31results about How to "Many side effects" patented technology

An organic heterocycle compound series JN-2158 is prepared by organic synthetic reaction. It can be used in medicine field to treat more diseases of people and animal, such as cancers, senitile dementia, psoriasis, cardiovascular diseas, glomerulonephritis, etc and prevent and cure AIDS.

The invention discloses a method for preparing electronic grade gallic acid by using Tara powder as raw material and combining microorganism fermentation method with resin absorption. The method comprises the following steps: fermenting Tara powder with aspergillus niger to prepare raw gallic acid, decoloring the raw gallic acid in ethanol solution, filtrating to obtain filtrate, sending the filtrate through a anionic-cationic exchange resin column, performing reduced pressure evaporation to recycle ethanol until precipitating crystals, cooling, filtrating to obtain refined gallic acid and performing vacuum drying to obtain the electronic grade gallic acid. The contents of Na, Fe, K, Ca, Mg, Cu, Zn, Al and Mn ions are not more than 50ppb. The method has no pollution, high yield and low cost, the resin can be recycled and the method does not damage resin and is applicable to preparing detergent used to wash integrated circuits in electronic industry.

The invention discloses a method for synthesizing triallyl phosphite, and belongs to the field of technologies for synthesizing compounds. The method includes adding allyl alcohol and acid binding agents into solvents under the protection of nitrogen, then adding phosphorus trichloride into the solvents and carrying out reaction to obtain reaction liquid; carrying out suction filtration on the reaction liquid and washing, drying, decolorizing and concentrating the reaction liquid to obtain the triallyl phosphite. The allyl alcohol is used as a raw material. The reaction temperatures are lower than -8 DEG C under the control when the phosphorus trichloride is dropwise added into the solvents for the dropwise adding time of 3-4 h, then the temperatures are naturally increased until the temperatures reach 0-30 DEG C, and heat-insulation treatment is carried out for 1-2 h. The method for synthesizing the triallyl phosphite has the advantages that the method is simple and is easy to implement, and the triallyl phosphite prepared by the aid of the method is high in yield and purity.

The invention discloses a method for producing electronic-grade gallic acid by using tara powder as a raw material through microbial fermentation and resin adsorption. Tara powder is used as raw material to produce electronic-grade gallic acid by microbial fermentation combined with resin adsorption, and Tara powder is fermented with Aspergillus niger to produce crude gallic acid. Then, the ethanol was evaporated under reduced pressure to recover the ethanol until the crystals were precipitated, and the refined gallic acid was obtained by cooling and filtration, and the electronic grade gallic acid was obtained after vacuum drying. Na, Fe, K, Ca, Mg, Cu, Zn, Al, Mn ions are all ≤50ppb. The method has the advantages of no pollution, high yield, low cost, recyclable resin and no damage to the resin, and is suitable for washing integrated circuits with detergent in the electronic industry.

The invention provides a method for synthesizing triallyl phosphate, and belongs to the technical field of compound synthesis. The method comprises the following steps: adding allyl alcohol serving as a raw material and an acid-binding agent into a solvent under protection of nitrogen; then, adding phosphorus oxychloride to react; pumping and filtering the reacting liquid; washing, drying, decoloring and concentrating to obtain triallyl phosphate; controlling the reacting temperature to be less than negative 30 DEG C when the phosphorus oxychloride is dropwise added for 3.4-7.5 hours; and naturally heating to -2-zero DEG C, and stopping reaction. The synthesizing method is simple and easy to operate, and the prepared triallyl phosphate has high yield and high purity.

The invention relates to a method for removing perfluorinated compounds (PFCs) in wastewater through a micro-nano gas-floating coupled electrooxidation device. The method comprises the steps that (S1)a water inlet pump and a micro-nano bubble generation device are started, the gas inlet amount is adjusted to be 0.3-0.7 mL / min, and a milky gas-water mixture reaches a contact chamber of a reactiondevice through a high-speed water outlet diffuser; (S2) a stirrer is started, the pH value of the wastewater is adjusted through acid or base firstly through a chemical adding groove, and then a coagulant is added; (S3) the gas-water mixture reaches a separation chamber subsequently, the PFCs in the wastewater float upwards to the water surface under the effect of coercing and jacking of bubbles and the effect of a small amount of flocculant, and enter an electrooxidation unit from a slag-water mixture outlet, and the wastewater not containing the PFCs is discharged from a water outlet of a separation chamber; (S4) an electrolyte is added into the electrooxidation unit, after a collected PFCs water-slag mixture reaches a certain volume, the current density is adjusted for electrolysis, andpurified water is discharged from the water outlet; and (S5) the wastewater discharged from the water outlet finally enters a water outlet groove and is discharged after reaching the standard.

