Polysaccharide composite film for arresting bleeding and preparation method thereof

Abstract

The invention discloses a polysaccharide composite film for arresting bleeding, which comprises a starch film and a chitosan film, wherein the starch film and the chitosan film form mutually bonded structures through drying after the starch film in a liquid state permeates through the chitosan film in a solid state; and the mass ratio of the starch film and the chitosan film is 0.1-1 to 50-1. The invention further discloses a preparation method of the polysaccharide composite film for arresting bleeding. The preparation method comprises the following steps: preparing chitosan solution; preparing starch solution; placing the chitosan solution into a die for solidification and formation so as to obtain a chitosan film; and adding starch solution on the chitosan film and forming through solidification, so as to obtain the polysaccharide composite film for arresting bleeding. In the invention, when the composite film is used for arresting bleeding, various mechanisms for arresting bleeding can be started at the same time, so as to enable bleeding arresting to be more efficient and safe; besides, the composite film material of the invention can be degradable and absorbable, and also can play effective wound protecting and anti-adhesion effects at the same.

Description

technical field [0001] The invention relates to a biomedical composite film and a preparation method thereof, in particular to a polysaccharide composite film for hemostasis and a preparation method thereof, belonging to the field of biomedical material production. Background technique [0002] Hemostasis is a common and important clinical process, because excessive blood loss can lead to life-threatening, so research on reliable and efficient hemostatic materials has attracted much attention. Especially in various complex surgical operations, reducing bleeding and shortening operation time have an important impact on the success or failure of the operation and the health of the patient after recovery. With the continuous improvement of the performance requirements of hemostatic materials in the medical field, it is imperative to develop materials with better hemostatic effect. A hemostatic dressing or hemostatic agent with superior performance needs to have good hemostatic...

AI Technical Summary

Problems solved by technology

[0003] At present, the hemostatic materials widely used clinically include gelatin sponge and cellulose series, etc. These hemostatic materials have their shortcomings: Gelatin sponge: its raw material source is animal, has certain antigenicity and allergenicity, and absorbs slowly , may lead to complications; cellulose series: because cellulose lacks cellulase in the human body to degrade it, and the natural polymer has a large molecular weight, it also takes a long time to degrade after use, which may bring side effects to patients

In short, hemostasis is a complex process of physiological changes, such as physical hemostasis, chemical hemostasis, and physiological hemostasis. For different bleeding methods, corresponding hemostatic methods should be selected. Traditional single materials may not be optimal in the hemostasis process. The hemostatic effect of