35results about How to "Suitable for synthesis" patented technology

An organic fertilizer suitable for tomato growth is characterized by being composed of the following raw materials in parts by weight: 10 to 15 parts of rotten tree bark, 6 to 8 parts of cotton seed hull, 8 to 10 parts of peanut hull, 6 to 10 parts of dry cow manure, 16 to 20 parts of dry mud, 4 to 6 parts of zeolite powder, 0.05 to 0.08 part of biological fermentation inoculant, 1 to 2 parts of calcium bicarbonate, 0.2 to 0.4 part of sodium humate, 0.1 to 0.3 part of fulvic acid, 0.04 to 0.06 part of manganese sulfate, 0.02 to 0.05 part of ferrous sulfate, 2 to 3 parts of urea, 0.4 to 0.5 part of auxiliary agent, and a proper amount of water. The fertilizer is suitable for tomato growth, and is prepared by fermenting rotten tree bark, cotton seed hull and peanut hull and then adding inorganic materials into the fermented mixture. Chemical agents are added so as to implement elements (N, P, and K) which are required during the plant growth process. The organic fertilizer must be the development core of fertilizers in the future.

The invention relates to a synthesis and purification method for an alpha-amino acid compound. The synthesis and purification method is characterized by comprising the following steps: (1) adding substituted alpha-amino nitrile or a substituted hydantoin-based compound into alkali M(OH)x or metal oxide MxO, adding water or an alcohol and water mixed solvent, and heating for reaction to obtain alpha-amino acid salt; (2) adding ammonium carbonate or ammonium bicarbonate or introducing carbon dioxide into the solution in the step (1), separating to obtain filter liquor and precipitates MxHyCO3, performing reduced pressure concentration on the filter liquor, and recrystallizing in an alcohol solvent to obtain the alpha-amino acid compound (I). The synthesis and purification method for the alpha-amino acid compound is simple, the yield and purity of the obtained alpha-amino acid compound are high; furthermore, recycling utilization and cleaning production of materials can be realized; the synthesis and purification method is especially suitable for synthesis of the alpha-amino acid compound with high water solubility.

The present invention discloses a hypothermal alkali liquation synthesis process of monocrystalline nanometer materials of oxygenous metal inorganic compounds. The compound oxide monocrystalline nanometer materials are synthesized with the inorganic salt of a metal and the oxide of another metal as main materials, melted mixed alkali as solvent, at atmospheric pressure and relatively low temperature of about 200DEG C. The present invention uses melted alkali as solvent for the first time and can synthesize oxide nanometer materials of different structures, compositions and functions, or monocrystalline nanometer materials of simple oxide and hydroxide. This process utilizes conventional materials and only controls the time and temperature during synthesis in favor of the industrial application. The produced monocrystalline nanometer materials includes ferroelectric and piezoelectric materials, ferromagnetic materials, semiconductive materials, ionic conductive materials, colossal magnetoresistance materials, high dielectric materials superconductors and etc. that can be applied to microelectronics, photoelectronics and communication.

The invention belongs to the field of solar batteries, and particularly relates to a preparation method of slurry for a photoanode of a nano TiO2 membrane of a dye-sensitized solar cell. The method aims at solving the technical problem that the existing preparation method of the slurry required by a nano TiO2 photoanode membrane is higher in cost and complicated in technology. In order to solve the technical problem, the preparation method of the slurry for the photoanode of the nano TiO2 membrane of the dye-sensitized solar cell comprises the following steps of: a, heating commercial titanium liquid for hydrolysis, performing centrifugal settling on a hydrolysis system, removing supernatant, washing and obtaining metatitanic acid, b, adding a dispergator into metatitanic acid for dispergation, obtaining metatitanic acid slurry, and c, adding an additive to allow the metatitanic acid slurry to be dispersed uniformly. The method is simple to implement; performances of the slurry can be flexibly adjusted according to technological parameters; the obtained metatitanic acid slurry is good in dispersity and strong in stability; and a new method is provided for preparing the slurry for the photoanode of the nano TiO2 membrane of the dye-sensitized solar cell.

