33results about How to "Increased weight yield" patented technology

The invention discloses a method for preparing cefuroxime acid. The method comprises the following steps of: performing a chloride acylation reaction on 7-aminocephalosporanic acid (7-ACA) and methoxyiminofuran acetate serving as raw materials; performing deacetylation to synthesize DCCF; performing nucleophilic addition on the DCCF and chlorosulfonyl isocyanate (CSI) serving as a strong carbamoyl reagent to obtain chlorosulfonyl cefuroxime; and hydrolyzing the chlorosulfonyl cefuroxime to obtain cefuroxime acid. In the preparation method, the preparation process is simple, and the cefuroximeacid is crystallized by adopting aqueous solution, so that the loss of organic solvents is reduced; simultaneously, aids are added selectively in the reaction process to improve the quality of products, so that finished products with high purity and yield and good colors are obtained. The purity of the cefuroxime acid prepared by the method is more than 98.5 percent, and the weight yield is approximately 100 percent.

The invention relates to a synthesis art of a chemical product, in particular to a new synthesis art for 3-deacetyl cefuroxime acid (DCCF). The art of the invention uses SMIA acyl chloride and 3-deacetyl cephalosporin acid (D-7-ACA) as the main synthesis ingredients to replace the SMIA acyl chloride and the 7-ACA, which reduces the chemical reaction process needed in the synthesis, shortens the production cycle, reduces the using solvent species, facilitates the solvent recovery and improves the product synthesis rate.

The invention relates to a method for preparing 17alpha-hydroxyprogesterone. The17alpha-hydroxyprogesterone is prepared by taking 17beta- cyano-5-androstene-17-ol-3,3-diethylene ketal (referred as an intermediate II) as a raw material and dimethylzinc or methylzinc chloride as a reagent; the content of the 17alpha-hydroxyprogesterone by HPLC is above 99.5% and the weight yield is 83-87%. The method comprises the following steps of dissolving the intermediate II in an organic solvent, adding lithium chloride as a catalyst, stirring, raising the temperature to 40-80 DEG C, dropwise adding a toluene solution of dimethylzinc or methylzinc chloride of which the concentration is 2M, and continuing to complete the reaction; and then adding an ammonium chloride solution of which the concentration is 25% to destruct an organic zinc reagent, separating the aqueous layer out and extracting, merging the organic layer and the extract and concentrating the solvent to near dryness, and then adding lower alcohol, stirring, raising the temperature to 40-60 DEG C, adding the acid of which the concentration is 2M, hydrolyzing, adjusting the pH value with a weak base after the reaction is completed, evaporating 90% of the solvent out, adding tap water, cooling and crystallizing to obtain a crude 17alpha-hydroxyprogesterone product; and then carrying out reflux decolorizing on the crude product with activated carbon by virtue of alcohol, and refining to obtain the commercial grade 17alpha-hydroxyprogesterone. The 17alpha-hydroxyprogesterone produced by the method disclosed by the invention has the advantages of good purity and high yield and is economic and environment-friendly, and the solvent can be recycled.

The invention relates to a method for preparing a mixture of ortho vanillin and vanillin, which is applied to the field of medicine synthesis. The method comprises the following steps of: taking guaiacol and chloroform as raw materials; taking carbinol as a medium; reacting under the condition that sodium hydroxide aqueous solution is added; and utilizing acid to adjust the pH value of the obtained products to be at acid level, thereby obtaining the mixture of ortho vanillin and vanillin, wherein the weight ratio of guaiacol to chloroform to carbinol to sodium hydroxide is (40-60): (200-280): (20-45): (50-80); the concentration of the sodium hydroxide aqueous solution is 40-50%; the reaction temperature in the preparing method is 55 DEG C; the holding time is 4 hours; and the pH value is 5-6. The method further comprises the step of steaming carbinol from the mixture and distilling and removing dregs; the process of steaming carbinol comprises the following steps of: pumping and filtering the mixture, carrying out distilling under reduced pressure by a water pump at 40 DEG C and drying the carbinol, thereby obtaining an oily matter; and the oily matter is subjected to distilling under reduced pressure for 30 minutes at 60 DEG C, thereby obtaining oily liquid. According to the method provided by the invention, the yield of total weight is high and the proportion of the ortho vanillin is increased.

The present invention relates to a propylene production method, wherein the problem of ethylene consumption in the prior art is mainly solved with the present invention. The technical scheme comprises that: a material containing 1-butene, 2-butene, isobutane and n-butane is adopted as a C4 raw material, the C4 raw material is respectively subjected to an extraction separation process to obtain a butene stream containing 1-butene and 2-butene, and the butene stream passes through a disproportionation reactor, an ethylene removing tower and a propylene removing tower to obtain the product propylene. The propylene production method can be used for industrial production of preparation of propylene from C4.

