31results about How to "Many side effects" patented technology

The invention belongs to the technical field of medicines, and particularly discloses an enteral nutrition preparation containing konjac mannan oligosaccharide and L-glutamine and application thereofin hyperlipoidemia nutritional therapy. When the method is adopted in the nutritional therapy of a hyperlipoidemia rat model, a certain curative effect is realized, no toxic and side effects exist, the preparation method is simple, the preparation raw materials are easy to obtain, and the application prospect is wide.

The invention discloses a method for synthesizing triallyl phosphite, and belongs to the field of technologies for synthesizing compounds. The method includes adding allyl alcohol and acid binding agents into solvents under the protection of nitrogen, then adding phosphorus trichloride into the solvents and carrying out reaction to obtain reaction liquid; carrying out suction filtration on the reaction liquid and washing, drying, decolorizing and concentrating the reaction liquid to obtain the triallyl phosphite. The allyl alcohol is used as a raw material. The reaction temperatures are lower than -8 DEG C under the control when the phosphorus trichloride is dropwise added into the solvents for the dropwise adding time of 3-4 h, then the temperatures are naturally increased until the temperatures reach 0-30 DEG C, and heat-insulation treatment is carried out for 1-2 h. The method for synthesizing the triallyl phosphite has the advantages that the method is simple and is easy to implement, and the triallyl phosphite prepared by the aid of the method is high in yield and purity.

The invention discloses a powdered Pd / SiO2 catalyst, which is composed of the following components in percentage by weight: 90-99.98% of silica gel powder, 0.01-5% of a palladium metal component and 0.01-5% of a cocatalyst, wherein the cocatalyst is one or more of lithium, sodium, potassium, chromium, manganese, zinc, silver, titanium, lead and bismuth, and the granularity of the silica gel powder is 150-500 meshes. The catalyst is applied to the hydrogenation reaction of alkynol compounds with a large molecular weight in a reaction kettle, and can eliminate the defects that a currently used lindlar catalyst is strong in alkalinity, more in side effects such as isomerism and polymerization and the like, high in leftovers rate, small in specific surface, low in adsorptivity, poor in selectivity, and the like. The invention also discloses a preparation method of the powdered Pd / SiO2 catalyst and the application of the powdered Pd / SiO2 catalyst in the hydrogenation reaction of alkynol compounds. While the powdered Pd / SiO2 catalyst is applied to the hydrogenation reaction of alkynol compounds so as to produce enol compounds, the powdered Pd / SiO2 catalyst is high in conversion rate and selectivity.

The invention relates to organic compound synthesis methods, in particular to an N,N-dimethyl tetrahydrofurfuryl amine synthesis method. The method includes steps: 1) mixing reactants with N,N-dimethyl formamide or N,N-dimethylacetamide and formic acid in a reaction vessel, and performing heating reaction; 1) after heating reaction is finished, performing distillation recovery of DMF (dimethyl formamide) or DMAC (dimethylacetamide) and the formic acid, and subjecting residues to vacuum distillation to obtain N,N-dimethyl furfuryl amine which is an intermediate product; 3) subjecting the intermediate product N,N-dimethyl furfuryl amine to catalytic hydrogenation, and distilling to obtain a product of N,N-dimethyl tetrahydrofurfuryl amine. The N,N-dimethyl tetrahydrofurfuryl amine synthesis method has advantages that raw materials are cheap and extensive in source; problems of low furfural yield and difficulty in separation due to instability of furfural acids are avoided, and acidity and reducibility of the formic acid are fully used; high hydrogenation selectivity and catalyst recyclability are realized; mild conditions, easiness in implementation and high raw material utilization rate are realized, and excessive formic acid and N,N-dimethyl formamide or N,N-dimethylacetamide are easy to recover.