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42results about How to "Efficient hemostasis" patented technology
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Polysaccharide composite film for arresting bleeding and preparation method thereof
InactiveCN102580138AComplete and effective hemostasisThe exact mechanism of hemostasisAbsorbent padsBandagesComposite filmLiquid state
The invention discloses a polysaccharide composite film for arresting bleeding, which comprises a starch film and a chitosan film, wherein the starch film and the chitosan film form mutually bonded structures through drying after the starch film in a liquid state permeates through the chitosan film in a solid state; and the mass ratio of the starch film and the chitosan film is 0.1-1 to 50-1. The invention further discloses a preparation method of the polysaccharide composite film for arresting bleeding. The preparation method comprises the following steps: preparing chitosan solution; preparing starch solution; placing the chitosan solution into a die for solidification and formation so as to obtain a chitosan film; and adding starch solution on the chitosan film and forming through solidification, so as to obtain the polysaccharide composite film for arresting bleeding. In the invention, when the composite film is used for arresting bleeding, various mechanisms for arresting bleeding can be started at the same time, so as to enable bleeding arresting to be more efficient and safe; besides, the composite film material of the invention can be degradable and absorbable, and also can play effective wound protecting and anti-adhesion effects at the same.
Owner:张晓金
Preparation method of natural montmorillonite emergency haemostatic for external use
ActiveCN101390876AEfficient hemostasisGood curative effectHeavy metal active ingredientsAluminium/calcium/magnesium active ingredientsIon exchangeMassicot
Disclosed is an external natural montmorillonite emergency life-saving hemostatic agent, which adopts natural montmorillonite as raw material; natural montmorillonite is composed of silica, titanium oxide, alumina, ferric oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide; wherein, the total content of silica and alumina is more than 70%; the interlayer spacing of natural montmorillonite is 1.0- 2.0nm; the specific surface area of natural montmorillonite is 30-1000m2 / g; the preparation include the steps: a herbal grinder is adopted to crush the massive natural montmorillonite into particles with different sizes; the particle sizes of the particles are 1micron-1mm; the crushed natural montmorillonite or calcium montmorillonite processed with ion-exchange is processed for 1-24 hours under the temperature of 60- 900 DEG C to obtain external natural montmorillonite emergency life-saving hemostatic agent which has the advantages of simple preparation operation, rich raw materials, cheap price, easy obtaining, convenient application and good hemostatic effect.
Owner:杭州沸创生命科技股份有限公司
Medical hemostasis antibacterial dressing and preparation method thereof
PendingCN108478846AHelp wounds healPrevent bacterial attackAbsorbent padsBandagesWound healingHyaluronic acid
The invention discloses a medical hemostasis antibacterial dressing. The medical hemostasis antibacterial dressing is prepared from the raw materials in parts by weight: 60 to 80 parts of polyglutamicacid-Pulullan cross-linked polymer, 25 to 35 parts of collagen, 13 to 17 parts of bamboo vinegar powder, 12 to 18 parts of glycollic acid, 6 to 10 parts of garlic polysaccharide, 5 to 15 parts of hyaluronic acid, and 50 to 60 parts of pure water. The invention also discloses a preparation method of the medical hemostasis antibacterial dressing. The medical hemostasis antibacterial dressing of theinvention has excellent performance for covering wounds, helping the wound healing, efficiently stopping bleeding, preventing the bacterial invasion, promoting the tissue restoration and preventing the adhesion, can rapidly absorb the water in the blood when contacting the wound, can keeping the environment wet, and can effectively seal the bleeding wound.
Owner:薛春玲
Micro-porous starch composite styptic powder and preparation method thereof
InactiveCN106963976AGood biocompatibilityPromote degradationSurgical adhesivesPharmaceutical delivery mechanismAmylasePorous starch
The invention provides micro-porous starch composite styptic powder and a preparation method thereof. The preparation method includes hydrolyzing alpha-amylase and glucoamylase prior to washing, drying and sieving to obtain micro-porous starch, and sufficiently mixing and granulating, by weight, 50-90 parts of micro-porous starch and 10-50 parts of sodium carboxymethyl starch so as to obtain the micro-porous starch composite styptic powder. The micro-porous starch composite styptic powder prepared by the preparation method is efficient in styptic function, can be adhered to the wound surface to form hydrogel on the wound surface and promote healing of the wound surface and has excellent biocompatibility and biodegradability.
