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A corn stalk/chitin composite hemostatic sponge and its preparation method and application

A corn stalk and hemostatic sponge technology, applied in the application, pharmaceutical formulation, surgical adhesive and other directions, can solve the problems of poor hemostatic performance, insufficient flexibility, etc., and achieve the advantages of low cost, simple preparation method and easy operation, and reduction of secondary bleeding. effect of risk

Active Publication Date: 2021-09-21
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the lack of softness and poor hemostatic performance of the existing chitin sponge, the purpose of the present invention is to provide a corn stalk / chitin composite hemostatic sponge and its preparation method and application

Method used

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  • A corn stalk/chitin composite hemostatic sponge and its preparation method and application
  • A corn stalk/chitin composite hemostatic sponge and its preparation method and application
  • A corn stalk/chitin composite hemostatic sponge and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0046] A preparation method of a corn stalk / chitin composite hemostatic sponge, comprising the steps of:

[0047] (1) After washing and drying the whole component of corn stalks to remove impurities, they are pulverized into powder by a pulverizer to obtain corn stalk powder (particle size is 40-60 mesh), and then the corn stalk powder is processed under the action of mechanical external force of a ball mill. Ball milling (intermittent ball milling, pause for 5 minutes every 10 minutes, and the speed is 200r / min), the time of ball milling is 6 hours, and the corn stalk powder after ball milling is obtained;

[0048] (2) Perform ball milling on chitin under the mechanical external force of the ball mill (intermittent ball milling, stop for 5 minutes every 10 minutes, and the speed is 200r / min), and the time of ball milling is 6 hours to obtain chitin powder;

[0049] (3) Add the ball-milled corn stalk powder in step (1) into the sodium hydroxide / urea solvent, the mass ratio of ...

Embodiment 2

[0056] A preparation method of a corn stalk / chitin composite hemostatic sponge, comprising the steps of:

[0057] (1) After washing and drying the whole component of corn stalks to remove impurities, they are pulverized into powder by a pulverizer to obtain corn stalk powder (particle size is 40-60 mesh), and then the corn stalk powder is processed under the action of mechanical external force of a ball mill. Ball milling (intermittent ball milling, stop for 6 minutes every 12 minutes, and the speed is 205r / min), the time of ball milling is 7 hours, and the corn stalk powder after ball milling is obtained;

[0058] (2) Perform ball milling on chitin under the mechanical external force of the ball mill (intermittent ball milling, stop for 6 minutes every 12 minutes, and the speed is 205r / min), and the time of ball milling is 7 hours to obtain chitin powder;

[0059] (3) Add the ball-milled corn stalk powder in step (1) into the sodium hydroxide / urea solvent, the mass ratio of t...

Embodiment 3

[0066] A preparation method of a corn stalk / chitin composite hemostatic sponge, comprising the steps of:

[0067] (1) After washing and drying the whole component of corn stalks to remove impurities, they are pulverized into powder by a pulverizer to obtain corn stalk powder (particle size is 40-60 mesh), and then the corn stalk powder is processed under the action of mechanical external force of a ball mill. Ball milling (intermittent ball milling, stop for 7 minutes every 15 minutes, and the speed is 210 r / min), the time of ball milling is 8 hours, and the corn stalk powder after ball milling is obtained;

[0068] (2) Perform ball milling on chitin under the mechanical external force of the ball mill (intermittent ball milling, stop for 7 minutes every 15 minutes, and the speed is 210 r / min), and the milling time is 8 hours to obtain chitin powder;

[0069] (3) Add the ball-milled corn stalk powder in step (1) into the sodium hydroxide / urea solvent, the mass ratio of the bal...

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Abstract

The invention discloses a corn stalk / chitin composite hemostatic sponge, a preparation method and application thereof. The method comprises: respectively dissolving corn stalks and chitin in sodium hydroxide / urea solvent by multiple freezing and thawing methods, mixing the two after dissolving, adding epichlorohydrin for cross-linking reaction, standing at low temperature, After dialysis and drying, the corn stalk / chitin composite hemostatic sponge was obtained. The coagulation index of the composite sponge obtained by the invention is only 4.2±0.5%, compared with the coagulation factor of 48.5±0.4% of the medical PVF hemostatic sponge, the hemostatic performance of the composite sponge prepared by the invention is good. Since the raw materials of the composite sponge are green and recyclable biomass resources corn stalks and chitin, not only the agricultural, forestry and marine waste corn stalks and chitin are efficiently utilized, but also the prepared composite sponge is biodegradable and has good cell compatibility. The advantage is that it can avoid the risk of secondary bleeding caused by the removal of the hemostatic material during the application process.

Description

technical field [0001] The invention belongs to the field of functional materials, and in particular relates to a corn stalk / chitin composite hemostatic sponge and its preparation method and application. Background technique [0002] Rapid and efficient hemostasis is a key step in emergency medical treatment and is also the key to improving the survival rate of the injured. However, non-degradable hemostatic materials need to be removed by secondary surgery after use, and there is a risk of blood scab rupture and pulling injury, which is likely to cause secondary harm. Therefore, the research and development of fast, safe, efficient and degradable hemostatic materials is imperative. However, although absorbable and degradable hemostatic materials (commonly used hyaluronic acid gel, collagen sponge, etc.) have good biodegradability, the raw materials used have problems such as high cost and complicated purification process. Therefore, the use of low-cost, easy-to-prepare ra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/0036A61L24/0042A61L24/0073A61L2400/04C08L5/08
Inventor 王小英顾彬蒋启蒙
Owner SOUTH CHINA UNIV OF TECH
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