The invention belongs to the field of glycobiology technology, and specifically relates to a method for the preparation, separation, analysis and identification of N-sugar chains of reductively released glycoproteins and their derivatives. The method for reductively releasing glycoprotein N-sugar chains of the present invention is to first dissolve the glycoprotein in concentrated ammonia water to hydrolyze the sugar chains, and then pass it through NaBH 3 The reduction of CN yields an active amino group (NH 2 ) of sugar amines, this solution is highly versatile and is suitable for neutral N-glycans, acidic N-glycans and neutral N-glycans containing core α-1,3-fucosylation, releasing N-sugar chains are highly stable and will not degrade, allowing direct preliminary analysis. In addition, the present invention provides a method for labeling the obtained N-sugar chain with Fmoc, and also provides a method for separating, analyzing and identifying the N-sugar chain and the Fmoc-labeled N-sugar chain.

The invention belongs to the technical field of medicines, and particularly discloses an enteral nutrition preparation containing konjac mannan oligosaccharide and L-glutamine and application thereofin hyperlipoidemia nutritional therapy. When the method is adopted in the nutritional therapy of a hyperlipoidemia rat model, a certain curative effect is realized, no toxic and side effects exist, the preparation method is simple, the preparation raw materials are easy to obtain, and the application prospect is wide.

The present invention provides a preparation method of palbociclib parent core structure compound, which comprises preparing palbociclib mother represented by formula (I) using cytosine or intermediate 1 or intermediate 2 as starting material Core structure compound; Intermediate 1; Intermediate 2; wherein X is selected from halogen. The method of the invention has wide source of starting materials, simple operation process, few side reactions and high purity, and conforms to modern green industrial production.

The invention discloses a method for synthesizing triallyl phosphite, and belongs to the field of technologies for synthesizing compounds. The method includes adding allyl alcohol and acid binding agents into solvents under the protection of nitrogen, then adding phosphorus trichloride into the solvents and carrying out reaction to obtain reaction liquid; carrying out suction filtration on the reaction liquid and washing, drying, decolorizing and concentrating the reaction liquid to obtain the triallyl phosphite. The allyl alcohol is used as a raw material. The reaction temperatures are lower than -8 DEG C under the control when the phosphorus trichloride is dropwise added into the solvents for the dropwise adding time of 3-4 h, then the temperatures are naturally increased until the temperatures reach 0-30 DEG C, and heat-insulation treatment is carried out for 1-2 h. The method for synthesizing the triallyl phosphite has the advantages that the method is simple and is easy to implement, and the triallyl phosphite prepared by the aid of the method is high in yield and purity.

The invention relates to a method for synthesizing long-chain fatty acid lipid derivatives. Specifically, the hydrochloride of glycine methyl ester and glycine ethyl ester is used as a catalyst to catalyze the esterification reaction of long-chain fatty acids, including alcohol, long-chain The fatty acid is esterified under the action of a catalyst at a certain temperature, and then extracted with ethyl acetate, washed and purified with an aqueous solution of sodium chloride, and the hydrochloride of glycine methyl and ethyl esters is used as a catalyst. It is a green catalyst and is The development trend of modern chemistry has the characteristics of non-corrosive reaction kettle, low price, non-toxic, etc. It is suitable as a catalyst to produce palmitate and laurate fragrance raw materials.

The invention relates to a series of organic heterocyclic compounds, JN-2518 series compounds and their preparation methods and their application in treating and preventing cancer and other diseases. The series of compounds are prepared through organic synthesis reactions and are used in the field of medicine. This series of compounds can specifically inhibit the activity of cell cycle kinases, block cell proliferation, and induce cell apoptosis, thereby effectively inhibiting the growth of various human tumor cells including colon cancer, prostate cancer, breast cancer, and neuroblastoma. The series of compounds have low toxicity and side effects, and can be used to treat various diseases of humans and animals, including the treatment and prevention of malignant tumors, senile dementia, psoriasis, cardiovascular diseases, glomerulonephritis and AIDS.

The invention discloses a method for preparing 7-amino-3-[(1-methylpyrro-lidinio)methyl]-3-cephem-4-carboxylic acid dihydrochloride, which comprises the following steps: imidazole, trimethylchlorosilane and 7-ACA react in a methylene dichloride solvent at a temperature of between 10 and 30 DEG C, and then are filtered; the temperature is reduced, and TMSI is dripped to react; THF is added into the mixture after methylene dichloride is distilled from a reaction feed liquid, and a N-methylpyrrolidine solution is dripped and stirred at a temperature of between 30 DEG C below zero and 25 DEG C below zero to react; methanol is dripped after the reaction, and then concentrated hydrochloric acid or hydriodic acid is dripped to hydrolyze; a hydrolysate is added with the methylene dichloride, and an aqueous phase is obtained through the separation; a yellow aqueous solution is obtained after the aqueous phase is decolored; and then acetone is added into the mixture to be filtered, washed and dried to obtain a 7-MPCA product. The methylene dichloride is distilled, so as to effectively improve the utilization rate of equipment, and the method can improve 30 percent of the utilization rate ofthe equipment compared with a process that the methylene dichloride is not distilled; and imidazole hydrochloride generated by the reaction which affects the subsequent layering and crystallization is filtered, which is favorable for the reaction, and ensures that the yield can reach 100 percent and the purity of a liquid phase is more than 99 percent.