Owner:东莞博捷生物科技有限公司 +2
Composite artificial bone material and preparation method thereof
InactiveCN110251726AIncrease viscosityPromote healingTissue regenerationProsthesisLow temperature depositionFreeze-drying
The invention provides a preparation method of a composite artificial bone material. The preparation method includes steps: (1) dissolving PLGA into an organic solvent, adding nano hydroxyapatite and beta-tricalcium phosphate, and well mixing to obtain 3D printing ink; (2) subjecting the 3D printing ink to low-temperature deposition printing by 3D printing equipment, and performing freeze drying to obtain a porous bone scaffold; (3) performing negative-pressure pouring of modified starch solution into the porous bone scaffold, and carrying out freeze drying to obtain the composite artificial bone material; (4) subjecting the composite artificial bone material to irradiation sterilization to obtain an artificial bone finished product. The composite artificial bone material is prepared from PLGA, nano hydroxyapatite, beta-tricalcium phosphate and modified starch by compounding, and the modified starch is capable of quickly and effectively stopping bleeding in a bone surgery process and also promoting osteoblast maturation and differentiation.
Owner:科先医疗科技(苏州)有限公司
Sodium alginate-cuttlebone-hairyvein agrimony extract product blend fiber, and preparation method thereof
ActiveCN104894689ANo side effectsEfficient hemostasisArtifical filament manufactureBiotechnologyFiber
The invention belongs to the technical field of high-molecular chemical material, and relates to a sodium alginate-cuttlebone-hairyvein agrimony extract product blend fiber and a preparation method thereof. The sodium alginate-cuttlebone-hairyvein agrimony extract product blend fiber comprises, by weight, 70 to 82% of sodium alginate, 12 to 20% of cuttlebone, and 6 to 10% of hairyvein agrimony extract product. According to the preparation method, a cuttlebone ultrafine powder slurry, a hairyvein agrimony extract product solution, and a sodium alginate spinning solution are fully mixed, and an obtained mixture is allowed to stand and deaerate so as to obtain a heterogeneous mixed spinning solution; and the sodium alginate-cuttlebone-hairyvein agrimony extract product blend fiber is obtained via spinning. The sodium alginate-cuttlebone-hairyvein agrimony extract product blend fiber is capable of stopping bleeding with high efficiency, astringing dampness and sore, and resisting bacteria; possesses excellent liquid absorptivity and biological activity; is non-toxic and harmless; is high in security; is biodegradable; and possesses a promising application prospect in the fields of medical gauze, hemostatic dressing, cosmetics, and hygienic products.
Owner:山传雷
Multifunctional mesoporous biological material, preparation method and application
PendingCN113511811ASimple preparation processGood tissue compatibilitySurgical adhesivesTissue regenerationSol-gelBiological materials
The invention discloses a multifunctional mesoporous biological material and a preparation method thereof. The amorphous glass state particulate matter is composed of an external wrapping mesoporous structure and an internal cabbage structure, the diameters of external wrapping annular mesopores are 5-25 nm, and the gap pitch of the internal cabbage structure is 30-200 nm. The main component of the mesoporous biological material is SiO2-B2O3-CaO, and the mesoporous biological material also contains P2O5, CuO, MgO, ZnO, SrO, Li2O, Na2O and / or K2O. A unique mesoporous particle material is prepared by using a microstructure directing agent and adopting a sol-gel method, and the preparation process is simple. The material is used for arterial and venous hemostasis and promoting healing or regenerative repair of soft tissue and bone tissue wounds, has good histocompatibility, and is a biomedical material capable of adjusting inflammatory response in wounds and preventing and treating pathogenic bacteria infection.
