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92results about How to "Strong tissue penetration" patented technology

Neutralizing monoclonal antibodies to respiratory syncytial virus

The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratory Syncytial Virus. The invention provides such antibodies, fragments of such antibodies retaining RSV-binding ability, chimeric antibodies retaining RSV-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Finally, the invention provides for diagnostic and therapeutic methods employing the antibodies and nucleic acids of the invention.
Owner:INTRACEL RESOURCES

Methods for using resonant acoustic and/or resonant acousto-EM energy to detect and/or effect structures

The present invention makes use of resonant acoustic and / or acousto-EM energy applied to inorganic or biologic structures for the detection and / or identification, and for augmentation and / or disruption of function within the biologic structure. In particular, the invention provides a method of generating resonant acoustic and / or acousto-EM energy in biologic structures such as virus, bacteria, fungi, worms and tumors for the detection and disruption of these structures. Moreover, the invention provides a method of augmenting functions of biologic structures such as bone through the generation of resonant acoustic and / or acousto-EM energy in the structure. Systems are also provided for the generation and detection of resonant acoustic and / or resonant acousto-EM energy.
Owner:GR INTELLECTUAL RESERVE LLC

Photosensitive liposome with encapsulated water-soluble medicament

The invention provides a photosensitive liposome with encapsulated water-soluble medicament, which is composed of temperature-sensitive phospholipid, cholesterol and long circulation material and hollow gold nanoparticle, wherein, the hollow gold nanoparticle has a characteristic absorption peak at the near infrared zone with the wavelength of 700-900 nm, and the particle size distribution of the hollow gold nanoparticle is in the range of 20-100 nm. According to the invention, a brand new photosensitive liposome is composed by wrapping water-soluble medicament and hollow gold nanoparticle with temperature-sensitive liposome. Under the extraneous near infrared light, the wrapped hollow gold nanoparticle generates a photo-thermal treatment effect, simultaneously, the photo-thermal effect controls a rapid site-specific delivery of medicament in a large amount from the photosensitive liposome, thereby blood vessels in the tumour part can be damaged or the tumor cells can be killed effectively with a chemical treatment effect of the medicamen. The drug loaded liposome of the present invention realizes synchronous photo-thermal and medicament molecule treatment effect, and the treatment effect of disease such as tumour is substantially improved, and the invention has clinic applicability and real treatment meaning.
Owner:ZHEJIANG UNIV

Neutralizing monoclonal antibodies to respiratory syncytial virus

The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratory Syncytial Virus. The invention provides such antibodies, fragments of such antibodies retaining RSV-binding ability, chimeric antibodies retaining RSV-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Finally, the invention provides for diagnostic and therapeutic methods employing the antibodies and nucleic acids of the invention.
Owner:PILKINGTON GLENN R +4

Bilateral biotin-phthalocyanine zinc conjugate as well as preparation and application thereof

The invention discloses a bilateral biotin-phthalocyanine zinc conjugate as well as preparation and application thereof. According to the conjugate disclosed by the invention, a biotin-cell growth-promoting factor (which is a critical micronutrient for cells to maintain normal functions, growth and reproduction) is used as a tumor target and is covalently connected onto a phthalocyanine zinc photosensitizer capable of being used for a photodynamic therapy, thus obtaining a third-generation anti-cancer photosensitizer for targeted therapy. Meanwhile, according to the conjugate, the biotin instead of a phthalocyanine zinc derivative acts a research object, human breast cancer cell MCF-7 and human embryo lung inoblast HELF act as subject cell lines respectively, a research regarding the in-vitro anti-cancer activity of the biotin is developed, and a prodrug suitable for a molecular targeted therapy is screened out, and a foundation is laid for applying the biotin instead of the phthalocyanine zinc derivative to the targeted therapy of cancers. The compound, namely the conjugate disclosed by the invention, is relatively simple in synthesis method, easily available in raw materials, low in cost, fewer in side reactions, relatively high in yield, easy to purify and beneficial for industrial production.
Owner:FUZHOU UNIV

Imaging drug <68>Ga-NOTA-IF7 targeting Anxa1 in tumor blood vessels and preparation method thereof

