Preparation and application of a hemostatic sponge with rapid blood absorption and orderly channels

A hemostatic sponge, fast technology, applied in the field of biomedical materials and medical devices, can solve the problems of inability to attach narrow bleeding openings, lack of shape memory, slow blood absorption, etc., to avoid the risk of secondary bleeding, biophase The effect of good volume and continuous hemostatic effect

Active Publication Date: 2022-04-29
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for incompressible and irregular deep wounds such as ballistic wounds and penetrating wounds caused by bullets and sharp objects, narrow bleeding openings cannot be attached; the blood absorption speed is slow, the hemostasis time is long, and it does not have shape memory. Haemostasis with shape recovery blockage

Method used

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  • Preparation and application of a hemostatic sponge with rapid blood absorption and orderly channels
  • Preparation and application of a hemostatic sponge with rapid blood absorption and orderly channels
  • Preparation and application of a hemostatic sponge with rapid blood absorption and orderly channels

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Preparation of methacrylylated hyaluronic acid HAMA:

[0042] Dissolve 1 g of hyaluronic acid raw material with a molecular weight of 200,000 to 400,000 in 90 mL of DMF / water (1:2; v / v) mixed solvent, stir in an ice bath, and prepare a hyaluronic acid solution. 8 mL of methacrylic anhydride MA was slowly added to the hyaluronic acid solution (0.5 mL / min). Use 5M NaOH to adjust the pH, and adjust the pH every half an hour after the MA is added dropwise until the pH is stable (the pH is stable to about 9, about 4-5 hours), and then stir at 4°C for 24 hours (starting from the time when the MA is added) ). Finally, the reaction solution was precipitated with 1L of ethanol and placed at -20°C for 24h. The precipitate was collected by centrifugation at 5000r for 10 min, reconstituted with a small amount of water, dialyzed in water for 3 days, and the dialyzed product was freeze-dried to obtain dry white flocculent HAMA (methacrylylated hyaluronic acid).

[0043] (2) Pr...

Embodiment 2

[0079] (1) Preparation of methacrylylated hyaluronic acid HAMA:

[0080]Dissolve 1 g of hyaluronic acid raw material with a molecular weight of 200,000 to 400,000 in 100 mL of DMF / water (1:3; v / v) mixed solvent, stir in an ice bath, and prepare a hyaluronic acid solution. 10 mL of methacrylic anhydride MA was slowly added to the hyaluronic acid solution (0.5 mL / min). Use 5M NaOH to adjust the pH, and adjust the pH every half an hour after the MA is added dropwise until the pH is stable (the pH is stable to about 9, about 4-5 hours), and then stir at 4°C for 48h (starting from the time when the MA is added) ). Finally, the reaction solution was precipitated with 1L of ethanol and placed at -20°C for 48h. The precipitate was collected by centrifugation at 5000r for 10 min, reconstituted with a small amount of water, dialyzed in water for 3 days, and the dialyzed product was freeze-dried to obtain dry white flocculent HAMA (methacrylylated hyaluronic acid).

[0081] (2) Prepar...

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Abstract

The invention discloses the preparation and application of a hemostatic sponge with fast blood absorption and orderly channels, and belongs to the field of biomedical materials and medical instruments. In the present invention, the methacrylated collagen ColMa, the methacrylated hyaluronic acid HAMA and the photoinitiator are dissolved in water to prepare a sponge precursor solution, and then the obtained sponge precursor solution is poured into a mold, and the mold is heated at a certain speed. Put it into liquid nitrogen until frozen into shape, then irradiate with ultraviolet light for 0.3-1h, and then freeze-dry the sponge cross-linked by ultraviolet light to obtain the hemostatic sponge that absorbs blood quickly. The present invention utilizes the directional freezing technique and the ultraviolet cross-linking technique to finally prepare a composite collagen rapid hemostatic sponge with suitable mechanical properties, capable of rapidly absorbing liquid, and having a shape memory function.

Description

technical field [0001] The invention relates to the preparation and application of a hemostatic sponge with fast blood absorption and orderly pores, and belongs to the field of biomedical materials and medical instruments. Background technique [0002] Uncontrolled hemorrhage is the leading cause of death from accidents and combat injuries, accounting for one-third of pre-hospital deaths over the past three decades. Not only that, but in surgical procedures including cardiovascular, liver, orthopedic and spinal surgery, there is a high possibility of massive bleeding, and therefore, effective hemostatic materials are required for hemostasis. For uncontrollable bleeding, if it can be effectively stopped within 30 minutes, more than 40% of casualties can be avoided. There are many shape memory polymer sponges currently on the market that have been developed as wound dressings or hemostatic agents and have good hemostatic ability, but it may take tens of seconds to restore the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/28C08F299/00C08F2/48A61L24/00A61L24/04C08L55/00
CPCC08J9/28C08F299/00C08F2/48A61L24/043A61L24/0036A61L24/0015A61L24/001A61L24/0042C08J2355/00C08J2201/0484C08J2205/06A61L2400/04A61L2300/418A61L2400/16C08L5/08C08L89/00
Inventor 杨漾陈敬华张燕燕闵元平
Owner JIANGNAN UNIV
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