Method of preparing quick-acting jiuxin orally disintegrating tablet through 3D printing

Abstract

The invention provides a method of preparing a quick-acting jiuxin orally disintegrating tablet through 3D printing. The disintegrating tablet is formed by spraying a bonder through a nozzle of a 3D printer to bond medicinal powder, the medicinal powder comprises, by mass, 76-85% of, 12-18% of and 2-6% of, and 3D printing parameters include spraying radius of 2.5-10mm, spraying layer height of 0.1-0.5mm and spraying layer number of 10-50 layers. Heating is not needed in the preparation process, so that loss of active ingredients, such as borneol, which are unstable when being heated in conventional preparation methods is avoided; the disintegrating tablet prepared is high in medicine release speed, content of active ingredients meets requirements of the Chinese Pharmacopoeia, and the disintegrating tablet is especially suitable for acute diseases such as coronary heart disease and angina.

Description

technical field [0001] The invention belongs to the technical field of drug design, and more specifically relates to a method for preparing Suxiao Jiuxin orally disintegrating tablets by 3D printing. Background technique [0002] The core idea of ​​3D printing (threedimensionprinting, 3DP) first originated in the United States at the end of the 19th century, but it did not take shape until the mid-1980s. In 1986, American Charles Hull invented the first 3D printer. my country began to study 3D printing technology in the 1990s, and these processes began to develop from laboratory research to engineering and productization around 2000. The book "3D Printing: From Imagination to Reality" written by Hod Lipson and others regards 3D printing manufacturing technology as an important symbol of the third industrial revolution, and points out that although it still needs to be perfected, 3D The printing technology market has huge potential. In the stage of continuous evolution from ...

AI Technical Summary

Problems solved by technology

This type of method is simple and easy to implement, and the cost is low, but the stability of the volatile drug is poor, the dosage is not accurate, and it cannot be stored for a long time

At present, inclusion technology and microencapsulation technology are also used to improve the stability of volatile oil, but the inclusion technology has many steps, and the retention rate of volatile oil in microencapsulation technology is too low

[0006] Suxiao Jiuxin Pill, which has been included in the 2015 edition of "Chinese Pharmacopoeia", is composed of two traditional Chinese medicines, Chuanxiong and Borneol. It is a brown-yellow dropping pill, each pill weighs 40mg, and normally takes 4-6 pills at a time. 10-15 pills, and its onset time is longer, and it can be completely dissolved within 10 minutes, which cannot meet the requirements for the treatment of acute attack diseases