The invention belongs to the fields of radiopharmaceuticals and nuclear medicine and provides an imaging drug <68>Ga-NOTA-IF7 targeting Anxa1 in tumor blood vessels and a preparation method thereof. The drug <68>Ga-NOTA-IF7 is used for differential diagnosis and periodization of tumors, accurate positioning of focuses and curative effect monitoring. According to the invention, the tumor imaging drug <68>Ga-NOTA-IF7 is prepared through leaching of <68>Ga and <68>Ga-NOTA-IF7 labeling. The preparation method has the advantages of simple preparation technology, convenient operation, small consumption of time, a high labeling rate and a stable marker and facilitates further application of the drug in clinical practice, scientific research and medicinal development. The invention also provides a novel positive electron tumor imaging agent. The novel positive electron tumor imaging agent has good targeting to tumors, so tumor imaging effects are improved, and a visual tool is provided for differential diagnosis and periodization of tumors, accurate positioning of focuses and curative effect monitoring. <68>Ga-NOTA-IF7 is a labeled compound belonging to polypeptide and has the advantages of small molecular weight, low immunogenicity, good tissue penetrability, high tumor tissue affinity and good application prospects.
Owner:JIANGSU INST OF NUCLEAR MEDICINE

Fluorescent cobalamins and uses thereof

InactiveUS6905884B2Rapid transportQuick storageBiocideSurgeryCancer cellFluorescence
The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used to as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues, including identifying lymph nodes containing cancer cells, and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.
Owner:UNIV OF UTAH RES FOUND

Nano antibody and preparation method thereof

The invention provides a nano antibody. As for the nano antibody, (1) an amino acid sequence shown in SEQ ID NO:1 is achieved; or (2) compared with the (1), the at least 70% identity, the at least 75%identity, the at least 80% identity, the at least 85% identity, the at least 90% identity, the at least 95% identity, and the at least 99% identity are achieved. According to the embodiments, the nano antibody is an antibody specifically targeting an ion channel TRPV3, the native conformation TRPV3 can be combined, and the nano antibody has the high water solubility, high tolerance, high stability, high antigen bondability, low immunogenicity, high tissue penetrating power, and high expressivity.
Owner:SHENZHEN HUADA GENE INST

Anti-human MSLN (mesothelin) monoclonal antibody

The invention discloses an anti-human MSLN (mesothelin) monoclonal antibody, which is a specific high-affinity nano antibody developed by taking human MSLN as a target and based on a phage display technology. Compared with the prior art, the invention allows the anti-human MSLN monoclonal antibody to be successfully prepared, which is good in specificity, high in affinity and capable of binding tohuman MSLN expressed on the cell surface, and the anti-human MSLN monoclonal antibody is a potential drug for tumor immunotherapy.
Owner:ZHEJIANG BLUE SHIELD PHARM CO LTD

Metal phthalocyanine and application thereof in fields of photothermal materials and photothermal therapy

The invention discloses a metal phthalocyanine and application thereof in the fields of photothermal materials and photothermal therapy. Irradiated by near-infrared laser, a solution containing the metal phthalocyanine disclosed by the invention has a remarkable photothermic effect, capable of implementing photothermal therapy, and the metal phthalocyanine can be used as a photothermal material orto prepare medicines with the effect of photothermal therapy, and is of great significance for the development of multifunctional phototherapeutic medicines.
Owner:FUZHOU UNIV

Human source anti- tetanus exotoxin antibody and preparation method and use thereof

The invention discloses a human source anti-tetanus exotoxin antibody (HTAT-Fab) and preparation method, comprising: constructing human immunity phage antibody bank, screening phage positive clone, further getting HTAT-Fab gene with a specific neutralization activity and high affinity. The gene can be expressed in the procaryotic cell such as E.coli, eukaryotic cell such as microzyme, or mammalian cell such as CHO, purifying to get highly purified HTAT-Fab with a strong tissue penetrability, a high affinity. The HTAT-Fab product can not only eliminate the allergic reaction generated by horse serum anti-tatanus antitoxin (TAT) (foreign protein), but also avoid the blood source for producing human tetanus immunoglobulin (HTIG) and the latent virus pollution.
Owner:北京明新高科技发展有限公司 +2

Synthesis and fluorescence detection imaging application of phosphorescence iridium complex

The invention discloses a preparation method and fluorescence detection application of a phosphorescence iridium complex. The phosphorescence complex has a chemical formula [Ir(CHO-btiq)2(bpy)][PF6]. The invention provides the preparation method of the phosphorescence iridium complex, and the application of the phosphorescence iridium complex to the detection of cysteine and homocysteine. The emission spectrum of the phosphorescent iridium complex is in the near-infrared region; biological imaging of the phosphorescent iridium complex has the advantages of little damage small, strong penetrability and little background spontaneous fluorescence; and the phosphorescent iridium complex has good application prospect in small animal in vivo fluorescence imaging. The iridium complex provided by the invention can realize high selectivity detection of cysteine and homocysteine, and provides the possibility for the construction of a simple and high-selectivity fluorescence chemical sensor for determination of cysteine and homocysteine.
Owner:GANNAN NORMAL UNIV