A synthetic method of 17alpha-hydroxy-17beta-cyano-steroid compounds is disclosed. The method includes a) dispersing a compound of a formula (I) into methanol, heating the mixture to 30-32 DEG C, adding 3-buten-2-one into the mixture, then adding acetone cyanohydrin into the mixture, fully stirring the mixture, then adding dropwise a prepared aqueous potassium carbonate solution, and maintaining the temperature until the reaction is completed; and 2) cooling the reaction solution to 0-5 DEG C after the reaction is finished, then stirring the reaction solution until a product is completely precipitated, performing suction filtration, washing filter cake with a small amount of water until neutrality, and drying the product to obtain a compound of a formula (II), and a small amount of a compound of a formula (III) and a compound of a formula (IV) which are adopted as byproducts. The weight ratio of the compound of the formula (I), the methanol, the 3-buten-2-one and the acetone cyanohydrin is 100:90-110:0.9-1.1:80-90. The weight-to-volume ratio of the compound of the formula (I) to the potassium carbonate solution is 100:90-110. The weight percentage of the potassium carbonate solution is 2.5-3.5%.

The invention belongs to the technical field of medicine synthesis and especially relates to a production process of chlorcyclizine hydrochloride. The production process comprises the following steps:a bromination reaction; a condensation reaction; distillation; acid and alkali adjustment; crystallization; refining and purifying; and packaging. The production process has the advantages of simpleprocess, few synthesis steps, cheap and easily available raw materials, mild reaction conditions, strong operability, capacity of realizing continuous production, high total yield and suitability forlarge-scale industrial production. Three recrystallization operations are carried out in the process of refining and purifying, so an impurity content is reduced, the purity of chlorcyclizine hydrochloride reaches relevant weight standards prescribed in Pharmacopeia, and the purity of chlorcyclizine hydrochloride is remarkably improved; and meanwhile, refining yield is improved, and production efficiency can be remarkably improved.

The invention provides a synthesis method of a cefoxitin sodium key intermediate, and belongs to the technical field of heterocyclic compounds. The method comprises the following steps: by taking a cephalotin solution as a treatment object, adding organic alkali, adding a halogenating agent, carrying out halogenating methoxyl reaction, adding acetic acid and saline water, regulating acid and layering, drying an organic layer, concentrating, adding cyclohexylamine to form salt, filtering and drying to obtain a key intermediate 7-alpha methoxyl cephalothin cyclohexylamine salt According to the method, one-step synthesis of the 7-alpha methoxyl cephalothin cyclohexylamine salt is realized, subsequent main impurities of cefoxitin sodium are effectively reduced from the source, the quality and purity of the product are improved, the competitiveness of the cefoxitin product is improved, the product is stable and reliable, the yield is high, the synthesis process is greatly simplified, and the method has an industrial prospect.

The invention relates to a Method for preparation of erythrocin salt, especially a method on using erythrocin to prepare phosphoric acid erythrocin. The characters are: dissolving erythrocin in organic solventn or water of c2-c6 containing hydroxyl group and carbonyl group, agitating, controlling the reaction temperature of forming salt, carrying through synthesize reaction by dripping phosphoric acid solution to regulate the solution's pH value and control reflecting terminal, finally, getting phosphoric acid erythrocin finished product after separation and desiccation. Its technology is advanced, the hazardness for people and circumstance is small, the productivity is high, the cost is low.

The invention relates to a method for producing propylene from C5 and mainly aims at solving the problem of low yield of propylene by weight in the prior art. The problem is well solved by use of the following technical scheme: the method for producing propylene from C5 is adopted and cracked C5 and ethylene are taken as raw materials; the method comprises the following steps: feeding the cracked C5 fraction into a cyclopentadiene removal unit, feeding a C5 material flow removed from the cyclopentadiene and obtained after reaction separation into a selective hydrogenation reactor, performing selective hydrogenation on a diolefin to obtain monoolefines in the presence of a hydrogenation catalyst and hydrogen, mixing the obtained monoolefine C5 material with the ethylene, next, treating by use of an adsorbent, performing a contact reaction on the obtained adsorbed material flow in the presence of an isomerization catalyst and a disproportionation catalyst to obtain a material flow containing the product propylene and the non-reacted ethylene and C5, and separating to obtain the propylene; and the method is applicable to the industrial production of producing propylene from C5.