The invention discloses a method for preparing aryl boronate represented by a formula I at a room temperature. The method comprises: carrying out a reaction on a diboron compound represented by a formula II and an aryl halide in an organic solvent for 0.5-8 h at a room temperature under the actions of an alkali, a chloro(2-dicyclohexylphosphino-2',4',6'-tri-isopropyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium (II) catalyst and a 2-dicyclohexylphosphine-2',4',6'-triisopropylbiphenyl ligand, and carrying out post-treatment to obtain the corresponding aryl boronate. According to the present invention, the method has characteristics of mild reaction conditions, simple operation, wide application range, good compatibility with various functional groups on aryl, high efficiency and economy, can achieve high yield of aryl borate under normal pressure and normal pressure conditions, and is suitable for large-scale preparation of aryl borate. The formulas I and II are defined in the specification, wherein R' represents any one selected from phenyl with substituent, pyridyl, thienyl, indyl, pyrazolyl and naphthyl.

The invention belongs to the field of organic synthesis, fine chemicals and daily chemicals, and particularly relates to a synthetic method of hydroxypropyl tetrahydropyrantriol catalyzed by a biological enzyme. According to the method, a double-enzyme circulating catalysis system containing aldoketo reductase (AKR) and ethanol dehydrogenase (ADH) is used, and in the presence of oxidized coenzyme II (NADP), isopropanol is used as a reducing agent, so that the synthesis of the hydroxypropyl tetrahydropyrantriol is realized. As biological enzyme catalysis is adopted, the method is mild in condition, simple and convenient to operate, small in pollution, green, safe, free of metal residues and high in product purity, and is particularly suitable for synthesis of active matters of medicines and cosmetics.

The invention provides a preparation method of dipropylmalonic acid diester. The method comprises the following steps: in an organic reaction solvent, alkali is taken as a catalyst, diester malonate and 1-halogenated n-propane are reacted to prepare dipropylmalonic acid diester, a reaction equation is shown as a reaction equation (I), in the reaction equation, R1 and R2 are respectively and independently selected from straight chain or branched chain alkanes with 1-5 carbon atoms; X is halogen; the alkali is MO-R3, wherein the R3 is straight chain or branched chain alkanes with 1-4 carbon atoms, and M is sodium or potassium. Compared with the prior art, the dipropylmalonic acid diester preparation method has the following advantages and active effects: a phase-transfer catalyst is not added in the reaction, the reaction speed is fast, the postprocessing is simple, dipropylmalonic acid diester can be directly used in a next step, and is suitable for synthesis of pharmaceutical intermediates.

This invention relates to 7-phenylacetamide-3-deacetoxycephalosporanate, and a preparation method and an application thereof. The 7-phenylacetamido-3-deacetoxycephalosporanate has the structural formula shown as the specification; M+ is selected from a metal ion or an ammonium ion. The preparation method comprises the steps of: perfomring a reaction on 7-phenylacetamido-3-desacetoxycephalosporanicacid with an alkaline salt forming agent; or performing a reaction on 7-phenylacetamido-3-desacetoxycephalosporin trimethylsilicon ester with an alkaline salt forming agent. 7-ADCA can be prepared from the 7-phenylacetamido-3-desacetoxycephalosporanate. The content of the 7-ADCA product produced is very high, especially the content of the isomer [delta] 2-7-ADCA is less than 0.5%. The product ismore suitable for the synthesis of high quality cephalexin, cefradine, cefadroxil and ceftazidime and other cephalosporin bulk drugs.

The invention relates to synthesis of methyl benzoate, in particular to a synthesis method of methyl benzoate by carbonylation of bromobenzene catalyzed by non-noble metal through photochemical catalysis under mild condition. The method adopts the technical proposal comprising the following steps: filling 0.10-0.15 Mpa CO into a solution consisting of 50-200 mmol / L of bromobenzene, 5-20 mmol / L of Co(OAc)2 or CoCl2 as a catalyst and 100-1,000 mmol / l of alkali additive NaOCH3 or NaOAc, irradiating the solution by a 100-400W high voltage mercury lamp for 1-5 hours, and reacting at a temperature of between 15 and 25 DEG C. Preferably the methanol solution consisting of 50-200 mmol / L of bromobenzene, 5-20 mmol / L of Co(OAc)2 or CoCl2 as a catalyst and 100-1,000 mmol / l of alkali additive NaOCH3 or NaOAc is further added with 50-500 mmol / L of hypnone or benzophenone. The synthesis method has mild reaction condition, catalyzes reaction by simple non-noble metal salt, directly functionalizes bromobenzene, has high yield and selectivity (both can reach 91 percent) of the methyl benzoate, and is suitable for small scale production of methyl benzoate with high added value.