Polydopamine-coated Prussian blue and silver-loaded nano-composite material, and preparation method and application thereof

The invention discloses a polydopamine-coated Prussian blue and silver-loaded nano-composite material, and a preparation method and an application thereof. The composite material is formed by coatingPrussian blue with polydopamine and then growing nano-silver on the polydopamine in situ, and the particle size of the composite material is 100-150 nm. The preparation method comprises the followingsteps: reacting potassium ferricyanide with polyvinylpyrrolidone to obtain Prussian blue, adding dopamine into a Tris-HCl solution of Prussian blue to prepare polydopamine-coated Prussian blue, and mixing and stirring the obtained polydopamine-coated Prussian blue dispersion, ammonia water, a reducing agent and a silver nitrate solution to react in order to make nano-silver grows on the coating layer polydopamine in situ in order to obtain the product. The nano-composite material has a good antibacterial effect, is not prone to causing drug resistance of bacteria, has good stability and dispersity, the preparation method has the advantages is simple and mild, short in time consumption, low in energy consumption and easy to realize large-scale production, and the nano-composite material canbe used for preparing photo-thermal antibacterial drugs or chronic traumatic infection treatment drugs.
Owner:HUNAN UNIV

Small molecular weight TNF receptor multimeric molecule

The present invention relates to a receptor molecule which binds to TNF comprising all or a functional portion of the extracellular domain (ECD) of two or more TNF-Rs linked via one or more polypeptide linkers. The receptor can further comprise a signal peptide of a secreted protein, such as the signal peptide of the extracellular domain of the TNF-R or the signal peptide of a cytokine. The invention also relates to isolated DNA encoding a receptor molecule which binds to TNF, comprising two or more sequences encoding all or a functional portion of the ECD of TNF-Rs linked via one or more sequences encoding a polypeptide linker. The invention further relates to a method of making a construct which expresses all or a functional portion of the ECD of two or more TNF-Rs linked via one or more polypeptide linkers and cells which express the construct. The invention also relates to a method of inhibiting the biological activity of TNF in a host comprising administering to the host an effective amount of a receptor molecule of the present invention. The invention further relates to receptor molecules which bind cytokines that bind to receptor molecules comprising more than one subunit.
Owner:THE KENNEDY INST OF RHEUMATOLOGY HAMMERSMITH

Er3+/ Yb3+ co-doping calcium fluoraluminate green up-conversion luminescent material and preparation method thereof

The invention belongs to the technical field of inorganic luminescent materials, and particularly relates to an Er3+ / Yb3+ co-doping calcium fluoraluminate green up-conversion luminescent material triggered by near-infrared light and a preparation method thereof. The method adopts a high temperature solid phase method to prepare the Er3+ / Yb3+ co-doping calcium fluoraluminate, high-purity raw materials of Er2O3, Yb2O3, Al2O3, CaF2 and CaCO3 are evenly mixed in proportion, sintering is carried out to obtain the Er3+ / Yb3+ co-doping calcium fluoraluminate luminescent material. The luminescent material emits green light located at about 550 nanometers under the stimulation of 980-nanometer near-infrared light, and the up-conversion luminescent efficiency is higher; the luminescent material has better stability, is environmentally-friendly, has low cost, and can be widely applied to the fields of three-dimensional volumetric display, biomolecule fluorescent labeling probe, optical fiber amplifier and the like; the preparation method is easy in operation and industrial production, and the production cost is low.
Owner:CHANGCHUN UNIV OF SCI & TECH

Anti-CEACAM5 nanometer antibody

The invention provides a nanometer antibody. The antibody comprises: (1) an amino acid sequence shown as SEQ ID NO: 1 or 2 or 3 or 4 or 5 or 6; and (2) the sequences have high sequence homology, suchas more than 80% of sequence homology. According to the embodiment of the invention, nucleic acid specifically encodes the nanometer antibody, and the nanometer antibody can specifically target CEACAM5 and has high water solubility, high tolerance, high stability, high antigen binding property, low immunogenicity and relatively strong tissue penetrating power.
Owner:THE FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIV

Nano antibody for resisting toxoplasma gondii SAG1 as well as coding gene and application thereof