Owner:ZHEJIANG UNIV
Pressure monitoring type heart pacemaker sac compression haemostat
InactiveCN106108970AReduce the risk of infectionEfficient hemostasisDiagnosticsSurgeryCardiac pacemaker electrodeIn patient
The invention discloses a pressure-monitoring cardiac pacemaker pocket compression hemostat, which comprises: a bracket, a compression device, and a connecting rod; the bracket includes a bottom surface, a side arm and an upper arm connected in sequence; The bracket is a semi-enclosed structure; the front end of the upper arm is a retractable structure; the compression device is used for compression to stop bleeding; the compression device is connected to the front end of the upper arm through the connecting rod; the compression device includes a pressure sensor. The compression hemostat provided by the present invention can provide quantified and personalized compression hemostasis, has good hemostasis effect, low infection rate, and good patient experience.
Owner:李健
A multifunctional hemostat for hepatobiliary surgery
InactiveCN109363746BSolve the following problems in hemostasisIncrease the difficultySurgerySurgical operationHepatogard
Owner:QINGDAO MUNICIPAL HOSPITAL
Hemostasis composition and preparation method therefor
ActiveCN111249518AReduced risk of bleeding to deathAvoid damageSurgical adhesivesPharmaceutical delivery mechanismSurgical HemostasisDivalent metal
The invention provides a hemostasis composition. The hemostasis composition comprises trypsin and zeolite; pore channels of the zeolite are micropores; the zeolite includes divalent metal positive ions; the mass ratio of the trypsin to the zeolite is 1:200-4:10. According to the hemostasis composition, the trypsin and the zeolite are specifically bound, so that the trypsin keeps a certain conformation on the surface of the zeolite, and higher procoagulant activity is obtained, and thereby, the hemostasis composition with an excellent blood coagulation effect is obtained. The hemostasis composition provided by the invention has a simple preparation method, is low in cost, and convenient to use, can be widely used for traumas and surgical hemostasis, and is especially suitable for emergencyhemostasis of hemophilia patients.
Owner:ZHEJIANG UNIV
Porous hydrogel sponge as well as preparation method and application thereof
PendingCN113817214AGood biocompatibilityMild conditions for pore makingPharmaceutical delivery mechanismAbsorbent padsBiocompatibilityNanotechnology
The invention provides porous hydrogel sponge as well as preparation and application thereof. According to the porous hydrogel sponge, the pore structure is controllable, uniform and mutually communicated, the porosity and the specific surface area in the hydrogel sponge are effectively increased, and the water absorption and the hemostasis efficiency of the porous hydrogel sponge are improved. The porous hydrogel sponge is prepared by freeze-drying the porous hydrogel, and the preparation method is simple. The porous hydrogel sponge disclosed by the invention has excellent biocompatibility and degradability, and can be used for quickly and efficiently stopping bleeding of various wounds.
Owner:INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
Medical dressing for hemostasis and preparation method thereof
InactiveCN108553681AGood biocompatibilityPromote degradationPharmaceutical delivery mechanismAbsorbent padsCross-linkPullulan
The invention discloses a medical dressing for hemostasis. The medical dressing for the hemostasis is prepared from the following raw materials in parts by weight: 50 parts of a polyglutamic acid-Pullulan cross-linked polymer, 20 to 30 parts of oat protein, 15 to 25 parts of cod skin collagen peptide, 10 to 20 parts of basophilic transparent keratin particles, 10 to 20 parts of glycolic acid, 5 to10 parts of garlic polysaccharide, and 5 to 15 parts of sodium hyaluronate. The invention further discloses a preparation method of the medical dressing for the hemostasis. The medical dressing for the hemostasis, disclosed by the invention, has good biocompatibility and biodegradability and excellent performance of high-efficiency hemostasis, bacteriostasis, tissue repair promotion and adhesionprevention, and further can quickly absorb water in blood while in contact with wounds, keep the environment moist and effectively close the bleeding wounds.
