15 results about "Peptic ulceration" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a bifunctional compound with anti-helicobacter pylori and acid inhibition activity, a preparation method of the bifunctional compound and application of the bifunctional compound in preparation of medicines for treating peptic ulcer and helicobacter pylori infection. According to the compound, a potassium ion competitive acid blocker vonoprazan is used as an acid inhibition unit, and rifobetine is used as an anti-helicobacter pylori unit; the two compounds are respectively subjected to covalent modification through linking groups Linker 1 and Linker 2, and then are connected by virtue of a triazole ring to form a series of bifunctional compounds shown as a general formula (I). The compound can simultaneously and synergistically act on two key targets of gastric acid secretion and helicobacter pylori, so that not only is the treatment effect remarkably enhanced, but also better safety is shown due to the fact that the same curative effect can be achieved at a lower dosage.

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine preparation for treating peptic ulcer and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following components in parts by weight: 10 to 15 parts of cassia twig, 10 to 20 parts of radix paeoniae alba, 10 to 20 parts of radix salviae miltiorrhizae, 8 to 12 parts of rhizoma cyperi, 4 to 8 parts of rhizoma chuanxiong, 25 to 35 parts of rhizoma corydalis, 10 to 20 parts of herba artemisiae scopariae, 25 to 35 parts of cortex magnoliae officinalis, 8 to 12 parts of caulis perillae and 2 to 4 parts of liquorice root. According to the invention, theories of dialectical treatment, holism concept and the like are reasonably applied, the compatibility is scientific and reasonable, the prescription is simplified, the preparation process is simple, the efficacy is accurate, the clinical applicability is strong, and the efficacy on peptic ulcer is exact. The traditional Chinese medicine preparation is an innovation of medicines for treating peptic ulcer, and has remarkable economic and social benefits.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating peptic ulcer and a preparation method and application thereof. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of sun-dried ginseng, 9-15 parts of roasted rhizoma atractylodis macrocephalae, 9-15 parts of white poria, 3-9 parts of honey-fried licorice root, 9-15 parts of rhizoma pinelliae preparata, 10-20 parts of cuttlebone, 6-12 parts of fructus amomi, 6-12 parts of rhizoma coptidis and 9-15 parts of pericarpium citri reticulatae. Starting from the theory of syndrome differentiation and treatment of traditional Chinese medicine, the traditional Chinese medicine preparation has the functions of tonifying qi and spleen and resolving dampness and descending adverse-rising energy, has a remarkable treatment effect on peptic ulcer, is convenient to take and is easily accepted by patients.

The present invention provides a tegoprazan sugar acid salt and a preparation method therefor, the salt being pharmaceutically usable for gastroesophageal disease, gastroesophageal reflux disease, gastritis, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcer, non-erosive reflux disease (NERD) and the like. The tegoprazan sugar acid salt of the present invention has excellent water solubility and stability of tegoprazan, and thus can be particularly useful as a pharmaceutical injection preparation.

The present invention discloses a pharmaceutical composition for preventing or treating drug-related peptic ulcers, comprising zastaprazan or a pharmaceutically acceptable salt thereof.

The application relates to the medical technical field, in particular to application of zidovudine in preparation of a medicine for preventing and / or treating alcoholic gastric ulcer, and experiment results show that the zidovudine has a remarkable curative effect on peptic ulcer disease and inflammatory bowel disease, can effectively improve mucosal integrity, promote tissue morphology improvement, and restore animal body weight, and has a good clinical application prospect.

The present invention relates to the field of medical technology, and more particularly to the use of gemcitabine hydrochloride in the preparation of a medicament for preventing and / or treating alcoholic gastric ulcers. Experimental results show that the gemcitabine hydrochloride has significant therapeutic effects on peptic ulcer disease and inflammatory bowel disease, can effectively improve mucosal integrity, promote tissue morphology improvement, and restore animal weight, and has good clinical application prospects.

Disclosed herein are new salts and polymorphs of cethromycin for the treatment of diseases due to infection by bacteria and certain protozoans, including, for example, malaria, Babesosis, Toxoplasmosis, diarrheal disease, respiratory disease, sexually transmitted bacterial infections, and some bioterror bacteria, including, for example, plague, tularemia and post-inhalation anthrax. Also disclosed herein are new salts and polymorphs of cethromycin for the treatment of inflammatory diseases, including, for example, pelvic inflammatory disease, and peptic ulcer disease.

