Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof

a statin response and gene polymorphism technology, applied in the field of statin response and disease risk, can solve the problems of reducing the circulating ldl, a major risk factor, and de-prioritizing or delayed use of the drug in these individuals, so as to reduce the risk of cvd or chd, and increase the risk
US20140235605A1Inactive Publication Date: 2014-08-21CELERA CORPORATION
0 Cites 19 Cited by

Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
CELERA CORPORATION
Publication Date
2014-08-21
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection.
Need to check novelty before this filing date? Find Prior Art

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation application of U.S. non-provisional application Ser. No. 13 / 085,955, dated Apr. 13, 2011, which claims the benefit of U.S. provisional application Ser. No. 61 / 325,689 filed Apr. 19, 2010, U.S. provisional application Ser. No. 61 / 332,509 filed May 7, 2010, and U.S. provisional application Ser. No. 61 / 405,972 filed Oct. 22, 2010, the contents of each of which are hereby incorporated by reference in their entirety into this application.FIELD OF THE INVENTION

[0002] The present invention is in the field of drug response and disease risk, particularly genetic polymorphisms that are associated with response to statins, especially for the prevention or treatment of cardiovascular diseases (CVD) such as coronary heart disease (CHD) (which includes coronary events such as myocardial infarction (MI)) and cerebrovascular events (such as stroke). In particular, the present invention relates to specific single nucleoti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More