The invention belongs to the technical field of organic synthesis and relates to a method for preparing amino ether compounds. The method comprises the following steps: by taking amino alcohol as a raw material, protecting amino in the amino alcohol so as to obtain Schiff base; carrying out an etherification reaction on the hydroxyl group in the Schiff base; and finally, performing amino deprotection, thereby obtaining corresponding amino ethers. The method disclosed by the invention has high regio-selectivity, the substrates of higher than 99.9% are subjected to etherification reaction, the reaction conversion ratio of each step is higher than 99.8%, and the total yield is higher than 95%; when amino alcohol is chiral, the amino ethers with retention of configuration can be obtained; and moreover, each step of the method is a conventional operation, the process cost is low, and three wastes are few, the energy consumption is low, an environment-friendly effect is achieved, and large-scale industrial production is easily realized.

The invention discloses a method for preparing a noble metal (palladiumpalladium, platinum, silver or gold) decorated nanometer ZnS / polyaniline composite photocatalyst, belonging to the technical field of chemical preparations. The method is characterized in that the photocatalyst is obtained through depositing the noble metals on the surface of the nanometer ZnS / polyaniline composite photocatalyst, and comprises the following steps of: (1) introducing a sulfur source by using a compound of conductive polymer polyaniline and Zn2+ as a matrix and using a coordination coordination conversion method to convert Zn2+ into sulfur-enriched nanometer ZnS among polyaniline links to prepare a composite system of the sulfur-enriched nanometer ZnS / polyaniline; and (2) reacting a noble metal ion with excessive S2-in the composite system of the sulfur-enriched nanometer ZnS / polyaniline to prepare the noble metal decorated nanometer ZnS / polyaniline composite photocatalyst by means of chemical deposition. The invention has the characteristics of convenient methods and no need of expensive equipment, the prepared catalyst has favorable conductivity and stronger photocatalysis, and can be applied to the fields of preparing methanol by catalyzing and reducing carbon oxide, managing environment pollution, sterilizing and the like.

The invention discloses a synthesis method of a drug intermediate, and particularly relates to a preparation method of a cefditoren pivoxil cephalosporins intermediate. The preparation method comprises the step of reacting through phosphorus Ylide-Wittig reaction and hydrolysis reaction by using 7-phenylacetamide-3-chloromethylcephalosporanic acid p-methoxybenzyl ester to obtain cefditoren pivoxil cephalosporins. The preparation method is simple in process, safe, environment-friendly, high in yield, and suitable for industrialized production.

The invention relates to sulfonated Lewis X trisaccharide having the following structural formula as described in the description, wherein R1 is selected from a hydrogen atom, an alpha- or beta-configuration serine residue, an alpha- or beta-configuration threonine residue, an azide-substituted alkyl group, an alkynyl-substituted alkyl group, a sulfydryl-substituted alkyl group, an alpha- or beta-configuration substituted alkyl group; R2 is selected from the hydrogen atom, a sulfonic acid group, a phosphoric acid group and a carbonic acid group. The method has the advantages of less synthesissteps, high reaction selectivity, high yield and good stereoselectivity. In addition, the 3'-sulfonated modified LeX trisaccharide and the natural ligand -SLeX tetrasaccharide of E-Siglec show similaranti-inflammatory activity by anti-inflammatory activity evaluation. Compared with the Lex trisaccharide, the anti-inflammatory activity has significant difference, that is, the sulfonated Lewis X trisaccharide has good anti-inflammatory activity and can be applied in drug development.

The invention discloses a paraquat hapten. The paraquat hapten has a structure represented by formula (I) shown in the description. A group with a high electron cloud density is introduced into the paraquat hapten, and after a carrier protein is coupled, the paraquat hapten can be fully exposed to obtain a paraquat complete antigen with strong immunogenicity. The invention discloses a paraquat specific antibody based on the paraquat complete antigen. The paraquat specific antibody has the advantages of high titer, strong specificity and high sensitivity. The paraquat detection test paper comprises a chromatographic membrane and a colloidal gold module, and the colloidal gold module comprises a colloidal gold labeled paraquat specific antibody; and a detection line and a quality control line are sequentially arranged on the chromatographic membrane along the liquid chromatography direction, the detection line is coated with the paraquat complete antigen, and the quality control line iscoated with a binding antibody of the paraquat specific antibody. The paraquat detection test paper can realize sensitive and rapid detection of paraquat residues, is simple in sample pretreatment, and is suitable for large-scale detection.

