8 results about "Glycine ethyl ester" patented technology

The invention relates to the technical field of preparation of organic compounds, in particular to a spiro [1-benzofuran-3-ketone-2, 3 '-pyrrolidine] compound and a preparation method of the spiro [1-benzofuran-3-ketone-2, 3'-pyrrolidine] compound. According to the method, an aurone compound derived from 1-benzofuran-3-one and imine derived from glycine ethyl ester are used as raw materials, metal salt and alkali react with imine at room temperature to convert into an methylenimine ylide intermediate, and then the methylenimine ylide intermediate and aurone are subjected to [3 + 2] cycloaddition reaction to obtain the spiro [1-benzofuran-3-one-2, 3 '-pyrrolidine] compound. The used reaction raw materials are simple and easy to obtain, the reaction process conditions are mild, post-treatment is simple and convenient, the substrate applicability is wide, and the prepared spiro [1-benzofuran-3-one-2, 3 '-pyrrolidine] compound is high in yield.

The application discloses a preparation method of D,L-methionine, which comprises the following steps: mixing glycine ethyl ester hydrochloride, benzaldehyde and a solvent, heating to 40-50 DEG C, opening a negative pressure and a reflux water separation device, keeping the system outside steam by adjusting the negative pressure, and dropping triethylamine; solid-liquid separation is performed on the reaction solution, the liquid is heated to reflux, 2-chloroethyl methyl sulfide is dropped, and reflux reaction is continuously performed; the temperature of the reaction solution is reduced to less than or equal to 60 DEG C, the reflux is stopped, and hydrogen chloride gas is introduced; solid-liquid separation is performed on the reaction solution, the liquid is heated to reflux, hydrochloric acid is dropped, and reflux hydrolysis reaction is performed; the reaction solution is subjected to rotary evaporation, the remaining material is washed and dried to obtain D,L-methionine. The application adopts the mode of amino protection and removal, avoids the use of cyanide and high-temperature and high-pressure reaction, is safe and environment-friendly in the whole process, has high reaction selectivity, has few side reactions, and the by-products and the solvent are easy to separate, so that the cost is further reduced, and the industrialization popularization is facilitated.

The invention provides a cooling agent WS-5 production line. The cooling agent WS-5 production line comprises a feeding module, a reaction module and a purification module, the feeding module comprises a raw material tank area, an alkaline water ingredient metering tank, a glycine ethyl ester hydrochloride water ingredient metering tank, a petroleum ether metering tank and a menthyl chloride metering tank; the reaction module comprises a multi-stage continuous reactor and a reaction liquid intermediate tank; the purification module comprises extraction equipment and distillation desolvation equipment, the cooling agent WS-5 production line can be used for continuous production of the cooling agent WS-5, and compared with an existing intermittent production mode, the safety and the production efficiency are greatly improved. Meanwhile, the invention further provides a production process of the cooling agent WS-5.

This invention relates to the field of feed additive preparation technology, and proposes a method for preparing ethyl guanidine hydrochloride, comprising the following steps: S1, dissolving glycine ethyl ester hydrochloride in a solvent, adjusting the pH to 10-11 at 0-5°C using an alkaline adjuster to obtain a reaction solution containing free glycine ethyl ester; S2, adding a cyanamide aqueous solution to the reaction solution containing free glycine ethyl ester at 0-5°C, and reacting at 55-80°C to obtain a reaction solution; S3, after cooling the reaction solution, adjusting the pH to 6-7 using an acidic adjuster, precipitating a solid, which is then filtered and washed to obtain crude ethyl guanidine hydrochloride; S4, recrystallizing the crude ethyl guanidine hydrochloride to obtain ethyl guanidine hydrochloride. This technical solution solves the problems of low yield and low purity of ethyl guanidine hydrochloride in related technologies.

The application discloses a continuous synthesis method of benzylaminoethyl acetate. The continuous flow synthesis method can realize accurate control of reaction conditions, improve the selectivity and purity of products. In addition, the continuous flow synthesis method feeds the reactants at a suitable rate, avoids violent reaction under high concentration, and improves the safety of the production reaction. By designing a continuous flow micro-reaction module, glycine ethyl ester hydrochloride and a catalyst triethylamine are dissolved in toluene under a nitrogen atmosphere to obtain a homogeneous material A; another reactant benzaldehyde is material B. By adjusting the liquid flow meter, the feeding rate of A is adjusted to 36.96 ml / min, and the feeding rate of material B is controlled to 4.41 ml / min by a liquid plunger pump. After material A and material B are continuously synthesized in the micro-reaction module, the products flow into the product storage tank.

The invention discloses a glycine ethyl ester hydrochloride synthesis method, which comprises: (1) adding glycine and absolute ethyl alcohol into a reactor, continuously introducing dry hydrogen chloride, carrying out pre-reaction treatment, and carrying out final reaction treatment; (2) cooling the reaction liquid, and then carrying out centrifugal separation treatment; (3) adding a water removal agent into the reaction mother liquor, carrying out water removal treatment, then carrying out centrifugal separation treatment to obtain a solid, namely the water-absorbed water removal agent, and an obtained filtrate, namely the water-removed mother liquor, and supplementing absolute ethyl alcohol into the water-removed mother liquor for recycling; and (4) carrying out regeneration treatment on the water removal agent after water absorption. According to the novel method for synthesizing glycine ethyl ester hydrochloride, high-temperature backflow is not needed, a water-carrying agent is not introduced, a solvent and water do not need to be separated from mother liquor through rectification, water in the reaction mother liquor is removed through a water removal agent at the room temperature, the mother liquor obtained after water removal can be recycled, and the water removal agent can be regenerated and reused.

The invention discloses a synthetic method of efficient (R)-(2-(4-((6-chlorobenzoxazole-2-yl) oxy) phenoxy) propionyl) glycine ethyl ester. (R)-2-(4-((6-chlorobenzoxazole-2-yl) oxy) phenoxy) propionic acid, methylsulfonyl chloride and glycine ethyl ester hydrochloride are used as raw materials, and high-yield and high-purity (R)-(2-(4-((6-chlorobenzoxazole-2-yl) oxy) phenoxy) propionyl) glycine ethyl ester is obtained by a one-pot method under the catalysis of an acid-binding agent. The method is a one-pot reaction method, has the advantages of simple process, mild reaction conditions, convenience in operation, no need of dangerous reagent thionyl chloride, phosgene and other raw materials, few three wastes, safe and environment-friendly operation process, relatively cheap and easily available raw materials, low reaction cost and suitability for industrial production, and is a green process route.

The present invention relates to the technical field of organic synthesis, and in particular to a synthetic method for 1-amino-2-methyl-2-propanol, comprising the steps of: adding glycine ethyl hydrochloride to an organic solvent, reacting with di-tert-butyl dicarbonate under alkaline conditions to prepare compound compound III; reacting compound III with a Grignard reagent to prepare compound IV; and reacting compound IV with trimethylchlorosilane to prepare 1-amino-2-methyl-2-propanol. The present invention uses cheap glycine ethyl hydrochloride as a raw material, first protects the amino group with Boc, then reacts with a Grignard reagent and an ester to generate a tertiary hydroxyl group. The method is simple to operate, has a high yield, and is suitable for large-scale production.