42results about How to "Efficient hemostasis" patented technology

The invention discloses a polysaccharide composite film for arresting bleeding, which comprises a starch film and a chitosan film, wherein the starch film and the chitosan film form mutually bonded structures through drying after the starch film in a liquid state permeates through the chitosan film in a solid state; and the mass ratio of the starch film and the chitosan film is 0.1-1 to 50-1. The invention further discloses a preparation method of the polysaccharide composite film for arresting bleeding. The preparation method comprises the following steps: preparing chitosan solution; preparing starch solution; placing the chitosan solution into a die for solidification and formation so as to obtain a chitosan film; and adding starch solution on the chitosan film and forming through solidification, so as to obtain the polysaccharide composite film for arresting bleeding. In the invention, when the composite film is used for arresting bleeding, various mechanisms for arresting bleeding can be started at the same time, so as to enable bleeding arresting to be more efficient and safe; besides, the composite film material of the invention can be degradable and absorbable, and also can play effective wound protecting and anti-adhesion effects at the same.

Disclosed is an external natural montmorillonite emergency life-saving hemostatic agent, which adopts natural montmorillonite as raw material; natural montmorillonite is composed of silica, titanium oxide, alumina, ferric oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide; wherein, the total content of silica and alumina is more than 70%; the interlayer spacing of natural montmorillonite is 1.0- 2.0nm; the specific surface area of natural montmorillonite is 30-1000m2/g; the preparation include the steps: a herbal grinder is adopted to crush the massive natural montmorillonite into particles with different sizes; the particle sizes of the particles are 1micron-1mm; the crushed natural montmorillonite or calcium montmorillonite processed with ion-exchange is processed for 1-24 hours under the temperature of 60- 900 DEG C to obtain external natural montmorillonite emergency life-saving hemostatic agent which has the advantages of simple preparation operation, rich raw materials, cheap price, easy obtaining, convenient application and good hemostatic effect.

The invention discloses a medical hemostasis antibacterial dressing. The medical hemostasis antibacterial dressing is prepared from the raw materials in parts by weight: 60 to 80 parts of polyglutamicacid-Pulullan cross-linked polymer, 25 to 35 parts of collagen, 13 to 17 parts of bamboo vinegar powder, 12 to 18 parts of glycollic acid, 6 to 10 parts of garlic polysaccharide, 5 to 15 parts of hyaluronic acid, and 50 to 60 parts of pure water. The invention also discloses a preparation method of the medical hemostasis antibacterial dressing. The medical hemostasis antibacterial dressing of theinvention has excellent performance for covering wounds, helping the wound healing, efficiently stopping bleeding, preventing the bacterial invasion, promoting the tissue restoration and preventing the adhesion, can rapidly absorb the water in the blood when contacting the wound, can keeping the environment wet, and can effectively seal the bleeding wound.

The invention provides a preparation method of a composite artificial bone material. The preparation method includes steps: (1) dissolving PLGA into an organic solvent, adding nano hydroxyapatite and beta-tricalcium phosphate, and well mixing to obtain 3D printing ink; (2) subjecting the 3D printing ink to low-temperature deposition printing by 3D printing equipment, and performing freeze drying to obtain a porous bone scaffold; (3) performing negative-pressure pouring of modified starch solution into the porous bone scaffold, and carrying out freeze drying to obtain the composite artificial bone material; (4) subjecting the composite artificial bone material to irradiation sterilization to obtain an artificial bone finished product. The composite artificial bone material is prepared from PLGA, nano hydroxyapatite, beta-tricalcium phosphate and modified starch by compounding, and the modified starch is capable of quickly and effectively stopping bleeding in a bone surgery process and also promoting osteoblast maturation and differentiation.

The invention discloses a multifunctional mesoporous biological material and a preparation method thereof. The amorphous glass state particulate matter is composed of an external wrapping mesoporous structure and an internal cabbage structure, the diameters of external wrapping annular mesopores are 5-25 nm, and the gap pitch of the internal cabbage structure is 30-200 nm. The main component of the mesoporous biological material is SiO2-B2O3-CaO, and the mesoporous biological material also contains P2O5, CuO, MgO, ZnO, SrO, Li2O, Na2O and/or K2O. A unique mesoporous particle material is prepared by using a microstructure directing agent and adopting a sol-gel method, and the preparation process is simple. The material is used for arterial and venous hemostasis and promoting healing or regenerative repair of soft tissue and bone tissue wounds, has good histocompatibility, and is a biomedical material capable of adjusting inflammatory response in wounds and preventing and treating pathogenic bacteria infection.

