Polysaccharide composite film for arresting bleeding and preparation method thereof

A technology of polysaccharide compounding and chitosan film, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of side effects caused by patients, high molecular weight of natural polymers, slow absorption speed, etc., and achieve thorough and efficient hemostasis Effect

Inactive Publication Date: 2012-07-18
张晓金
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the hemostatic materials widely used clinically include gelatin sponge and cellulose series, etc. These hemostatic materials have their shortcomings: Gelatin sponge: its raw material source is animal, has certain antigenicity and allergenicity, and absorbs slowly , may lead to complications; cellulose series: because cellulose lacks cellulase in the human body to degrade it, and the natural polymer has a large molecular weight, it also takes a long time to degrade after use, which may bring side effects to patients
In short, hemostasis is a complex process of physiological changes, such as physical hemostasis, chemical hemostasis, and physiological hemostasis. For different bleeding methods, corresponding hemostatic methods should be selected. Traditional single materials may not be optimal in the hemostasis process. The hemostatic effect of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] First, take 75 parts by weight of a neutral aqueous solution, place it in a container, keep a constant temperature of 60°C in a water bath, stir mechanically, add 5 parts by weight of nano-chitosan, stir for 30 minutes, and vacuum filter the obtained The filtrate is chitosan solution.

[0031] Then, take 300 parts by weight of a neutral aqueous solution, put it in a container, and keep a constant temperature of 80 ° C by means of a water bath, mechanically stir, add 10 parts by weight of pregelatinized starch, stir for 30 minutes, and press filter the obtained filtrate for the starch solution.

[0032] Finally, the above-mentioned chitosan solution is placed in a mold, freeze-dried and solidified to form a chitosan film; add the above-mentioned starch solution on the chitosan film, send it to an oven for drying, and solidify and form after all the water evaporates. A polysaccharide composite film for hemostasis was obtained by molding.

[0033] In the polysaccharide c...

Embodiment 2

[0035] First, take 10 parts by weight of a neutral aqueous solution, place it in a container, and keep it at a constant temperature of 10°C by means of a water bath, stir it mechanically, add 0.5 parts by weight of carboxymethyl chitosan, stir for 10 minutes, and vacuum Filtrate gained filtrate is chitosan solution.

[0036] Then, take 100 parts by weight of a neutral aqueous solution, place it in a container, keep a constant temperature of 10°C in a water bath, stir mechanically, add 5 parts by weight of carboxymethyl starch, stir for 10 minutes, press filter the obtained filtrate for the starch solution.

[0037] Finally, the above-mentioned chitosan solution is placed in a mold, and naturally cast and dried to form a chitosan film; the above-mentioned starch solution is added on the top of the chitosan film, and sent to an oven for drying. After all the water evaporates, it is solidified and formed. The polysaccharide composite film used for hemostasis was obtained by demoul...

Embodiment 3

[0040] First, take 100 parts by weight of a neutral aqueous solution, place it in a container, keep a constant temperature of 60°C in a water bath, stir mechanically, add 50 parts by weight of hydroxyethyl chitosan, stir for 35 minutes, press filter The resulting filtrate is chitosan solution.

[0041] Then, take 1000 parts by weight of a neutral aqueous solution, put it in a container, and keep a constant temperature of 80°C by means of a water bath, stir mechanically, add 100 parts by weight of hydroxyethyl starch, stir for 35 minutes, and vacuum filter the obtained The filtrate is starch solution.

[0042] Finally, put the above-mentioned chitosan solution in a mold, bake and dry in an oven to form a chitosan film; add the above-mentioned starch solution on top of the chitosan film, and cast it naturally until all the water evaporates, then solidify and form, and demould A polysaccharide composite film for hemostasis was obtained.

[0043] In the polysaccharide composite ...

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PUM

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Abstract

The invention discloses a polysaccharide composite film for arresting bleeding, which comprises a starch film and a chitosan film, wherein the starch film and the chitosan film form mutually bonded structures through drying after the starch film in a liquid state permeates through the chitosan film in a solid state; and the mass ratio of the starch film and the chitosan film is 0.1-1 to 50-1. The invention further discloses a preparation method of the polysaccharide composite film for arresting bleeding. The preparation method comprises the following steps: preparing chitosan solution; preparing starch solution; placing the chitosan solution into a die for solidification and formation so as to obtain a chitosan film; and adding starch solution on the chitosan film and forming through solidification, so as to obtain the polysaccharide composite film for arresting bleeding. In the invention, when the composite film is used for arresting bleeding, various mechanisms for arresting bleeding can be started at the same time, so as to enable bleeding arresting to be more efficient and safe; besides, the composite film material of the invention can be degradable and absorbable, and also can play effective wound protecting and anti-adhesion effects at the same.

Description

technical field [0001] The invention relates to a biomedical composite film and a preparation method thereof, in particular to a polysaccharide composite film for hemostasis and a preparation method thereof, belonging to the field of biomedical material production. Background technique [0002] Hemostasis is a common and important clinical process, because excessive blood loss can lead to life-threatening, so research on reliable and efficient hemostatic materials has attracted much attention. Especially in various complex surgical operations, reducing bleeding and shortening operation time have an important impact on the success or failure of the operation and the health of the patient after recovery. With the continuous improvement of the performance requirements of hemostatic materials in the medical field, it is imperative to develop materials with better hemostatic effect. A hemostatic dressing or hemostatic agent with superior performance needs to have good hemostatic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42
Inventor 张晓金
Owner 张晓金
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