Medical degradable hemostatic material and preparation method thereof

A hemostatic material and soluble technology, which is applied in the field of new medical degradable hemostatic material and its preparation, can solve the problems of adhesion, insufficient liquid absorption, high price, toxicity of epichlorohydrin cross-linking agent, etc., and improve the product quality. Safety, rapid mass absorption, and the effect of simplifying the treatment process

Active Publication Date: 2019-12-06
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the "Arista" absorbable starch hemostatic microsphere product produced by Medafor in the United States has a good hemostatic effect, it is expensive and as a hemostatic material in the body, its adhesion and liquid absorption are not strong enough. The combination may be potentially toxic

Method used

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  • Medical degradable hemostatic material and preparation method thereof
  • Medical degradable hemostatic material and preparation method thereof
  • Medical degradable hemostatic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 Preparation of medical degradable hemostatic material

[0041] 1. Self-crosslinking: Weigh 10g of chitosan and 20g of sodium starch glycolate and mix them well. After mixing, dry heat treatment at 120°C for 2 hours to obtain a crosslinked sample.

[0042] 2. Preparation of microspheres: Dissolve the cross-linked sample in 1000ml of water, stir and dissolve, and add the solution dropwise to 20% calcium chloride solidified solution by electrostatic droplet method, the voltage is 20kV, and the feeding rate is 300μL / min.

[0043] 3. Microsphere pore making: put the microsphere solution into an ultrasonic instrument for normal temperature ultrasonication, ultrasonic frequency 40kHz, power 1000W, ultrasonication for 20min.

[0044] 4. Drying: The porous microspheres are dried by means of supercritical drying. The conditions of supercritical drying are: temperature 45°C, vacuum degree 8.5MPa.

[0045] 5. Sterilization: The above samples are packaged and sterili...

Embodiment 2

[0046] Embodiment 2 Preparation of medical degradable hemostatic material

[0047] 1. Self-crosslinking: Weigh 10g of carboxymethyl chitosan and 20g of carboxymethyl starch sodium and mix evenly, dry heat treatment at 135°C for 4 hours to obtain a crosslinking sample.

[0048] 2. Preparation of microspheres: Dissolve the cross-linked sample in 2000ml of water, stir and dissolve, and add the solution dropwise to 15% calcium chloride solidified solution by electrostatic droplet method, the voltage is 40kV, and the feeding rate is 200μL / min.

[0049] 3. Microsphere pore making: put the microsphere solution into an ultrasonic instrument for normal temperature ultrasonication, ultrasonic frequency 28kHz, power 1000W, ultrasonic 40min.

[0050] 4. Drying: The above-mentioned porous microspheres are dried by spray drying.

[0051] 5. Sterilization: The above samples are packaged and sterilized to obtain a medical degradable hemostatic material.

Embodiment 3

[0052] Embodiment 3 Preparation of medical degradable hemostatic material

[0053] 1. Self-crosslinking: Weigh 5g of carboxymethyl chitosan and 20g of pregelatinized hydroxypropyl starch, mix evenly, and dry heat at 150°C for 3 hours to obtain a crosslinked sample.

[0054] 2. Preparation of microspheres: Dissolve the cross-linked sample in 800ml of water, stir and dissolve, and add the solution dropwise to 10% calcium chloride solidified solution by electrostatic droplet method, the voltage is 20kV, and the feeding rate is 300μL / min.

[0055] 3. Microsphere pore making: put the microsphere solution into an ultrasonic instrument for normal temperature ultrasonication, ultrasonic frequency 40kHz, power 1000W, ultrasonic 30min.

[0056] 4. Drying: The above-mentioned porous microspheres are dried by spray drying.

[0057] 5. Sterilization: The above samples are packaged and sterilized to obtain a medical degradable hemostatic material.

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Abstract

The invention provides a novel medical degradable hemostatic material and a preparation method thereof. According to the preparation method, a dry-heat crosslinking method is adopted to crosslink chitosan and a derivative thereof, and starch and a derivative thereof, a crosslinked sample is made into a microsphere by a method of electrostatic droplet, in the process of preparing the microsphere, asoluble calcium salt solution is used as stationary liquid, calcium ions are complexed on the microsphere, then physical pore-forming is conducted on the microsphere through a method of ultrasound, aporous microsphere sample is dried through supercritical and sprayed mode, the polysaccharide composite hemostatic material prepared by adopting the preparation method has the advantages of both thestarch and the chitosan, the hemostatic ability is high, antibacterial activity is achieved, toxicity and stimulation are avoided, the process is simple, reagent residue is avoided, pollution is avoided, the cost is low, using is convenient, the polysaccharide composite hemostatic material is suitable for fast hemostasis of massive bleeding, irregular parts and viscera, and also can be used as a raw material of anti-adhesion products, hemostasis products and dressing products.

Description

technical field [0001] The invention belongs to the field of medical dressings, and in particular relates to a novel medical degradable hemostatic material and a preparation method thereof. Background technique [0002] Blood loss is a common problem encountered in surgical operations, first aid for war injuries, daily accidents and natural disasters. If it cannot be effectively controlled in the first place, it may cause shock in the patient, and even endanger the life of the patient in severe cases. Therefore, the primary problem encountered in surgical operations, injury wounds and accidents is hemostasis. Hemostatic materials have the functions of stopping bleeding and promoting healing of wounds. The currently reported rapid hemostatic materials mainly include porous zeolite, plant starch, oxidized regenerated cellulose, collagen materials, and chitosan. [0003] Starch is a high polymer of glucose, which belongs to polysaccharides. It is abundant in natural resources,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00
CPCA61L24/001A61L24/0036A61L24/0042A61L24/02A61L24/08A61L2400/04C08L5/08C08L3/02
Inventor 朱翠兰石凌锋王国才陶秀梅陈鹏
Owner NKD PHARMA CO LTD
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