Absorbable medical hemostatic material and preparation process thereof

A hemostatic material and preparation process technology, applied in the field of medical materials, can solve the problems to be further improved, and achieve the effects of good market application prospects, safe and reliable use, and strong anti-infection ability.

Inactive Publication Date: 2016-11-23
林春梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many kinds of absorbable hemostatic materials, their hemostatic effect, hemostatic efficiency, degradability and biocompatibility need to be further improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] An absorbable medical hemostatic material, prepared from the following components in parts by weight: 18 parts of fish scale collagen, 10 parts of maltodextrin, 5 parts of mannuronic acid oligosaccharides, 3 parts of potassium alginate, D- 2 parts of threitol, 4 parts of polycaprolactone, 1 part of 0.7mol / L alcoholic extract of Angelica dahurica, 1.5 parts of oxaloacetic acid, 2 parts of carboxylated dextran, 1.8 parts of γ-polyglutamic acid, ethyl glycinate 0.5 parts, 1.2 parts of sodium D-glucuronate, 0.3 parts of microcrystalline cellulose 101, 1.8 parts of L-guluronic acid pentasaccharide, 0.4 parts of citric acid, and 55 parts of distilled water.

[0025] The preparation process of the absorbable medical hemostatic material comprises the following preparation steps:

[0026] Step 1) weighing according to the above weight ratio;

[0027] Step 2) Dissolve citric acid and γ-polyglutamic acid in 1 / 2 distilled water, then add fish scale collagen and maltodextrin, heat ...

Embodiment 2

[0032] An absorbable medical hemostatic material, prepared by the following components in parts by weight: 26 parts of fish scale collagen, 19 parts of maltodextrin, 11 parts of mannuronic acid oligosaccharides, 7 parts of potassium alginate, D- 5 parts of threitol, 9 parts of polycaprolactone, 4 parts of 0.7mol / L alcoholic extract of Angelica dahurica, 3.8 parts of oxaloacetic acid, 6 parts of carboxylated dextran, 4 parts of γ-polyglutamic acid, ethyl glycinate 2.3 parts, 3.5 parts of sodium D-glucuronate, 2 parts of microcrystalline cellulose, 3 parts of L-guluronic acid pentasaccharide, 1.6 parts of citric acid, and 85 parts of distilled water.

[0033] The preparation process of the absorbable medical hemostatic material comprises the following preparation steps:

[0034] Step 1) weighing according to the above weight ratio;

[0035] Step 2) Dissolve citric acid and γ-polyglutamic acid in 1 / 2 distilled water, then add fish scale collagen and maltodextrin, heat and stir t...

Embodiment 3

[0040] An absorbable medical hemostatic material, prepared from the following components in parts by weight: 19 parts of fish scale collagen, 12 parts of maltodextrin, 7 parts of mannuronic acid oligosaccharides, 3.5 parts of potassium alginate, D- 2.6 parts of threitol, 4.5 parts of polycaprolactone, 1.5 parts of 0.7mol / L alcoholic extract of Angelica dahurica, 1.9 parts of oxaloacetic acid, 2.4 parts of carboxylated dextran, 2.1 parts of γ-polyglutamic acid, ethyl glycinate 0.8 parts, 1.4 parts of sodium D-glucuronate, 0.4 parts of microcrystalline cellulose 101, 2 parts of L-guluronic acid pentasaccharide, 0.5 parts of citric acid, and 62 parts of distilled water.

[0041] The preparation process of the absorbable medical hemostatic material comprises the following preparation steps:

[0042] Step 1) weighing according to the above weight ratio;

[0043] Step 2) Dissolve citric acid and γ-polyglutamic acid in 1 / 2 distilled water, then add fish scale collagen and maltodextr...

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PUM

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Abstract

The invention discloses an absorbable medical hemostatic material and a preparation process thereof. The hemostatic material is prepared from the following components: fish scale collagen protein, maltodextrin, oligomannuronate, potassium alginate, D-threitol, polycaprolactone, 0.7 mol/L radix angelicae and alcohol extract, oxaloacetic acid, carboxyl glucan, gamma-polyglutamic acid, glycine ethyl ester, sodium D-glucuronate, microcrystalline cellulose 101, L-pentaguluronic acid pentasodium salt, citric acid and distilled water. The hemostatic material provided by the invention can stop bleeding quickly, is high in hemostasis rate, is higher in degrading speed in vivo, is non-toxic and high in biocompatibility, does not have immunoreactions, is high in capacity of healing and recovering a wound, can be used safely and reliably, and has a good market application prospect.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an absorbable medical hemostatic material and a preparation process thereof. Background technique [0002] Rapid and effective hemostasis is an important link in clinical operations and first aid for war wounds. At present, there are as many as several hundred tons of various hemostatic drugs used clinically in my country every year, and the trend is increasing year by year. Traditional wound hemostatic materials are mostly non-absorbable. Although they have a certain hemostatic effect, they are prone to infection and other complications in the surgical area. In recent years, research on absorbable hemostatic materials has attracted extensive attention from various countries. [0003] An ideal absorbable hemostatic material must not only have good hemostatic properties, be degradable in vivo, not affect tissue healing, and not increase the probability of i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/04A61L24/00
CPCA61L24/102A61L24/0005A61L24/001A61L24/0042A61L24/046A61L24/08A61L2400/04C08L89/00C08L3/02C08L5/04C08L5/02C08L1/04C08L67/04C08L77/04
Inventor 林春梅
Owner 林春梅
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