Owner:INST OF APPLIED CHEM JIANGXI ACAD OF SCI
Medical degradable hemostatic material and preparation method thereof
ActiveCN110538344AMassive absorptionRapid hemostasisSurgical adhesivesPharmaceutical delivery mechanismMicrosphereAntibacterial activity
The invention provides a novel medical degradable hemostatic material and a preparation method thereof. According to the preparation method, a dry-heat crosslinking method is adopted to crosslink chitosan and a derivative thereof, and starch and a derivative thereof, a crosslinked sample is made into a microsphere by a method of electrostatic droplet, in the process of preparing the microsphere, asoluble calcium salt solution is used as stationary liquid, calcium ions are complexed on the microsphere, then physical pore-forming is conducted on the microsphere through a method of ultrasound, aporous microsphere sample is dried through supercritical and sprayed mode, the polysaccharide composite hemostatic material prepared by adopting the preparation method has the advantages of both thestarch and the chitosan, the hemostatic ability is high, antibacterial activity is achieved, toxicity and stimulation are avoided, the process is simple, reagent residue is avoided, pollution is avoided, the cost is low, using is convenient, the polysaccharide composite hemostatic material is suitable for fast hemostasis of massive bleeding, irregular parts and viscera, and also can be used as a raw material of anti-adhesion products, hemostasis products and dressing products.
Owner:NKD PHARMA CO LTD
Balloon catheter through which guide wire can pass under endoscope
PendingCN110339461AEasy to operateSimple and fast operationBalloon catheterGuide wiresBalloon catheterTwo step
The invention relates to a balloon catheter through which a guide wire can pass under an endoscope. The balloon catheter includes a catheter body and a connector; the portion, near the distal end, ofthe catheter body is provided with a balloon, the catheter body is internally provided with an inflation channel and a guide wire channel in the axial direction, and the inflation channel between theproximal end of the catheter body and the balloon is internally provided with a sealing valve; the connector is a three-way tubular member internally provided with a catheter pipeline and a guide wirecannula communicated with the catheter pipeline, the proximal end of the catheter body passes through the catheter pipeline, the two ends of the catheter pipeline are provided with sealing clamping mechanisms to make the catheter body detachably and hermetically connected with the two ends of the catheter pipeline of the connector, and an inlet of the guide wire channel is in the catheter pipeline. According to the detachable balloon catheter, the balloon can be used for sealing without exiting from the airway during a tracheoscopic operation in case of massive hemorrhage to avoid previous complex operation which needs repeated exchange and introduction of the balloon catheter, the two steps of original guide wire inserting and balloon catheter inserting are combined into one, and the more efficient and more accurate hemostasis effect is achieved.
Owner:CANYON MEDICAL INC
Polyaldehyde dextran/montmorillonite composite rapid hemostatic material and preparation method thereof
ActiveCN108114309AEasy to operateEasy to useSurgical adhesivesPharmaceutical delivery mechanismMontmorilloniteWound healing
The invention discloses a preparation method of a polyaldehyde dextran / montmorillonite composite rapid hemostatic material. The polyaldehyde dextran / montmorillonite composite rapid hemostatic materialis prepared by taking polyaldehyde dextran and montmorillonite, which have different molecular weights, as raw materials to prepare a mixed solution, and then freezing and drying. The polyaldehyde dextran / montmorillonite composite rapid hemostatic material obtained by the preparation method provided by the invention is characterized in that blood can be rapidly concentrated on wound parts and blood cells are gathered; meanwhile, a blood coagulation system is rapidly activated so that more efficient and rapid hemostasis of the hemostatic material is realized. The material can be prepared intobandage type dressing, adhesive bandages and self-sticking dressing and operation kits and the like, and can be used for carrying out a physical adsorption effect through other antibacterial, wound-healing-promoting and pain-stopping medicines; the hemostatic material is used as a novel medicine delivery carrier and realizes multifunction integration of the hemostatic material.
Owner:DALIAN UNIV OF TECH
Amorphous silicon-based material and preparation method and application thereof
ActiveCN114524612AEfficient activationEffective hemostatic propertiesSurgical adhesivesPharmaceutical delivery mechanismAmorphous siliconRaw material
The invention discloses an amorphous silicon-based material as well as a preparation method and application thereof, and the amorphous silicon-based material comprises the following components in parts by mole: 20 to 60 parts of SiO2, 10 to 30 parts of CaO, 5 to 10 parts of MgO, 0.1 to 5 parts of Na2O and 0.1 to 5 parts of K2O. According to the amorphous silicon-based material disclosed by the invention, through synthesis of the raw materials, efficient and rapid hemostasis of the hemostatic material under rapid wetting is realized, and meanwhile, the material has excellent antibacterial and healing-promoting properties while being biodegraded.