The invention discloses a method for synthesizing beta-hydroxymethyl butyrate, which mainly comprises the step of adding methyl formate with a concentration of between 125 and 625mmol / lL into a methanol solution containing propylene oxide with a concentration of between 250 and 1,000mmol / lL and a cobalt acetate and cadmium iodide catalyst with a concentration of between 8 and 16mmol / lL, wherein the molar ratio of cobalt acetate to cadmium iodide is 1: 9, a high-voltage mercury lamp with the power of between 100 and 400W is used to irradiate a reaction liquid for 15 to 55 hours, and the reaction temperature is between 25 and 60 DEG C. Preferably, sodium acetate with a concentration of between 300 and 900mmol / lL is also added into the methanol solution containing the propylene oxide with the concentration of between 250 and 1,000mmol / lL and the catalyst with the concentration of between 8 and 16mmol / lL. The method ensures that a carbonylation reaction gets simple and easy and has safe operation; and a non-precious metal compound adopted as the catalyst is easy to obtain and is also convenient to store and use. The product has low cost, and is suitable for the synthesis of the beta-hydroxymethyl butyrate with small scale and high added value.

The invention discloses a T7-RNA polymerase mutant. The mutant is obtained by replacing serine at the 43rd site from the N end of an amino acid sequence of wild T7-RNA polymerase with A-type amino acid or B-type amino acid, wherein the A amino acid is tyrosine, phenylalanine, leucine, lysine or aspartic acid, and the B amino acid is tryptophan, isoleucine, arginine, asparagine, glutamine, glutamic acid or proline. The T7-RNA polymerase mutant is suitable for synthesis of RNA internally containing a termination signal and RNA with a hairpin structure formed at the tail end. The method can be widely applied to the aspects of in-vitro transcription, RNA synthesis, gene editing, RNA drug synthesis, in-vivo protein expression or cell-free protein expression in-vitro translation systems, transcription terminator research, RNA-dependent RNA polymerase activity research, biological transcription regulation element synthesis and the like.

The invention discloses a synthetic method of a fullerene spiro derivative, and belongs to the technical field of synthesis of fullerene derivatives. According to the technical scheme, the preparationmethod is characterized by comprising the steps of by taking a terminal alkenyl-containing compound of o-iodophenol / o-iodoaniline as a reaction raw material, reacting with fullerene C60 at the temperature of 130-150 DEG C under the catalysis of palladium salt Pd(PPh3)4 and the promotion of cesium salt Cs2CO3 to form three C-C bonds and construct two rings at the same time in a series process of Heck / C-H activation, and directly synthesizing the fullerene spiro derivative with diversified structures by a one-pot method. The method is simple in production process, environmentally friendly, widein substrate application range and high in yield; and the domino strategy of transition metal catalysis used in the production process is not only suitable for synthesis of a spiro structure, but also suitable for synthesis of other complex fullerene derivative structures.

Polyethylene glycol monoallyl ether reacts with a sulfhydryl compound containing an amino group or a carboxyl group to obtain sulfur-containing polyethylene glycol, and the structural general formulais shown in the description. The amino group or the carboxyl group is introduced into polyethylene glycol, so that the modified polyethylene glycol is very conveniently introduced into the resin, andthe polyethylene glycol resin with different effects is obtained.

The invention relates to a method for synthesizing icariin by glucosidation of dehydrated epimedium herb. The conventional method for synthesizing icariin by glucosidation of dehydrated epimedium herb is low in selectivity. For solving the problem, the method uses strontium carbonate as a catalyst and comprises the following steps: dissolving dehydrated icaritin in an organic solvent; reacting the icaritin with alpha-bromotetraacetyl-D-glucopyranose in the presence of strontium carbonate to perform glucosidation at position-3; reacting the product of the glucosidation with alpha-bromotriacetyl-L-rhamnopyranoside in the presence of a silver trifluoromethanesulfonate catalyst to perform glucosidation at position-7; and performing deacetylation reaction to obtain icariin. The method is suitable to synthesize icariin.