The invention discloses a nano antibody for resisting toxoplasma gondii SAG1 as well as a coding gene and application thereof. A VHH chain amino acid sequence of the nano antibody is as shown by SEQ ID NO. 4. The nano antibody comprises two VHH chains. The nano antibody for resisting the toxoplasma gondii SAG1 is obtained by immunizing a camel by virtue of toxoplasma gondii SAG1 antigen, obtainingan anti-SAG1 nano antibody library, and selecting a nano antibody with good performance from the nano antibody library. The nano antibody has high solubility and conformation stability and high antigen affinity and excellent tissue penetration capability, and has high affinity with SAG1 antigen, the affinity constant KD value is 1.66nM, the toxoplasma gondii can be efficiently detected, and the nano antibody can be used for preparing toxoplasma gondii detection kit.
Owner:ZHEJIANG ACAD OF MEDICAL SCI

Virus-like hollow manganese oxide loaded near-infrared two-b region excited rare earth nanocrystal as well as preparation method and application thereof

The invention discloses a virus-like hollow oxide loaded near-infrared two-b region excited rare earth nanocrystal and a preparation method and application thereof. According to the nanocrystal and the preparation method, an Er and Ho doped NaErF4:2%Ho@NaYF4 rare earth nanomaterial is synthesized through a hydrothermal method, then the nanomaterial is modified on a surface of a virus-like hollow manganese oxide poured into IR1064 through an amidation reaction, and a fluorescent composite probe which is good in biocompatibility and responds to a tumor microenvironment is obtained. According to the fluorescent composite probe, after the manganese oxide is degraded at a tumor, manganese ions are used for chemodynamic therapy and nuclear magnetic resonance imaging contrast agents of metastasis, released rare earth nanocrystals have excitation of 1530 nm and emitted lights of 650 nm and 1180 nm, the light of 1180 nm can be used for tumor imaging navigation surgical resection with no background interference and high resolution and tissue penetrating power in a near-infrared second region, and the light of 650 nm can used for near-infrared first region fluorescence imaging.
Owner:MENGCHAO HEPATOBILIARY HOSPITAL OF FUJIAN MEDICAL UNIV

Anti-human MSLN monoclonal antibody and application thereof

The invention discloses an anti-human MSLN monoclonal antibody and an application thereof, and is a specific and high-affinity single-chain antibody developed by taking human MSLN as a target based ona phage display technology. Compared with the prior art, the anti-human MSLN monoclonal antibody is successfully prepared, the antibody is good in specificity and high in affinity and can be combinedwith human MSLN expressed on the surface of a cell, and the anti-human MSLN monoclonal antibody is a potential drug for tumor treatment.
Owner:NANJING BLUE SHIELD BIOTECH CO LTD

Double-targeted-mediated chemotherapy-photothermal combined cancer therapy compound system, preparation method and application of compound system

The invention discloses a folic acid recognition and pillararene nano-valve controlled-release double-targeted-mediated chemotherapy-photothermal combined cancer therapy compound system, a preparationmethod and application of the compound system, and belongs to the technical field of compound medical materials. The preparation method includes that polypyrrole nanoparticles (PPy NPs) are used as anuclear matrix, a metal organic frame material (MOFs) reaction mother solution directly reacts with the nuclear matrix by means of in-situ growth to form a PPy-MOFs compound nanomaterial, and 'connecting shaft' molecules are modified on the PPy-MOFs compound nanomaterial by means of post-modification for subsequent mounting of a pillararene nano-valve mediated by subject-object acting force; polyethyleneimine polymer (PEI-Fa) modified by folic acid is post-modified on a compound material equipped with a supermolecule nano-valve. Design of the whole compound material therapy system brings synergism of all parts into full play, organic combination of chemotherapy and photothermal therapy is realized, and targeted and controlled drug release is realized through controllability of the nano-valve and folic acid recognition.
Owner:JILIN UNIV

Anti-toxoplasma gondii TRX (Thioredoxin) nano-antibody, encoding gene and application thereof

The invention discloses an anti-toxoplasma gondii TRX (Thioredoxin) nano-antibody, an encoding gene and the application thereof. VHH chain amino acid sequence of the antibody is as shown in SEQ ID No.4. The nano-antibody comprises two VHH chains. The anti-toxoplasma gondii TRX nano-antibody is obtained by immunizing a camel by a toxoplasma gondii TRX antigen to obtain an anti-TRX nano-antibody library, and then screening to obtain the anti-toxoplasma gondii TRX nano-antibody with good performance from the nano-antibody library. The anti-toxoplasma gondii TRX nano-antibody has high water solubility and conformational stability, strong antigen affinity, excellent tissue penetrating capacity, can detect toxoplasma gondii highly effectively, and can be used for preparing a toxoplasma gondii detection kit.
Owner:ZHEJIANG ACAD OF MEDICAL SCI

Nano-antibody of carbofuran pesticide and preparation method and application of nano-antibody

