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Cornstalk/chitin compound hemostatic sponge and preparation method and application thereof

A corn stalk and hemostatic sponge technology, which is applied in the application, pharmaceutical formulation, surgical adhesive and other directions, can solve the problems of insufficient softness, poor hemostatic performance, etc., and achieves the effects of simple and easy operation, low cost and good degradability of the preparation method.

Active Publication Date: 2019-11-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the lack of softness and poor hemostatic performance of the existing chitin sponge, the purpose of the present invention is to provide a corn stalk / chitin composite hemostatic sponge and its preparation method and application

Method used

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  • Cornstalk/chitin compound hemostatic sponge and preparation method and application thereof
  • Cornstalk/chitin compound hemostatic sponge and preparation method and application thereof
  • Cornstalk/chitin compound hemostatic sponge and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A preparation method of a corn stalk / chitin composite hemostatic sponge, comprising the steps of:

[0047] (1) After washing and drying the whole component of corn stalks to remove impurities, they are pulverized into powder by a pulverizer to obtain corn stalk powder (particle size is 40-60 mesh), and then the corn stalk powder is processed under the action of mechanical external force of a ball mill. Ball milling (intermittent ball milling, pause for 5 minutes every 10 minutes, and the speed is 200r / min), the time of ball milling is 6 hours, and the corn stalk powder after ball milling is obtained;

[0048] (2) Perform ball milling on chitin under the mechanical external force of the ball mill (intermittent ball milling, stop for 5 minutes every 10 minutes, and the speed is 200r / min), and the time of ball milling is 6 hours to obtain chitin powder;

[0049] (3) Add the ball-milled corn stalk powder in step (1) into the sodium hydroxide / urea solvent, the mass ratio of ...

Embodiment 2

[0056] A preparation method of a corn stalk / chitin composite hemostatic sponge, comprising the steps of:

[0057] (1) After washing and drying the whole component of corn stalks to remove impurities, they are pulverized into powder by a pulverizer to obtain corn stalk powder (particle size is 40-60 mesh), and then the corn stalk powder is processed under the action of mechanical external force of a ball mill. Ball milling (intermittent ball milling, stop for 6 minutes every 12 minutes, and the speed is 205r / min), the time of ball milling is 7 hours, and the corn stalk powder after ball milling is obtained;

[0058] (2) Perform ball milling on chitin under the mechanical external force of the ball mill (intermittent ball milling, stop for 6 minutes every 12 minutes, and the speed is 205r / min), and the time of ball milling is 7 hours to obtain chitin powder;

[0059] (3) Add the ball-milled corn stalk powder in step (1) into the sodium hydroxide / urea solvent, the mass ratio of t...

Embodiment 3

[0066] A preparation method of a corn stalk / chitin composite hemostatic sponge, comprising the steps of:

[0067] (1) After washing and drying the whole component of corn stalks to remove impurities, they are pulverized into powder by a pulverizer to obtain corn stalk powder (particle size is 40-60 mesh), and then the corn stalk powder is processed under the action of mechanical external force of a ball mill. Ball milling (intermittent ball milling, stop for 7 minutes every 15 minutes, and the speed is 210 r / min), the time of ball milling is 8 hours, and the corn stalk powder after ball milling is obtained;

[0068] (2) Perform ball milling on chitin under the mechanical external force of the ball mill (intermittent ball milling, stop for 7 minutes every 15 minutes, and the speed is 210 r / min), and the time of ball milling is 8 hours to obtain chitin powder;

[0069] (3) Add the ball-milled corn stalk powder in step (1) into the sodium hydroxide / urea solvent, the mass ratio of...

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Abstract

The invention discloses cornstalk / chitin compound hemostatic sponge and a preparation method and application thereof. The preparation method comprises the steps that cornstalk and chitin are correspondingly dissolved in sodium hydroxide / urea solvents by adopting a method of multiple-time freezing and thawing, the cornstalk and the chitin are mixed after dissolving, epichlorohydrin is added for a cross-linking reaction, still standing is conducted at the low temperature, drying is conducted after dialysis, and the cornstalk / chitin compound hemostatic sponge is obtained. According to the cornstalk / chitin compound hemostatic sponge, the clotting index is only 4.2+ / -0.5%, compared with medical PVF hemostatic sponge with 48.5+ / -0.4% of blood coagulation factor, the hemostatic performance of theprepared compound sponge is good. Due to the fact that the raw materials of the compound sponge are green recyclable biomass resources of the cornstalk and the chitin, the agricultural and forestry marine wastes of the cornstalk and the chitin are efficiently utilized, the prepared compound sponge further has the advantages of biodegradation and good cytocompatibility, and the risk of secondary bleeding caused by removing of hemostatic materials in the application process can be avoided.

Description

technical field [0001] The invention belongs to the field of functional materials, and in particular relates to a corn stalk / chitin composite hemostatic sponge and its preparation method and application. Background technique [0002] Rapid and efficient hemostasis is a key step in emergency medical treatment and is also the key to improving the survival rate of the injured. However, non-degradable hemostatic materials need to be removed by secondary surgery after use, and there is a risk of blood scab rupture and pulling injury, which is likely to cause secondary harm. Therefore, the research and development of fast, safe, efficient and degradable hemostatic materials is imperative. However, although absorbable and degradable hemostatic materials (commonly used hyaluronic acid gel, collagen sponge, etc.) have good biodegradability, the raw materials used have problems such as high cost and complicated purification process. Therefore, the use of low-cost, easy-to-prepare ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/0036A61L24/0042A61L24/0073A61L2400/04C08L5/08
Inventor 王小英顾彬蒋启蒙
Owner SOUTH CHINA UNIV OF TECH
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