Owner:深圳市中科海世御生物科技有限公司
Efficient and rapid hemostatic adhesive plaster for nursing in emergency department and preparation method thereof
InactiveCN106266717AEnhance phagocytosisImprove proliferative abilityPharmaceutical delivery mechanismBlood disorderCodonopsisPteroxygonum
The invention discloses efficient and rapid hemostatic adhesive plaster for nursing in the emergency department. The adhesive plaster is prepared from, by weight, 10-18 parts of spina gleditsiae, 3-7 parts of glycerinum, 8-16 parts of honeysuckle, 10-22 parts of cortex cinnamomi, 5-12 parts of fructus lycii, 7-12 parts of radix aconiti carmichaeli, 6-12 parts of agrimonia pilosa ledeb, 1-3 parts of radix arnebiae seu lithospermi, 3-8 parts of girald pteroxygonum roots, 10-15 parts of sapanwood, 1-5 parts of lalang grass rhizome and 3-8 parts of radix codonopsis. A preparation method of the adhesive plaster includes the following steps of S1, weighing spina gleditsiae, glycerinum, honeysuckle, cortex cinnamomi and fructus lycii according to the weight ratio, and making spina gleditsiae, honeysuckle, cortex cinnamomi and fructus lycii sequentially smashed and then mixed with glycerinum to obtain a mixture A; S2, weighing radix aconiti carmichaeli, agrimonia pilosa ledeb, radix arnebiae seu lithospermi, girald pteroxygonum roots, sapanwood and lalang grass rhizome according to the weight ratio, smashing the raw materials and putting the materials in a cooking pot, adding 4-8 folds of water into the cooking pot, and conducting decocting for 1-2 h on high fire. The prepared hemostatic adhesive plaster is good in hemostatic effect, efficient and rapid in hemostasis, resistant to infection and capable of rapidly promoting healing of wounds.
Owner:徐静
Preparation and application of a hemostatic sponge with rapid blood absorption and orderly channels
ActiveCN113754919BHigh swelling rateReduce cascade reaction timeSurgical adhesivesPharmaceutical delivery mechanismUltraviolet lightsMaterials science
The invention discloses the preparation and application of a hemostatic sponge with fast blood absorption and orderly channels, and belongs to the field of biomedical materials and medical instruments. In the present invention, the methacrylated collagen ColMa, the methacrylated hyaluronic acid HAMA and the photoinitiator are dissolved in water to prepare a sponge precursor solution, and then the obtained sponge precursor solution is poured into a mold, and the mold is heated at a certain speed. Put it into liquid nitrogen until frozen into shape, then irradiate with ultraviolet light for 0.3-1h, and then freeze-dry the sponge cross-linked by ultraviolet light to obtain the hemostatic sponge that absorbs blood quickly. The present invention utilizes the directional freezing technique and the ultraviolet cross-linking technique to finally prepare a composite collagen rapid hemostatic sponge with suitable mechanical properties, capable of rapidly absorbing liquid, and having a shape memory function.
Owner:JIANGNAN UNIV
A corn stalk/chitin composite hemostatic sponge and its preparation method and application
ActiveCN110420346BWide variety of sourcesLow costSurgical adhesivesPharmaceutical delivery mechanismEngineeringEpichlorohydrin
The invention discloses a corn stalk / chitin composite hemostatic sponge, a preparation method and application thereof. The method comprises: respectively dissolving corn stalks and chitin in sodium hydroxide / urea solvent by multiple freezing and thawing methods, mixing the two after dissolving, adding epichlorohydrin for cross-linking reaction, standing at low temperature, After dialysis and drying, the corn stalk / chitin composite hemostatic sponge was obtained. The coagulation index of the composite sponge obtained by the invention is only 4.2±0.5%, compared with the coagulation factor of 48.5±0.4% of the medical PVF hemostatic sponge, the hemostatic performance of the composite sponge prepared by the invention is good. Since the raw materials of the composite sponge are green and recyclable biomass resources corn stalks and chitin, not only the agricultural, forestry and marine waste corn stalks and chitin are efficiently utilized, but also the prepared composite sponge is biodegradable and has good cell compatibility. The advantage is that it can avoid the risk of secondary bleeding caused by the removal of the hemostatic material during the application process.