The invention discloses an artificial intelligence assisted peptic ulcer combined hemorrhage endoscopic risk assessment network and model, the assessment network is a classification network, the classification network comprises more than one double-branch module, the double-branch module divides an input feature into two branches to be processed respectively, and the two branches are connected with each other. One branch extracts local features of the image through convolution operation, the other branch extracts global spatial features of the image through depth separation convolution, different normalization methods are adopted for the two branches, the convolution branch adopts batch normalization operation, and the depth separation convolution branch adopts layer normalization operation; a compression-incentive attention module is embedded in the output end of each branch, so that the classification network can adaptively enhance respective important feature channels in the two branches, and then channel splicing is performed to fuse the features of the double branches. The classification network can well perform peptic ulcer combined bleeding endoscopic image feature extraction.

The present invention relates to an OMV vaccine that can prevent Helicobacter pylori infection and a preparation method thereof. The vaccine uses a conserved trisaccharide (Trio) in Helicobacter pylori lipopolysaccharide as a core antigen epitope, and its structure is α-DD-Hep-(1→3)-α-D-Fuc-(1→3)-β-D-GlcNAc-. The epitope is biosynthesized by recombinant Escherichia coli, and a non-reducing end of a core oligosaccharide on the Escherichia coli outer membrane vesicle (OMV) is used as a connection anchor. The oligosaccharide is catalyzed and synthesized by glycosyltransferases from Helicobacter pylori and Escherichia coli. Trio can be efficiently displayed on the surface of OMV using this oligosaccharide on the surface of bacteria. Animal experiments have shown that the vaccine has the ability to activate the body's immune response and protective efficacy, and can be developed as a vaccine to prevent Helicobacter pylori infection. It has important application value and significance for effectively preventing and treating diseases such as peptic ulcers, chronic inflammation, and even gastric cancer caused by Helicobacter pylori infection.

The application relates to the medical technical field, in particular to application of 6-mercapto guanine in preparation of a medicine for preventing and / or treating alcoholic gastric ulcer, experimental results show that the 6-mercapto guanine has remarkable curative effect on peptic ulcer disease and inflammatory bowel disease, can effectively improve mucosal integrity, promote tissue morphology improvement, restore animal body weight, and has a good clinical application prospect.

The invention provides a pharmaceutical composition for treating peptic ulcer as well as pills and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following raw materials: 120 to 160 parts of fructus chebulae, 120 to 160 parts of gypsum rubrum powder, 20 to 30 parts of false chinese swertia herb, 25 to 36 parts of travertine, 20 to 25 parts of fructus amomi rotundus, 4 to 8 parts of oxytropis falcate bunge, 60 to 70 parts of Zhaxun cream, 150 to 170 parts of pterocephalus hookeri, 10 to 15 parts of pawpaw, 20 to 28 parts of safflower, 20 to 30 parts of nutmeg, 2 to 6 parts of benzoin, 45 to 56 parts of radix inulae, 18 to 24 parts of agilawood, 20 to 30 parts of pomegranate seed, 20 to 30 parts of clove, 20 to 30 parts of fructus tsaoko, 30 to 40 parts of usnea longissima, 30 to 40 Through reasonable raw material compatibility, the traditional Chinese medicine composition has the effects of strengthening the spleen and stomach, regulating qi and relieving pain, clearing heat and relieving acid, astringing to stop bleeding and promoting tissue regeneration and healing ulcer, and can regulate and control expression of inflammatory cytokines such as TNF-alpha and IL-6 and relieve inflammatory response of peptic ulcer, so that gastric mucosa is protected, healing of gastric ulcer can be promoted, and the curative effect is good. Therefore, an excellent effect of treating the peptic ulcer is achieved.

The invention relates to a novel skeleton compound containing cyclic carbamate and application. The novel compounds (I-1 and II-1) provided by the invention are compounds with novel structures. A biological activity experiment shows that the compound has muscarinic acetylcholine receptor M1 antagonistic activity and can be applied to preparation of drugs for peptic ulcer, irritable bowel syndrome or mental diseases and the like related to muscarinic acetylcholine receptors.

Disclosed in the present invention is a pharmaceutical composition for the prevention or treatment of drug-related peptic ulcer, comprising zastaprazan or a pharmaceutically acceptable salt thereof.