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Application of icaritin in preparation of medicine for preventing and treating gastrointestinal hemorrhage

A technology for gastrointestinal bleeding and icariin, which is applied in the field of medicine

Pending Publication Date: 2021-09-10
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no literature report on the use of icarigenin in the treatment of gastrointestinal bleeding

Method used

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  • Application of icaritin in preparation of medicine for preventing and treating gastrointestinal hemorrhage
  • Application of icaritin in preparation of medicine for preventing and treating gastrointestinal hemorrhage
  • Application of icaritin in preparation of medicine for preventing and treating gastrointestinal hemorrhage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation Example 1 Icarigenin Tablets

[0031]

[0032] Preparation process: mix icariin with auxiliary materials microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make soft material, and pass through a 16-mesh sieve to granulate. The wet granules are dried at 60°C, the dry granules are passed through a 20-mesh sieve for granulation, the fine powder in the dry granules is screened out, mixed with magnesium stearate, and then mixed with the dry granules, pressed into tablets, each tablet is about 200mg, that is, .

Embodiment 2

[0033] Preparation Example 2 Icarigenin Capsule Preparation

[0034]

[0035]

[0036] Preparation process: 100g of icariin, 120g of lactose and 130g of corn starch are mixed in a mixer for 10-15 minutes, 5g of magnesium stearate is added and mixed for 1-3 minutes, and then filled into 1000 capsule shells.

Embodiment 3

[0037] Preparation Example 3 Icarigenin Microemulsion Preparation

[0038]

[0039] Preparation process: Weigh the prescription amount of soybean oil, polyoxyethylene-23-lauryl ether, and 1,2-propylene glycol, mix and stir evenly, then add icarigenin to dissolve, and ultrasonic treatment can also be used to speed up the dissolution and obtain clarification The solution is the icarigenin microemulsion preparation. The particle size was measured by a laser particle size analyzer, and the average particle size was 15nm.

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Abstract

The invention belongs to the field of medicines, and relates to medical application of icaritin, in particular to application of icaritin in preparation of medicines for preventing and treating gastrointestinal hemorrhage. According to the invention, icaritin is respectively researched on gastrointestinal hemorrhage caused by peptic ulcer, gastrointestinal ulcer hemorrhage caused by medicines and gastrointestinal hemorrhage caused by tumor chemoradiotherapy. Research results show that icaritin has an obvious effect of reducing an incidence rate of gastrointestinal hemorrhage caused by various reasons, has an exact curative effect and an obvious effect on gastrointestinal hemorrhage, and is expected to become an efficient and rapid gastrointestinal hemorrhage prevention and treatment medicine.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the medical use of icariin, in particular to the use of icariin in the preparation of medicines for preventing and treating gastrointestinal bleeding. Background technique [0002] The gastrointestinal tract includes the upper gastrointestinal tract, middle gastrointestinal tract, and lower gastrointestinal tract. Among them, upper gastrointestinal bleeding is a medical emergency, which can be caused by factors such as gastric mucosal injury and upper gastrointestinal ulcer. Peptic ulcer (PU) is one of the common diseases in gastroenterology, which refers to chronic ulcers that occur in the stomach and duodenum. PU accompanied by acute upper gastrointestinal hemorrhage (uppergastrointestinal haemorrhage, UGIH) has the characteristics of rapid disease progression and acute onset. In addition, many drugs such as non-steroidal anti-inflammatory drugs, thrombolytics, antithrombotic drugs, and v...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P1/00A61P7/04
CPCA61K31/352A61P1/00A61P7/04
Inventor 张贵民李斌王升兰
Owner LUNAN PHARMA GROUP CORPORATION
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