Owner:SOUTH CHINA UNIV OF TECH
Application of icaritin in preparation of medicine for preventing and treating gastrointestinal hemorrhage
PendingCN113368100AReduce the incidence of bleedingEfficient hemostasisOrganic active ingredientsDigestive systemIcariinBiology
The invention belongs to the field of medicines, and relates to medical application of icaritin, in particular to application of icaritin in preparation of medicines for preventing and treating gastrointestinal hemorrhage. According to the invention, icaritin is respectively researched on gastrointestinal hemorrhage caused by peptic ulcer, gastrointestinal ulcer hemorrhage caused by medicines and gastrointestinal hemorrhage caused by tumor chemoradiotherapy. Research results show that icaritin has an obvious effect of reducing an incidence rate of gastrointestinal hemorrhage caused by various reasons, has an exact curative effect and an obvious effect on gastrointestinal hemorrhage, and is expected to become an efficient and rapid gastrointestinal hemorrhage prevention and treatment medicine.
Owner:LUNAN PHARMA GROUP CORPORATION
Cornstalk/chitin compound hemostatic sponge and preparation method and application thereof
ActiveCN110420346AWide variety of sourcesLow costSurgical adhesivesPharmaceutical delivery mechanismFreeze and thawSolvent
The invention discloses cornstalk / chitin compound hemostatic sponge and a preparation method and application thereof. The preparation method comprises the steps that cornstalk and chitin are correspondingly dissolved in sodium hydroxide / urea solvents by adopting a method of multiple-time freezing and thawing, the cornstalk and the chitin are mixed after dissolving, epichlorohydrin is added for a cross-linking reaction, still standing is conducted at the low temperature, drying is conducted after dialysis, and the cornstalk / chitin compound hemostatic sponge is obtained. According to the cornstalk / chitin compound hemostatic sponge, the clotting index is only 4.2+ / -0.5%, compared with medical PVF hemostatic sponge with 48.5+ / -0.4% of blood coagulation factor, the hemostatic performance of theprepared compound sponge is good. Due to the fact that the raw materials of the compound sponge are green recyclable biomass resources of the cornstalk and the chitin, the agricultural and forestry marine wastes of the cornstalk and the chitin are efficiently utilized, the prepared compound sponge further has the advantages of biodegradation and good cytocompatibility, and the risk of secondary bleeding caused by removing of hemostatic materials in the application process can be avoided.
Owner:SOUTH CHINA UNIV OF TECH
hemostatic material
InactiveCN108785735BEfficient hemostasisRapid hemostasisSurgical adhesivesPharmaceutical delivery mechanismMajor bleedingHemostatic function
The invention discloses a hemostatic material which includes a first hemostatic functional layer, a second hemostatic functional layer and a third hemostatic functional layer that are sequentially stacked, wherein the second hemostatic functional layer is respectively fixedly connected with the first hemostatic functional layer and the third hemostatic functional layer; the first hemostatic functional layer includes a first hemostatic component; the second hemostatic functional layer includes a second hemostatic component being an inorganic material with the water absorption characteristic; the third hemostatic functional layer includes a third hemostatic component being an organic material with the water absorption characteristic. The hemostatic material provided by the invention can be used for hemostasis for various bleeding conditions through the arranged three hemostatic functional layers, is wide in application range, efficient and quick in hemostasis treatment, particularly suitable for hemostasis treatment to hemorrhoea caused by main artery and vena cava rupture, and has the effect of quick hemostasis treatment in site.