The invention discloses a pressure-monitoring cardiac pacemaker pocket compression hemostat, which comprises: a bracket, a compression device, and a connecting rod; the bracket includes a bottom surface, a side arm and an upper arm connected in sequence; The bracket is a semi-enclosed structure; the front end of the upper arm is a retractable structure; the compression device is used for compression to stop bleeding; the compression device is connected to the front end of the upper arm through the connecting rod; the compression device includes a pressure sensor. The compression hemostat provided by the present invention can provide quantified and personalized compression hemostasis, has good hemostasis effect, low infection rate, and good patient experience.

The invention provides porous hydrogel sponge as well as preparation and application thereof. According to the porous hydrogel sponge, the pore structure is controllable, uniform and mutually communicated, the porosity and the specific surface area in the hydrogel sponge are effectively increased, and the water absorption and the hemostasis efficiency of the porous hydrogel sponge are improved. The porous hydrogel sponge is prepared by freeze-drying the porous hydrogel, and the preparation method is simple. The porous hydrogel sponge disclosed by the invention has excellent biocompatibility and degradability, and can be used for quickly and efficiently stopping bleeding of various wounds.

The invention provides a novel medical degradable hemostatic material and a preparation method thereof. According to the preparation method, a dry-heat crosslinking method is adopted to crosslink chitosan and a derivative thereof, and starch and a derivative thereof, a crosslinked sample is made into a microsphere by a method of electrostatic droplet, in the process of preparing the microsphere, asoluble calcium salt solution is used as stationary liquid, calcium ions are complexed on the microsphere, then physical pore-forming is conducted on the microsphere through a method of ultrasound, aporous microsphere sample is dried through supercritical and sprayed mode, the polysaccharide composite hemostatic material prepared by adopting the preparation method has the advantages of both thestarch and the chitosan, the hemostatic ability is high, antibacterial activity is achieved, toxicity and stimulation are avoided, the process is simple, reagent residue is avoided, pollution is avoided, the cost is low, using is convenient, the polysaccharide composite hemostatic material is suitable for fast hemostasis of massive bleeding, irregular parts and viscera, and also can be used as a raw material of anti-adhesion products, hemostasis products and dressing products.

The invention discloses a preparation method of a polyaldehyde dextran/montmorillonite composite rapid hemostatic material. The polyaldehyde dextran/montmorillonite composite rapid hemostatic materialis prepared by taking polyaldehyde dextran and montmorillonite, which have different molecular weights, as raw materials to prepare a mixed solution, and then freezing and drying. The polyaldehyde dextran/montmorillonite composite rapid hemostatic material obtained by the preparation method provided by the invention is characterized in that blood can be rapidly concentrated on wound parts and blood cells are gathered; meanwhile, a blood coagulation system is rapidly activated so that more efficient and rapid hemostasis of the hemostatic material is realized. The material can be prepared intobandage type dressing, adhesive bandages and self-sticking dressing and operation kits and the like, and can be used for carrying out a physical adsorption effect through other antibacterial, wound-healing-promoting and pain-stopping medicines; the hemostatic material is used as a novel medicine delivery carrier and realizes multifunction integration of the hemostatic material.

The invention discloses an amorphous silicon-based material as well as a preparation method and application thereof, and the amorphous silicon-based material comprises the following components in parts by mole: 20 to 60 parts of SiO2, 10 to 30 parts of CaO, 5 to 10 parts of MgO, 0.1 to 5 parts of Na2O and 0.1 to 5 parts of K2O. According to the amorphous silicon-based material disclosed by the invention, through synthesis of the raw materials, efficient and rapid hemostasis of the hemostatic material under rapid wetting is realized, and meanwhile, the material has excellent antibacterial and healing-promoting properties while being biodegraded.