The invention relates to a method of C=C bond catalysis transfer hydrogenation reaction, in particular to a method of NiCl2 catalysis 1-octylene transfer hydrogenation reaction under the condition of mild illumination. The method comprises: methanol solution containing 20-100m mol / L of 1-octylene and 5-15 m mol / L of NiCl2 catalyst is irradiated for 10-30h by a high-voltage mercury lamp of 100-400W at the temperature of 15-80 DEG C; if the reaction temperature is 15-25 DEG C, 50-300 m mol / L of tri-n-butylamine is added into the reaction system to improve the activity and selectivity of the reaction; if the reaction temperature is 26-80 DEG C, the tri-n-butylamine is not needed to be added. The method has mild reaction condition, is used for catalyzing simple commercial salt of non-noble metal, avoids using combustible hydrogen as hydrogen source, has high safety and is applicable to the synthesis of fine chemicals with small scale and high added value.

The invention discloses a novel labeling reagent 4-(N,N-dimethylamino)azobenzene-4'-sulfonyl fluoride capable of derivatization reaction with protein and amino acid and its synthesis method and the compound in protein, The application in amino acid analysis, the synthesis method of its intermediate p-acetamidobenzenesulfonyl fluoride and the application of this compound in protein and amino acid analysis. The labeling reagent uses aniline as a raw material to prepare p-acetylaminobenzenesulfonyl fluoride through acetylation, chlorosulfonation and fluorination reactions, and then hydrolyzes the p-acetylaminobenzenesulfonyl fluoride, undergoes diazotization and coupling reactions. The labeling reagent is easy to synthesize, easy to store, derivatizes with primary or secondary amino acids under mild conditions, stable derivatized products, convenient liquid phase or capillary chromatographic separation, high instrument response value, and detection sensitivity up to pmol level. Achieve the effect of chemical derivatization-instrumental detection.

The invention discloses a preparation method of RNA polymerase using RNA as formwork and an application of the polymerase. The preparation method comprises the following steps of using alpha necrosisviruses as a raw material, preparing recombinant protein based on virus replication protein containing a polymerase structural domain and free from N-terminal transmembrane domain or transmembrane domain mutation, and the RNA polymerase having RNA dependence is obtained. The preparation method specially comprises the steps of firstly, selecting alpha necrosis viruses of tomato bushy stunt virusesas the raw material; then removing the N-terminal transmembrane domain of the virus RNA through cutting short or mutation to obtain the formwork RNA; and finally, performing synthesis on the RNA polymerase in cells or outside cells through prokaryotic expression or eukaryotic expression. According to the recombinant protein obtained by the method, the RNA yield is greater than 1 milligram / milliliter, and the preparation method is suitable for synthesis and production of industrial RNA.

The invention discloses a preparation method of a ring brush polymer containing a polystyrene main chain. Particularly, the method comprises the following steps: (1) synthesizing linear polystyrene; (2) carrying out azidation of the linear polystyrene; (3) carrying out ring-closure reaction; (4) carrying out benzyl bromination of annular polystyrene; and (5) synthesizing the annular polystyrene. According to the preparation method, the ATRP reaction, CuAAC reaction and Woh1-Ziegler reaction are perfectly combined for the first time; the grafting density of the polymer is controlled by controlling the feeding ratio of reaction materials; the grafting length is controlled by controlling the reaction time; a series of ring brush polymers containing the polystyrene main chain are successfully prepared; and the controllability of the preparation method of the ring brush polymer is fundamentally achieved.

The present invention discloses a hypothermal alkali liquation synthesis process of monocrystalline nanometer materials of oxygenous metal inorganic compounds. The compound oxide monocrystalline nanometer materials are synthesized with the inorganic salt of a metal and the oxide of another metal as main materials, melted mixed alkali as solvent, at atmospheric pressure and relatively low temperature of about 200DEG C. The present invention uses melted alkali as solvent for the first time and can synthesize oxide nanometer materials of different structures, compositions and functions, or monocrystalline nanometer materials of simple oxide and hydroxide. This process utilizes conventional materials and only controls the time and temperature during synthesis in favor of the industrial application. The produced monocrystalline nanometer materials includes ferroelectric and piezoelectric materials, ferromagnetic materials, semiconductive materials, ionic conductive materials, colossal magnetoresistance materials, high dielectric materials superconductors and etc. that can be applied to microelectronics, photoelectronics and communication.

The invention relates to a method for synthesis of a long-chain fatty acid ester derivative. Specifically, a hydrochloride of glycine methyl ester or glycine ethyl ester is used as a catalyst to catalyze the esterification reaction of long-chain fatty acid. The method includes: subjecting alcohol and long-chain fatty acid to esterification reaction under the action of the catalyst at certain temperature condition, then conducting extraction and precipitation with ethyl acetate, performing flushing with a sodium chloride aqueous solution for purification. A hydrochloride of glycine methyl esteror glycine ethyl ester is adopted as the catalyst, which belongs to a green catalyst, is the development trend of modern chemistry, has the characteristics of no corrosion to the reaction kettle, lowprice, no toxicity and the like, and is suitable for use as a catalyst to produce palmitate and laurate perfume raw materials.

