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Porous hydrogel sponge as well as preparation method and application thereof

A porous hydrogel and sponge technology, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of unfavorable material biocompatibility, high hemostatic performance, unsatisfactory hemostatic effect of dry hydrogels, lack of uniform pore structure and pore size and other issues, to achieve excellent biocompatibility and degradation performance, improve water absorption and hemostatic efficiency, and mild pore-making conditions.

Pending Publication Date: 2021-12-21
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally, when wet hydrogel is used as a hemostatic material, hemostasis is performed through physical blocking, and most wet hydrogels have low hemostatic efficiency due to defects such as poor bonding performance and poor mechanical properties; Hydrogel's hemostatic effect is not ideal
[0004] At present, the common methods for preparing bioporous hydrogels mainly include salt leaching method, phase separation method, freeze-drying method, gas foaming method, etc., but these methods often lack uniform and interconnected pore structure and pore size, or the preparation In the process, additional chemicals need to be introduced to increase toxicity, which is not conducive to the biocompatibility of the material and the rapid and efficient hemostasis performance

Method used

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  • Porous hydrogel sponge as well as preparation method and application thereof
  • Porous hydrogel sponge as well as preparation method and application thereof
  • Porous hydrogel sponge as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] This embodiment has prepared a kind of porous hydrogel sponge, and specific process is:

[0047] S1: Take 0.3 g of gelatin microspheres with a particle size of about 100 μm and place them in a polytetrafluoroethylene mold, and gently tap the mold to make the gelatin microspheres tightly packed and the surface smooth;

[0048] S2: Inject ethanol solution into the stacked gelatin microspheres, inject about 1 mL of ethanol solution with a volume concentration of 80% per gram of gelatin microspheres;

[0049] S3: Move the mold to an oven at 70°C for 8 minutes;

[0050] S4: taking out the mold and freeze-drying to obtain a template of gelatin microspheres bonded to each other, and the microspheres adjacent to each other are slightly bonded at the interface to form a template of gelatin microspheres bonded to each other;

[0051]S5: Put the gelatin microsphere template in step S4 into 1 mL of 2% double-bonded hyaluronic acid containing 0.2% 2-hydroxyl-4'-(2-hydroxyethoxyl)-2...

Embodiment 2

[0056] This embodiment has prepared a kind of porous hydrogel sponge, and specific process is:

[0057] S1: Take 0.3 g of gelatin microspheres with a particle size of about 230 μm and place them in a polytetrafluoroethylene mold, and gently tap the mold to make the gelatin microspheres tightly packed and the surface smooth;

[0058] S2: Inject ethanol solution into the stacked gelatin microspheres, inject about 1 mL of ethanol solution with a volume concentration of 80% per gram of gelatin microspheres;

[0059] S3: Move the mold to an oven at 70°C for 8 minutes;

[0060] S4: taking out the mold and freeze-drying to obtain gelatin microsphere templates bonded to each other, and the microspheres adjacent to each other are slightly bonded at the interface to form gelatin microsphere templates bonded to each other;

[0061] S5: Put the gelatin microsphere template in step S4 into 1 mL of 2% double-bonded hyaluronic acid containing 0.2% 2-hydroxyl-4'-(2-hydroxyethoxyl)-2-methylpr...

Embodiment 3

[0066] This embodiment has prepared a kind of porous hydrogel sponge, and specific process is:

[0067] S1: Take 0.3 g of gelatin microspheres with a particle size of about 300 μm and place them in a polytetrafluoroethylene mold, and gently tap the mold to make the gelatin microspheres tightly packed and the surface smooth;

[0068] S2: Inject ethanol solution into the stacked gelatin microspheres, inject about 1 mL of ethanol solution with a volume concentration of 80% per gram of gelatin microspheres;

[0069] S3: Move the mold to an oven at 70°C for 8 minutes;

[0070] S4: taking out the mold and freeze-drying to obtain gelatin microsphere templates bonded to each other, and the microspheres adjacent to each other are slightly bonded at the interface to form gelatin microsphere templates bonded to each other;

[0071] S5: Put the gelatin microsphere template in step (4) into 1 mL of 2% double bond containing 0.2% 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone In the...

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Abstract

The invention provides porous hydrogel sponge as well as preparation and application thereof. According to the porous hydrogel sponge, the pore structure is controllable, uniform and mutually communicated, the porosity and the specific surface area in the hydrogel sponge are effectively increased, and the water absorption and the hemostasis efficiency of the porous hydrogel sponge are improved. The porous hydrogel sponge is prepared by freeze-drying the porous hydrogel, and the preparation method is simple. The porous hydrogel sponge disclosed by the invention has excellent biocompatibility and degradability, and can be used for quickly and efficiently stopping bleeding of various wounds.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a porous hydrogel sponge and its preparation method and application. Background technique [0002] Hemostasis is a key link in trauma treatment. Effective hemostasis is the key measure to reduce casualties. In order to avoid death caused by excessive blood loss, relevant researchers strive to develop hemostatic materials with excellent effects. Traditional hemostatic materials and products mainly include hemostatic gauze, bandages, and hemostatic sponges. Clinical applications have found that such products have poor hemostatic effects, are not degradable in the body, and are difficult to be absorbed by the body, so the scope of use is limited. How to develop new, degradable and easily absorbable hemostatic gauze or sponge has become a research hotspot. [0003] The new porous hydrogel material has a specific network cross-linked structure, has functional charac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/26C08J3/24C08J3/075C08L5/08C08L89/00A61L15/28A61L15/32A61L15/42
CPCC08J9/26C08J3/246C08J3/075A61L15/425A61L15/42A61L15/32A61L15/28A61L2400/04C08J2201/0424C08J2305/08C08J2389/00C08L89/00C08L5/08
Inventor 国翠平黄骏鲁道欢于珊
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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