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Multifunctional mesoporous biological material, preparation method and application

A biomaterial, multi-functional technology, applied in the field of soft/hard tissue wound regeneration and repair, body surface, and emergency biomaterials in the body, it can solve the problems of adverse effects on patients' physiological functions, asynchronous evolution of inflammatory responses, and inability to effectively eradicate infections. Achieve the effect of inhibiting the activity of common pathogens on the wound, good histocompatibility, and promoting the apoptosis of pathogens

Pending Publication Date: 2021-10-19
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, how to organically coordinate various functions, solve various soft and hard tissue wound repair, and simultaneously prevent and control inflammation and infection is a thorny issue in the field of biomedical material preparation science
For example, soft and hard tissue injuries caused by various accidents have the problem of asynchronous evolution of inflammatory responses, especially the formation of biofilms caused by the accumulation of bacteria in hard tissues, so that the infection cannot be effectively eradicated. These are all issues that require close attention in tissue trauma repair. The use of inflammation and anti-infection drugs has adverse effects on the physiological functions of patients, and even causes drug resistance problems
These problems are all problems that traditional biomaterials and device products have not taken into account

Method used

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  • Multifunctional mesoporous biological material, preparation method and application
  • Multifunctional mesoporous biological material, preparation method and application
  • Multifunctional mesoporous biological material, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Example 1: SiO 2 -B 2 o 3 -CaO-P 2 o 5 -CuO-MgO-ZnO-SrO-Li 2 O-Na 2 O-K 2 O mesoporous material

[0085] 1) Add 0.02mol of P123 microstructure directing agent into 3000ml of deionized water at a ratio of 1:20, mechanically stir at 40°C for 4 hours to fully dissolve, adjust the pH value to 1.0 with hydrochloric acid solution, and continue stirring until the solution is clear ; Add 0.75mol tetraethyl orthosilicate to the above-mentioned acidic solution and fully hydrolyze it, add 0.06mol triethyl phosphate and hydrolyze it, followed by 0.57mol boric acid, 0.74mol calcium nitrate, 0.03mol copper nitrate, 0.01mol magnesium nitrate, 0.01 mol of zinc nitrate, 0.05mol of strontium nitrate, 0.01mol of lithium nitrate, 0.01mol of sodium nitrate, and 0.01mol of potassium nitrate were stirred at 40°C for 12 hours and at 95°C for 24 hours to obtain a sol solution;

[0086] 2) drying the sol solution obtained in step 1) at 120° C., and after fully drying, calcining at 700° C...

Embodiment 2

[0090] Example 2: SiO 2 -B 2 o 3 -CaO-P 2 o 5 -CuO-MgO-ZnO mesoporous materials

[0091] 1) Add 0.02mol of P123 microstructure directing agent into 3000ml of deionized water at a ratio of 1:30, mechanically stir at 40°C for 4 hours to fully dissolve, adjust the pH value to 2.0 with hydrochloric acid solution, and continue stirring until the solution is clear ; Add 0.89mol tetraethyl orthosilicate to the above-mentioned acidic solution and fully hydrolyze it, then add 0.04mol triethyl phosphate for hydrolysis, and successively add 0.23mol boric acid, 0.74mol calcium nitrate, 0.03mol copper nitrate, 0.01mol magnesium nitrate , 0.01mol zinc nitrate, stirred at 40°C for 12 hours, and stirred at 90°C for 24 hours to obtain a sol solution;

[0092] 2) Dry the sol solution obtained in step 1) at 120° C., and after fully drying, calcining at 650° C. for 6 hours to obtain a glassy mesoporous powder;

[0093] 3) Ball mill the powder obtained in step 2) for 5 hours, then add the ul...

Embodiment 3

[0096] Example 3: SiO 2 -B 2 o 3 -CaO-P 2 o 5 -CuO-ZnO mesoporous material

[0097] 1) Add 0.02mol of F127 microstructure directing agent into 2500ml of deionized water at a ratio of 1:25, mechanically stir at 40°C for 4 hours to fully dissolve, adjust the pH value to 1.5 with nitric acid solution, and continue stirring until the solution is clear ; Then add 0.89mol tetraethyl orthosilicate and 0.02mol triethyl phosphate to the above-mentioned acidic solution and fully hydrolyze, then add 0.19mol boric acid, 0.52mol calcium nitrate, 0.005mol copper nitrate, 0.02mol zinc nitrate, at 40 ℃ Stir for 12 hours, then stir at 90°C for 24 hours to obtain a sol solution;

[0098] 2) Dry the sol solution obtained in step 1) at 120°C, and after fully drying, calcining at 700°C for 8 hours to obtain a glassy mesoporous powder;

[0099] 3) Mill the powder obtained in step 2) for 3 hours, then add the ultrafine powder into 15% calcium chloride solution at a solid-to-liquid ratio of 1:2...

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Abstract

The invention discloses a multifunctional mesoporous biological material and a preparation method thereof. The amorphous glass state particulate matter is composed of an external wrapping mesoporous structure and an internal cabbage structure, the diameters of external wrapping annular mesopores are 5-25 nm, and the gap pitch of the internal cabbage structure is 30-200 nm. The main component of the mesoporous biological material is SiO2-B2O3-CaO, and the mesoporous biological material also contains P2O5, CuO, MgO, ZnO, SrO, Li2O, Na2O and / or K2O. A unique mesoporous particle material is prepared by using a microstructure directing agent and adopting a sol-gel method, and the preparation process is simple. The material is used for arterial and venous hemostasis and promoting healing or regenerative repair of soft tissue and bone tissue wounds, has good histocompatibility, and is a biomedical material capable of adjusting inflammatory response in wounds and preventing and treating pathogenic bacteria infection.

Description

technical field [0001] The invention relates to a multi-functional biological material with a unique porous structure, which is used for emergency wound hemostasis, antibacterial, soft tissue wound repair, and bone defect regeneration repair, and belongs to the field of body surface, internal soft / hard tissue wound regeneration repair, and first aid biomaterials. Background technique [0002] In our country, millions of people die every year due to excessive blood loss, tissue necrosis / infection, and bone defect nonunion and delayed healing etc. Especially in recent years, the aging of our country has accelerated, and various unhealthy living habits have become more and more prevalent, resulting in chronic inflammation, organ disease or injury, etc., which will cause various tissues and organs to be damaged or reconstructed after resection. Therefore, to achieve rapid hemostasis, inflammation control, infection prevention and control, and to promote the regeneration, repair...

Claims

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Application Information

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IPC IPC(8): C03C3/097C03C11/00A61L24/00A61L24/02A61L27/10A61L27/12A61L27/56
CPCC03C3/097C03C11/002A61L24/02A61L24/0036A61L27/10A61L27/12A61L27/56A61L2430/02A61L2430/10
Inventor 苟中入杨贤燕徐三中
Owner ZHEJIANG UNIV
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