The invention relates to synthesis of methyl benzoate, in particular to a synthesis method of methyl benzoate by carbonylation of bromobenzene catalyzed by non-noble metal through photochemical catalysis under mild condition. The method adopts the technical proposal comprising the following steps: filling 0.10-0.15 Mpa CO into a solution consisting of 50-200 mmol / L of bromobenzene, 5-20 mmol / L ofCo(OAc)2 or CoCl2 as a catalyst and 100-1,000 mmol / l of alkali additive NaOCH3 or NaOAc, irradiating the solution by a 100-400W high voltage mercury lamp for 1-5 hours, and reacting at a temperature of between 15 and 25 DEG C. Preferably the methanol solution consisting of 50-200 mmol / L of bromobenzene, 5-20 mmol / L of Co(OAc)2 or CoCl2 as a catalyst and 100-1,000 mmol / l of alkali additive NaOCH3 or NaOAc is further added with 50-500 mmol / L of hypnone or benzophenone. The synthesis method has mild reaction condition, catalyzes reaction by simple non-noble metal salt, directly functionalizes bromobenzene, has high yield and selectivity (both can reach 91 percent) of the methyl benzoate, and is suitable for small scale production of methyl benzoate with high added value.

The present invention relates to 7-phenylacetamido-3-desacetoxy cephalosporanic acid salt and its preparation method and application. Described 7-phenylacetamido-3-desacetoxy cephalosporanate has the following structural formula: wherein, M + selected from metal ions or ammonium ions. A method for preparing 7-phenylacetamido-3-desacetoxycephalosporanic acid salt, comprising the steps of: reacting 7-phenylacetamido-3-desacetoxycephalosporanic acid with an alkaline salt-forming agent; Or it can be obtained by reacting 7-phenylacetamido-3-desacetoxy cephalosporanic acid trimethylsilyl ester with alkaline salt-forming agent. 7-ADCA can be prepared by 7-phenylacetamido-3-desacetoxycephalosporanate, and the content of the obtained 7-ADCA product is very high, especially the content of the isomer △2-7-ADCA Less than 0.5%, it is more suitable for synthesizing high-quality cephalexin bulk drugs such as cephalexin, cephradine, cefadroxil and ceftazidime pivoxil.

The invention relates to a method of C=C bond catalysis transfer hydrogenation reaction, in particular to a method of NiCl2 catalysis 1-octylene transfer hydrogenation reaction under the condition of mild illumination. The method comprises: methanol solution containing 20-100m mol / L of 1-octylene and 5-15 m mol / L of NiCl2 catalyst is irradiated for 10-30h by a high-voltage mercury lamp of 100-400W at the temperature of 15-80 DEG C; if the reaction temperature is 15-25 DEG C, 50-300 m mol / L of tri-n-butylamine is added into the reaction system to improve the activity and selectivity of the reaction; if the reaction temperature is 26-80 DEG C, the tri-n-butylamine is not needed to be added. The method has mild reaction condition, is used for catalyzing simple commercial salt of non-noble metal, avoids using combustible hydrogen as hydrogen source, has high safety and is applicable to the synthesis of fine chemicals with small scale and high added value.

The invention relates to a method for preparing methyl-carboxylate by photo-promoted carbonylation reaction of chloro alkane on the moderate condition of non-noble metal catalysis, under the catalysis of non-noble metal catalyst cadmium, making chloro alkane and CO or CO2 perform photo- promoted carbonylation reaction in the methanol to produce the methyl-carboxylate which increases one C as compared with the chloro alkane, where the chloro alkane in the reaction is chloro cyclohexane and / or 1-chloro octane; the catalyst is selected from (a) 4-20mmol / L CdI2, (b) combination of 5-20mmol / L CdCl2 and 4-20mmol / L NaI, or (c) combination of 5-20mmol / L Cd(NO3)2 and 4-20mmol / L NaI. And it adopts non-noble metal compound as catalyst and uses chloro alkane as substrate; and the reacting condition is moderate, the cost is low, and it is suitable for small-scale and high-added value methyl-carboxylate synthesis.