Owner:SUN YAT SEN UNIV +1
Preparation method of sponge for blood-sucking in anesthesiology department
InactiveCN104043147BEliminate damageWith promoting blood circulation and dispelling stasisAbsorbent padsBlood disorderNepetaSide effect
Owner:崔超
Preparation and application of hemostatic sponge capable of rapidly absorbing blood and having ordered pore channels
ActiveCN113754919AHigh swelling rateShort reaction timeSurgical adhesivesPharmaceutical delivery mechanismPhotoinitiatorPhoto irradiation
The invention discloses preparation and application of hemostatic sponge capable of rapidly sucking blood and having ordered pore channels, and belongs to the field of biomedical materials and medical instruments. The preparation method comprises the following steps: dissolving methylacrylated collagen ColMa, methylacrylated hyaluronic acid HAMA and a photoinitiator in water to prepare a sponge precursor solution, pouring the obtained sponge precursor solution into a mold, putting the mold into liquid nitrogen at a certain rate, freezing and forming, then irradiating with ultraviolet light for 0.3-1 hour, and finally, freezing and drying the sponge subjected to ultraviolet crosslinking to obtain the hemostatic sponge capable of rapidly absorbing blood. According to the invention, a directional freezing technology and an ultraviolet crosslinking technology are utilized to finally prepare the composite collagen rapid hemostatic sponge which has proper mechanical properties, can rapidly absorb liquid and has a shape memory function.
Owner:JIANGNAN UNIV
Medical degradable hemostatic material and preparation method thereof
ActiveCN110538344BMassive absorptionRapid hemostasisSurgical adhesivesPharmaceutical delivery mechanismMedicineAntibacterial activity
The invention provides a novel medical degradable hemostatic material and a preparation method thereof. According to the preparation method, a dry-heat crosslinking method is adopted to crosslink chitosan and a derivative thereof, and starch and a derivative thereof, a crosslinked sample is made into a microsphere by a method of electrostatic droplet, in the process of preparing the microsphere, asoluble calcium salt solution is used as stationary liquid, calcium ions are complexed on the microsphere, then physical pore-forming is conducted on the microsphere through a method of ultrasound, aporous microsphere sample is dried through supercritical and sprayed mode, the polysaccharide composite hemostatic material prepared by adopting the preparation method has the advantages of both thestarch and the chitosan, the hemostatic ability is high, antibacterial activity is achieved, toxicity and stimulation are avoided, the process is simple, reagent residue is avoided, pollution is avoided, the cost is low, using is convenient, the polysaccharide composite hemostatic material is suitable for fast hemostasis of massive bleeding, irregular parts and viscera, and also can be used as a raw material of anti-adhesion products, hemostasis products and dressing products.
Owner:NKD PHARMA CO LTD
A kind of bioactive gynecological embolism and preparation method thereof
ActiveCN106178090BImprove bindingImprove adsorption capacitySurgical adhesivesSuppositories deliveryFiberTherapeutic effect
The invention discloses a bioactive gynecologic suppository and a preparation method thereof. The preparation method comprises the following steps: uniformly mixing the following components in percentage by mass: 8 percent to 15 percent of a chitosan derivative, 3 percent to 10 percent of bioactive glass, 5 percent to 20 percent of a pore-forming agent and the balance of water, so as to obtain a chitosan compound suspension mixed solution; taking active carbon fiber cloth as a base material and applying voltage to the base material to form a static electric field between the base material and a high-pressure nozzle; spraying the chitosan compound suspension mixed solution on double faces of the base material by the high-pressure nozzle in a high-pressure atomization and spraying manner; then curing and drying to form a bioactive composite material; cutting and slicing the bioactive composite material and rolling to form a bioactive composite roll; sealing and packaging, and sterilizing to obtain the bioactive gynecologic suppository. By adopting a preparation technology combining electrostatic adsorption and high-pressure spraying, the bioactive gynecologic suppository, which has effects of stopping bleeding and promoting better healing and therapeutic effects and can improve the use feeling of patients, is prepared.
