The health-care rice vinegar has the advantages of 1, comprehensively adjusting lipid metabolism, obviously reducing hyperlipaemia, reducing serum total cholesterol, triglyceride and low-density lipoprotein, obviously increasing high-density lipoprotein and degrading atherosclerotic plaques; 2, reducing blood viscosity, obviously inhibiting platelet abnormal coagulation, improving hemodynamic indexes, promoting blood circulation, avoiding thrombus and effectively preventing apoplexia; and 3, dredging blood vessels, improving blood supply microcirculation, improving brain and heart blood supply insufficiency, inhibiting atherosclerosis and effectively preventing coronary heart disease.

The invention discloses a next generation sequencing based coronary heart disease genetic risk evaluation method. Particularly, the invention relates to screening of coronary heart disease genetic risk loci and establishment of a coronary heart disease genetic risk evaluation model based on the risk loci. Depending on the model, an individual genome is subjected to targeted sequencing to finally obtain coronary heart disease genetic risk of an individual.

The invention discloses an automatic tissue calibration method for an IVUS gray-scale image. According to the technical scheme, the automatic tissue calibration method includes the steps of firstly, extracting textural features of the IVUS gray-scale image; secondly, carrying out dimension reduction processing on the extracted textural features; finally, calibrating textural feature data through an Adaboost classifier, and accordingly completing automatic identification and automatic calibration of different-ingredient plaque tissues. By means of the automatic tissue calibration method, original radio frequency signals and backscattering signals of an imaging device do not need to be collected, the calibration process is not limited by an IVUS imaging system and can be completed in a full-automatic mode, identification and calibration results which are objective, accurate and high in repeatability can be obtained, and the bases can be provided for computer-aided diagnosis of the coronary heart disease, making of an interventional treatment plan and the like.

The present invention relates to a medicine in treating coronary heart disease or coronary heart disease with complication of cardiac functional insufficiency. It is characterized by that it made rhodiola kirilowii and notoginseng as raw material, red peony root and ginkgo leaf also can also be added. Said invention also discloses its preparation method.

The invention relates to an extract of preventing and treating coronary heart disease and stenocardia and a preparation method and application thereof. The preparation method comprises the following steps of: 1, extracting medicinal materials such as red-rooted salvia root and pseudo-ginseng to obtain an extraction solution; 2, separating the extraction solution by using macroporous resin to obtain an extract; and 3, taking the extract and borneol together serving as medicinal active ingredients to prepare a medicinal preparation.

This invention provides a process for extracting the flavonoid and alkaloid components from lotus leaf and provides a method for the reduction of body weight, total cholesterol (TC), low density lipoprotein (LDL) cholesterol, and triglycerides (TG). It also provides a method for increasing high density lipoprotein (HDL) cholesterol and the prevention of coronary heart disease (CHD). There are 10% to 80% flavones and 10% to 80% alkaloids in the lotus leaf extract powder of this invention. This process produces an improved standardized raw material that may be utilized as a single dietary supplement, food additive, or medicine and it may be added to other plant extracts, nutraceuticals, or pharmaceuticals.