The invention belongs to the field of medicines, and relates to medical application of icaritin, in particular to application of icaritin in preparation of medicines for preventing and treating gastrointestinal hemorrhage. According to the invention, icaritin is respectively researched on gastrointestinal hemorrhage caused by peptic ulcer, gastrointestinal ulcer hemorrhage caused by medicines and gastrointestinal hemorrhage caused by tumor chemoradiotherapy. Research results show that icaritin has an obvious effect of reducing an incidence rate of gastrointestinal hemorrhage caused by various reasons, has an exact curative effect and an obvious effect on gastrointestinal hemorrhage, and is expected to become an efficient and rapid gastrointestinal hemorrhage prevention and treatment medicine.

The invention discloses preparation and application of hemostatic sponge capable of rapidly sucking blood and having ordered pore channels, and belongs to the field of biomedical materials and medical instruments. The preparation method comprises the following steps: dissolving methylacrylated collagen ColMa, methylacrylated hyaluronic acid HAMA and a photoinitiator in water to prepare a sponge precursor solution, pouring the obtained sponge precursor solution into a mold, putting the mold into liquid nitrogen at a certain rate, freezing and forming, then irradiating with ultraviolet light for 0.3-1 hour, and finally, freezing and drying the sponge subjected to ultraviolet crosslinking to obtain the hemostatic sponge capable of rapidly absorbing blood. According to the invention, a directional freezing technology and an ultraviolet crosslinking technology are utilized to finally prepare the composite collagen rapid hemostatic sponge which has proper mechanical properties, can rapidly absorb liquid and has a shape memory function.

The invention discloses a bioactive gynecologic suppository and a preparation method thereof. The preparation method comprises the following steps: uniformly mixing the following components in percentage by mass: 8 percent to 15 percent of a chitosan derivative, 3 percent to 10 percent of bioactive glass, 5 percent to 20 percent of a pore-forming agent and the balance of water, so as to obtain a chitosan compound suspension mixed solution; taking active carbon fiber cloth as a base material and applying voltage to the base material to form a static electric field between the base material and a high-pressure nozzle; spraying the chitosan compound suspension mixed solution on double faces of the base material by the high-pressure nozzle in a high-pressure atomization and spraying manner; then curing and drying to form a bioactive composite material; cutting and slicing the bioactive composite material and rolling to form a bioactive composite roll; sealing and packaging, and sterilizing to obtain the bioactive gynecologic suppository. By adopting a preparation technology combining electrostatic adsorption and high-pressure spraying, the bioactive gynecologic suppository, which has effects of stopping bleeding and promoting better healing and therapeutic effects and can improve the use feeling of patients, is prepared.

The invention provides a self-adaptive degradable hemostatic material and a preparation method thereof. The self-adaptive degradable hemostatic material is prepared from modified diatomite, a cell active oxygen responsive polymer, biomacromolecules and a drug material, wherein the biomacromolecules are selected from one or more of sodium alginate, chitosan, chondroitin sulfate and hyaluronic acid;and the modified diatomite is prepared by reaction of a silane coupling agent and diatomite. The modified diatomite adsorbs the drug through capillarity, electrostatic interaction and hydrogen bonds,and fixes the ROS responsive polymer through a chemical reaction, so that the drug loaded in the modified diatomite is released when the ROS level rises due to a disease reaction during material degradation or at a wound; therefore, the self-adaptive degradable hemostatic material is endowed with drug loading and releasing capabilities; and removing is not needed, the anti-inflammatory wound healing promoting effect continues to be achieved, and automatic degradation is achieved along with the wound healing material.

The invention provides an outdoor activity emergency hemostatic garment which is efficient and easy to operate. The multi-layer calcium-based zeolite fiber hemostatic garment comprises a three-layer structure which sequentially comprises an outermost layer, a middle layer and an innermost layer, wherein the outermost layer is a calcium-based zeolite fiber layer, the middle layer is a hydrophobic fiber layer, and the innermost layer is a hydrophilic fiber layer; and the calcium-based zeolite fiber layer comprises calcium-based zeolite and fibers, and the calcium-based zeolite is independently dispersed on the surfaces of the fibers. According to the hemostatic garment, the operability during use is ensured, and the problem of loss of calcium ions during use is solved, so that the high-efficiency hemostatic property is achieved.