Half-range charge-complementary chiral self-assembled short peptide nano-biomedical materials and their applications

Abstract

The invention discloses a half-path charge complementary type chiral self-assembled short-peptide nanometer biomedical material and application. The general formula of the amino acid sequence of a chiral self-assembled short peptide provided in the invention is shown as follows: Ac-Pro-X-Phe-Y-Phe-Asn-Phe-Gln-Pro-NH2, wherein X and Y are polar charged amino acids, X is an negatively charged amino acid and Y is an positively charged amino acid, the amino acids of the whole peptide chain are all D-amino acid, and the number of amino acid residues is set as 9. The half-path charge complementary type chiral self-assembled short peptide has a secondary structure with relatively strong stability and is hardly influenced by external environmental factors, the self-assembly morphology of the chiral short peptide can be regulated by adding NaCl or changing the content of NaCl, and nanometer fiber hydrogel, which has rapid bleeding-stopping effect on bleeding wound, can be formed through self assembly. The material is simple and practicable in preparation technology and relatively low in cost, and the application of the material helps to enrich the kinds of nanometer biomedical materials.

Description

technical field [0001] The invention relates to the field of self-assembled nano biomedical materials, in particular to a class of half-course charge-complementary chiral self-assembled short peptides and their application in rapid hemostasis. Background technique [0002] Due to the fact that the phenomenon of self-assembly exists widely in nature, the design of self-assembled peptide nanomaterials using amino acid residue sequences has gradually become a hot research field in recent years. By rationally designing the amino acid residue sequence of the polypeptide chain, polypeptide molecules can use non-covalent bonding forces such as electrostatic interaction, hydrophobic interaction, hydrogen bond interaction, and π-π stacking interaction to spontaneously or trigger self-assemble to form specific structures and shapes. self-assembly. Since D-amino acids have good biocompatibility and are not easy to be degraded by naturally occurring amino acid decomposing enzymes, the ...

AI Technical Summary

Problems solved by technology

At present, a small number of short peptides with hemostatic activity have been reported at home and abroad, but they are limited to full charge complementary short peptides or easily degradable and unstable short peptides composed of all L-amino acids.

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