Owner:四川艾医生医疗科技有限公司
Self-adaptive degradable hemostatic material and preparation method thereof
ActiveCN112516375AGood hemostatic effectSolve the hidden danger of unsafe blood clotsSurgical adhesivesPharmaceutical delivery mechanismRos responsiveEngineering
The invention provides a self-adaptive degradable hemostatic material and a preparation method thereof. The self-adaptive degradable hemostatic material is prepared from modified diatomite, a cell active oxygen responsive polymer, biomacromolecules and a drug material, wherein the biomacromolecules are selected from one or more of sodium alginate, chitosan, chondroitin sulfate and hyaluronic acid;and the modified diatomite is prepared by reaction of a silane coupling agent and diatomite. The modified diatomite adsorbs the drug through capillarity, electrostatic interaction and hydrogen bonds,and fixes the ROS responsive polymer through a chemical reaction, so that the drug loaded in the modified diatomite is released when the ROS level rises due to a disease reaction during material degradation or at a wound; therefore, the self-adaptive degradable hemostatic material is endowed with drug loading and releasing capabilities; and removing is not needed, the anti-inflammatory wound healing promoting effect continues to be achieved, and automatic degradation is achieved along with the wound healing material.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Sodium alginate sea cricket and Agrimony extract blended fiber and preparation method thereof
The invention belongs to the technical field of high-molecular chemical material, and relates to a sodium alginate-cuttlebone-hairyvein agrimony extract product blend fiber and a preparation method thereof. The sodium alginate-cuttlebone-hairyvein agrimony extract product blend fiber comprises, by weight, 70 to 82% of sodium alginate, 12 to 20% of cuttlebone, and 6 to 10% of hairyvein agrimony extract product. According to the preparation method, a cuttlebone ultrafine powder slurry, a hairyvein agrimony extract product solution, and a sodium alginate spinning solution are fully mixed, and an obtained mixture is allowed to stand and deaerate so as to obtain a heterogeneous mixed spinning solution; and the sodium alginate-cuttlebone-hairyvein agrimony extract product blend fiber is obtained via spinning. The sodium alginate-cuttlebone-hairyvein agrimony extract product blend fiber is capable of stopping bleeding with high efficiency, astringing dampness and sore, and resisting bacteria; possesses excellent liquid absorptivity and biological activity; is non-toxic and harmless; is high in security; is biodegradable; and possesses a promising application prospect in the fields of medical gauze, hemostatic dressing, cosmetics, and hygienic products.
Owner:山传雷
Multi-layer calcium-based zeolite fiber hemostatic clothing and manufacturing method thereof
PendingCN113813438AEfficient hemostasisEasy to operateSurgical adhesivesSynthetic resin layered productsFiberComposite material
The invention provides an outdoor activity emergency hemostatic garment which is efficient and easy to operate. The multi-layer calcium-based zeolite fiber hemostatic garment comprises a three-layer structure which sequentially comprises an outermost layer, a middle layer and an innermost layer, wherein the outermost layer is a calcium-based zeolite fiber layer, the middle layer is a hydrophobic fiber layer, and the innermost layer is a hydrophilic fiber layer; and the calcium-based zeolite fiber layer comprises calcium-based zeolite and fibers, and the calcium-based zeolite is independently dispersed on the surfaces of the fibers. According to the hemostatic garment, the operability during use is ensured, and the problem of loss of calcium ions during use is solved, so that the high-efficiency hemostatic property is achieved.
Owner:ZHEJIANG UNIV
A kind of antibacterial hybrid nano flower hemostatic material and preparation method thereof
ActiveCN109701070BIncrease concentrationLarge specific surface areaSurgical adhesivesGiant plateletsPhosphoric acid
The invention discloses an antibacterial hybrid nano flower hemostatic material and a preparation method thereof. The method first utilizes the ordered formation of phosphate and calcium ions on the surface of sodium tripolyphosphate (TPP)-chitosan (CS) nanocomposites. Hybrid nanoflowers were prepared by self-assembly, and then a mussel-like polydopamine coating was constructed on its surface, and silver nanoparticles were generated in situ using the reductive properties of polydopamine. The flower-like multi-level structure can provide high specific surface area and high porosity. Combined with the polydopamine coating on the surface, it has ultra-high hydrophilicity and excellent tissue adhesion, and can quickly absorb water in blood and increase platelet concentration. , The hemostatic performance is significantly improved without generating too much heat. At the same time, polydopamine is directly reduced to generate silver nanoparticles on the surface of nanoflowers in situ, which endows the material with high-efficiency antibacterial effect, and reduces bleeding wound infection while efficiently hemostasis.
Owner:QINGDAO UNIV
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