The invention discloses a preparation method of sucrose-6-acetate. Under the action of a supported platinum catalyst, sucrose and 1-acetyl-1H-1,2,3-triazol[4,5-B]pyridine Esterification occurs with high selectivity to generate sucrose-6-acetate, and the product is separated by crystallization in solution; the supported platinum catalyst is expressed as Pt / X / Z-Y, wherein X is selected from N-hydroxyl-ortho Phthalimide, 1-Hydroxybenzotriazole, N-Hydroxymaleimide, N-Hydroxysuccinimide, 2,2,6,6-Tetramethylpiperidine Oxide, Y It is selected from neutral alumina, silica, molecular sieve, kaolin, and Z is selected from pinacol diborate, biscatechol borate, diphenyltetramethylsilane, and hexamethylsilane. The process of the invention avoids the problems of the use of highly toxic reagents and difficulty in solvent recovery in the prior art, and the conversion rate of raw materials and product selectivity can reach more than 90%.

A method for producing 4-propyl-[1,3,2]dioxathiolane-2,2-dioxide comprises an addition reaction, an oxidation reaction and a purifying process. The method concretely comprises the following steps: 1, carrying out the addition reaction: carrying out addition reaction on thionyl chloride and 1,2-pentanediol as reaction raw materials; 2, carrying out the oxidation reaction: adding a sodium hypochlorite and catalyst mixed solution, carrying out the oxidation reaction to obtain a water phase and organic phase co-existence reaction solution, standing the water phase and organic phase co-existence reaction solution for layering, and separating the obtained water phase to obtain the organic phase which is crude 4-propyl-[1,3,2]dioxathiolane-2,2-dioxide; and 3, purifying: carrying out molecular distillation to obtain 4-propyl-[1,3,2]dioxathiolane-2,2-dioxide. The purity of the prepared 4-propyl-[1,3,2]dioxathiolane-2,2-dioxide can be greater than 99.5%, the water content is not greater than 100PPM, the acid value is not greater than 100PPM, and 4-propyl-[1,3,2]dioxathiolane-2,2-dioxide can be added to a battery in order to improve the performances of the battery and prolong the life of the battery.

The invention discloses a powdered Pd / SiO2 catalyst, which is composed of the following components in percentage by weight: 90-99.98% of silica gel powder, 0.01-5% of a palladium metal component and 0.01-5% of a cocatalyst, wherein the cocatalyst is one or more of lithium, sodium, potassium, chromium, manganese, zinc, silver, titanium, lead and bismuth, and the granularity of the silica gel powder is 150-500 meshes. The catalyst is applied to the hydrogenation reaction of alkynol compounds with a large molecular weight in a reaction kettle, and can eliminate the defects that a currently used lindlar catalyst is strong in alkalinity, more in side effects such as isomerism and polymerization and the like, high in leftovers rate, small in specific surface, low in adsorptivity, poor in selectivity, and the like. The invention also discloses a preparation method of the powdered Pd / SiO2 catalyst and the application of the powdered Pd / SiO2 catalyst in the hydrogenation reaction of alkynol compounds. While the powdered Pd / SiO2 catalyst is applied to the hydrogenation reaction of alkynol compounds so as to produce enol compounds, the powdered Pd / SiO2 catalyst is high in conversion rate and selectivity.

The invention relates to organic compound synthesis methods, in particular to an N,N-dimethyl tetrahydrofurfuryl amine synthesis method. The method includes steps: 1) mixing reactants with N,N-dimethyl formamide or N,N-dimethylacetamide and formic acid in a reaction vessel, and performing heating reaction; 1) after heating reaction is finished, performing distillation recovery of DMF (dimethyl formamide) or DMAC (dimethylacetamide) and the formic acid, and subjecting residues to vacuum distillation to obtain N,N-dimethyl furfuryl amine which is an intermediate product; 3) subjecting the intermediate product N,N-dimethyl furfuryl amine to catalytic hydrogenation, and distilling to obtain a product of N,N-dimethyl tetrahydrofurfuryl amine. The N,N-dimethyl tetrahydrofurfuryl amine synthesis method has advantages that raw materials are cheap and extensive in source; problems of low furfural yield and difficulty in separation due to instability of furfural acids are avoided, and acidity and reducibility of the formic acid are fully used; high hydrogenation selectivity and catalyst recyclability are realized; mild conditions, easiness in implementation and high raw material utilization rate are realized, and excessive formic acid and N,N-dimethyl formamide or N,N-dimethylacetamide are easy to recover.