Drug for treating coronary heart disease or coronary disease and cardiac insufficiency, and its preparation method

A technology for cardiac insufficiency and coronary heart disease, which can be used in pharmaceutical formulations, drug combinations, cardiovascular system diseases, etc.

Inactive Publication Date: 2004-08-25
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the commonly used medicine for the treatment of coronary heart disease is to take nitroglycerin tablets. Nitroglycerin has a significant expansion effect on cerebral blood vessels. Immediately after taking the medicine, flushing and headache appear, and "orthostatic hypotension" occurs when standing, which is prone to errors. Jue, elderly patients or patients taking the medicine for the first time may feel dizzy and headache after taking the medicine while sitting. Taking nitroglycerin tablets for a long time will produce certain side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1. A medicine for treating coronary heart disease or coronary heart disease combined with cardiac insufficiency, which is a medicament made from Rhodiola rosea and Panax notoginseng as raw materials, wherein the weight ratio of raw materials is:

[0041] Rhodiola 200kg Panax notoginseng 200kg

[0042] Add water and decoct it by conventional method, extract the active ingredients therein, add conventional medical auxiliary materials, and make oral liquid.

Embodiment 2

[0043] Example 2. A medicine for treating coronary heart disease or coronary heart disease combined with cardiac insufficiency, wherein the weight ratio of each raw material is,

[0044] Rhodiola 400kg Panax notoginseng 200kg

[0045] Its preparation method is as follows,

[0046] (1) Get Rhodiola rosea, add 6 times the amount of 50% ethanol to soak and extract at 60°C, filter, recover ethanol under reduced pressure, concentrate, add water to dilute, let stand, filter, and the filtrate is adsorbed by macroporous adsorption resin, Rinse with distilled water until the effluent is colorless, elute with dilute ethanol, collect the eluate, recover ethanol, concentrate under reduced pressure, and obtain the rhodiola rosea extract;

[0047] (2) Get Radix Notoginseng, carry out percolation according to percolation method, use 90% ethanol as solvent, after soaking for 30 hours, carry out percolation with a speed of 2ml per minute, collect percolation liquid until the total saponins o...

Embodiment 3

[0049] Example 3. A medicine for treating coronary heart disease or coronary heart disease combined with cardiac insufficiency, wherein the weight ratio of each raw material is,

[0050] Rhodiola 200kg Panax notoginseng 300kg

[0051] Its preparation method is as follows,

[0052] (1) Take Rhodiola rosea, crush it into a coarse powder, add 10 times the amount of water to decoct twice for 2 hours each time, filter, combine the filtrate, and recover under reduced pressure at 70°C and -0.5MPa to contain 3g of crude drug / ml, add ethanol to 60% alcohol content, stand still for 20 hours, filter, recover ethanol under reduced pressure at 70°C and -0.5MPa until there is no alcohol smell, continue to concentrate to contain 4g crude drug / ml, add ethanol to contain alcohol 70%, add 15% NaOH to adjust the pH to 7, stand still for 20 hours, filter, recover ethanol, concentrate under reduced pressure to obtain the rhodiola rosea extract;

[0053] (2) Get Radix Notoginseng, carry out per...

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PUM

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Abstract

The present invention relates to a medicine in treating coronary heart disease or coronary heart disease with complication of cardiac functional insufficiency. It is characterized by that it made rhodiola kirilowii and notoginseng as raw material, red peony root and ginkgo leaf also can also be added. Said invention also discloses its preparation method.

Description

technical field [0001] The invention relates to a Chinese herbal medicine combination medicine for treating coronary heart disease or coronary heart disease combined with cardiac insufficiency and a preparation method thereof. Background technique [0002] Coronary heart disease is the abbreviation of coronary heart disease, which is a kind of coronary circulation disorder due to fixed (atherosclerosis) or dynamic (vasospasm) stenosis or obstruction of coronary arteries, which causes imbalance between myocardial oxygen supply and demand. A heart disease that causes myocardial ischemia, hypoxia or necrosis, also known as ischemic heart disease. The basic lesion of the disease is the blood vessel that supplies nutrients to the myocardium—atherosclerosis has occurred in the coronary arteries, and the main manifestations are angina pectoris, arrhythmia, heart failure, and possible sudden death. In recent decades, the incidence of coronary atherosclerotic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P9/10
Inventor 肖伟戴翔翎凌娅王振中尚强
Owner JIANGSU KANION PHARMA CO LTD
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