Water-soluble anti-cancer photosensitizer and preparation and application thereof
A photosensitizer, water-soluble technology, applied in the field of water-soluble anti-cancer photosensitizers, can solve problems such as poor water solubility, inability to kill tumors, etc., achieve low cost, low skin phototoxicity, high yield and photostability Effect
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[0025] Example
[0026] (1) Dissolve p-aldehyde benzoic acid (1.50 g, 10.0 mmol) and 2,4-dimethylpyrrole (2.38 g, 25.0 mmol) in anhydrous tetrahydrofuran (100 mL), then add 1 drop of trifluoro Acetic acid (TFA), react for 12 h under dark conditions. Accurately weigh a certain amount of DDQ (2.27 g, 10.0 mmol), add anhydrous tetrahydrofuran (50 mL) and sonicate until it is fully dissolved, then add it to the reaction solution and continue the reaction for 4 h, and then place it in an ice bath. Slowly add triethylamine (18 mL, 130 mmol) and boron trifluoride ether (18 mL, 149 mmol) dropwise. After the addition, continue to react overnight under dark conditions. After the reaction, the filtrate was first filtered with diatomaceous earth, and the filtrate was washed three times with water, saturated sodium bicarbonate solution and saturated brine in sequence, and the organic layers were combined, fully dried and then spin-dried under reduced pressure. Then use dichloromethane-metha...
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