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Micro-porous starch composite styptic powder and preparation method thereof

A technology of microporous starch and hemostatic powder, which is applied in the fields of pharmaceutical formulations, surgical adhesives, applications, etc., can solve the problems of not being quickly absorbed by the human body, adverse reactions, and narrow application areas, and achieve good degradability, low cost, and The effect of easy operation

Inactive Publication Date: 2017-07-21
东莞博捷生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These hemostatic materials all have some obvious shortcomings, among which fibrin viscose, gelatin sponge, etc. have certain adverse reactions to the human body; zeolite and zeolite particles cannot be quickly absorbed by the human body; Narrow application

Method used

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  • Micro-porous starch composite styptic powder and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 300g of starch and dissolve in 400ml of sodium acetate buffer, weigh 3g of α-amylase and 1.5g of glucoamylase respectively and dissolve in 200ml of sodium acetate buffer; Under ~5 conditions, react for 24 hours to prepare a microporous starch solution with a mass volume ratio of 50%. Centrifuge the microporous starch solution at a speed of 3000r / min for 5min to collect the centrifugal precipitate; add 30ml of purified water to resuspend the precipitate, then centrifuge at a rotational speed of 3000r / min for 5min, repeat the resuspension 3 times, and collect the final centrifugal precipitate (microporous starch) . Dissolve the centrifugal precipitate (microporous starch) in 100ml of purified water, stir for 10 minutes, and vacuum filter to obtain a filter cake; redissolve the filter cake in 200ml of purified water, stir for 10 minutes, and vacuum again to obtain a filter cake. The filter cake was dried in a drying oven at 50°C for 6 hours. After drying, it was sie...

Embodiment 2

[0021] Weigh 270g starch and dissolve in 400ml sodium acetate buffer, weigh 2.7g α-amylase and 1.35g glucoamylase respectively and dissolve in 200ml sodium acetate buffer; Under the condition of pH 4~5, react for 24 hours to prepare a microporous starch solution with a mass volume ratio of 45%. Centrifuge the microporous starch solution at a speed of 3000r / min for 5min to collect the centrifugal precipitate; add 25ml of purified water to resuspend the precipitate, then centrifuge at a rotational speed of 3000r / min for 5min, repeat the resuspension 3 times, and collect the final centrifugal precipitate (microporous starch) . Dissolve the centrifugal precipitate (microporous starch) in 100ml of purified water, stir for 10 minutes, and vacuum filter to obtain a filter cake; redissolve the filter cake in 200ml of purified water, stir for 10 minutes, and vacuum again to obtain a filter cake. The filter cake was dried in a drying oven at 50°C for 6 hours. After drying, it was sieve...

Embodiment 3

[0023] Weigh 330g starch and dissolve in 400ml sodium acetate buffer, weigh 3.3g α-amylase and 1.65g glucoamylase respectively and dissolve in 200ml sodium acetate buffer; Under the condition of pH 4~5, react for 24 hours to prepare a microporous starch solution with a mass volume ratio of 55%. Centrifuge the microporous starch solution at a speed of 3000r / min for 5min to collect the centrifugal precipitate; add 35ml of purified water to resuspend the precipitate, then centrifuge at a rotational speed of 3000r / min for 5min, repeat the resuspension 3 times, and collect the final centrifugal precipitate (microporous starch) . Dissolve the centrifugal precipitate (microporous starch) in 100ml of purified water, stir for 10 minutes, and vacuum filter to obtain a filter cake; redissolve the filter cake in 200ml of purified water, stir for 10 minutes, and vacuum again to obtain a filter cake. The filter cake was dried in a drying oven at 50°C for 6 hours. After drying, it was sieve...

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Abstract

The invention provides micro-porous starch composite styptic powder and a preparation method thereof. The preparation method includes hydrolyzing alpha-amylase and glucoamylase prior to washing, drying and sieving to obtain micro-porous starch, and sufficiently mixing and granulating, by weight, 50-90 parts of micro-porous starch and 10-50 parts of sodium carboxymethyl starch so as to obtain the micro-porous starch composite styptic powder. The micro-porous starch composite styptic powder prepared by the preparation method is efficient in styptic function, can be adhered to the wound surface to form hydrogel on the wound surface and promote healing of the wound surface and has excellent biocompatibility and biodegradability.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a microporous starch composite hemostatic powder and a preparation method thereof. Background technique [0002] Blood is one of the basic substances that constitute the human body and maintain human life activities. Traumatic bleeding is a frequent occurrence in human life. When the amount of traumatic bleeding reaches 20% of the total blood volume of the human body, obvious shock symptoms will appear; when it reaches 40% of the total blood volume of the human body, there will be life-threatening. Rapid and effective hemostasis is an important guarantee for the safety of patients' lives. For a long time, traditional methods of hemostasis such as ligation, suture, electrocoagulation, absorbable hemostatic clips and tourniquets not only increase the difficulty of surgery for medical workers, but also affect the surgical field of vision and cause hidden dangers of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/08A61L24/001A61L24/0036A61L24/0042A61L2400/04
Inventor 徐安龙梁东杨顶建吴赟荆琛峰张广献
Owner 东莞博捷生物科技有限公司
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