The invention discloses a nano-antibody of carbofuran pesticide and a preparation method and application of the nano-antibody. An amino acid sequence of the nano-antibody is shown as SEQ ID NO.1, genes of the nano-antibody are encoded, and a nucleotide sequence of nano-antibody is shown as SEQ ID NO.2. The nano-antibody is against the carbofuran pesticide and can be used for detecting the carbofuran pesticide, the detection result is accurate, the effect is good, the stability is good, and the detection effect is good under conditions of high temperature and an organic solvent. The nano-antibody can be widely used for the detection of carbofuran pesticide residues in agricultural products and can be taken as a precursor, modifying can be carried out by random or site-specific mutagenesis techniques to obtain mutants with better properties (affinity, specificity, stability and the like), the nano-antibody can be used for developing and further used in fields of food, medicine, agriculture and the like, and the application and promotion value is great.
Owner:SOUTH CHINA AGRI UNIV

Compound, preparation method of compound as well as fluorescent probe containing compound and application

The invention discloses a compound I. The compound I has a structure shown in a formula I (the formula I is shown in the description), wherein R1 is an acyl group, phenyl group or alkyl oxycarbonyl group containing 2-5 carbon atoms; R2 is a halogen atom or hydrogen atom; R3 is an alkyl group containing 1-18 carbon atoms. The invention also discloses a synthesizing method of the compound I, a fluorescent probe containing the compound I and application. The fluorescent probe provided by the invention has the advantages that the selectivity is excellent, the reaction is rapid, and fibroblast activating protein alpha can be simply, rapidly and visually detected.
Owner:NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI

Water-soluble anti-cancer photosensitizer and preparation and application thereof

The invention discloses a water-soluble anticancer photosensitizer and preparation and application thereof. Firstly, mother nucleus of monocarboxyl substituted fluoroboron dipyrrol is prepared from the raw materials of carboxybenzaldehyde, 2,4-dimethyl pyrrole and the like; secondly, two heavy atomic iodines are introduced to the 2th and 6th sites to increase the oxygen quantum yield in triplet and singlet states; thirdly, the compound is further subjected to a condensation reaction with carboxybenzaldehyde, the conjugated system is expanded, the compound is absorbed and moved to a red region,and two carboxyl groups are simultaneously introduced to obtain a water-soluble fluoroboron dipyrrol anti-cancer photosensitizer. The synthetic method of this compound is simple, the raw material iseasy to obtain, the cost is low, the side reactions are few, the yield is high, the purification is easy, and the compound is conducive to industrial production.
Owner:FUZHOU UNIVERSITY

Paraquat hapten, complete antigen, nano-antibody, detection test paper, kit, preparation method and application of paraquat hapten, preparation method of nano-antibody

The invention discloses a paraquat hapten. The paraquat hapten has a structure represented by formula (I) shown in the description. A group with a high electron cloud density is introduced into the paraquat hapten, and after a carrier protein is coupled, the paraquat hapten can be fully exposed to obtain a paraquat complete antigen with strong immunogenicity. The invention discloses a paraquat specific antibody based on the paraquat complete antigen. The paraquat specific antibody has the advantages of high titer, strong specificity and high sensitivity. The paraquat detection test paper comprises a chromatographic membrane and a colloidal gold module, and the colloidal gold module comprises a colloidal gold labeled paraquat specific antibody; and a detection line and a quality control line are sequentially arranged on the chromatographic membrane along the liquid chromatography direction, the detection line is coated with the paraquat complete antigen, and the quality control line iscoated with a binding antibody of the paraquat specific antibody. The paraquat detection test paper can realize sensitive and rapid detection of paraquat residues, is simple in sample pretreatment, and is suitable for large-scale detection.
Owner:SHENZHEN UNIV

Near-infrared quantum dot probe for brain glioma tracing

The invention provides a near-infrared quantum dot probe for the brain glioma tracing. The probe uses a carboxylated poloxamer, and a cyclic glycyl-arginyl-glycyl-aspartyl-asparaginyl-proline short peptide grafted poloxamer as materials, near-infrared quantum dots and a cysteine-alanine-glutamine-lysine tetrapeptide are encapsulated, nanomicelles are formed by the self-assembly in an aqueous solution, and a solution of the near-infrared quantum dot probe that specifically binds to integrin alpha v beta 3 overexpressed by glioma cells is formed. The near-infrared quantum dot probe has the characteristics of uniform particle size, high stability, good tumor targeting, and strong tissue penetration. The brain glioma tracing with high efficiency, targeting and specificity can be realized by combining the ultrasound-targeted micro-bubble blasting technology to reversibly open the blood-brain barrier.
Owner:WENZHOU MEDICAL UNIV
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