113 results about "Peptic ulceration" patented technology

The invention relates to an oral medicinal composition formulation for treating peptic ulcer. The composition comprises esomeprazole, antiacid sodium bicarbonate and a medicinally acceptable carrier, wherein the esomeprazole contains an acid-sensitive proton pump inhibitor; and the antiacid sodium bicarbonate can improve the stability of the proton pump inhibitor. The invention also relates to a preparation method of the medicinal composition. Two active ingredients are integrated into one fixed unit formulation, so that response is quick, a medicinal scheme is simplified in the process of treating the peptic ulcer, and the compliance of a patient is improved.

The invention discloses a rhodiola rosea compound composition for treating peptic ulcer. The rhodiola rosea compound composition is a preparation prepared from the following active pharmaceutical ingredients in parts by weight: 4.2-7.2 parts of rhodiola rosea, 14-26 parts of poria cocos, 10.5-19.5 parts of dandelion, 10.5-19.5 parts of capillary artemisia, 10.5-19.5 parts of white atractylodes rhizome, 7-13 parts of pogostemon cablin, 7-13 parts of raw malt, and 3.5-6.5 parts of fructus amomi rotundus. The compound composition disclosed by the invention is exact in compatibility of medicines, quite less in medical ingredients, not only capable of ensuring medicine efficacy and reducing side effects, but also capable of effectively treating gastric ulcer, duodenal ulcer, and erosive gastritis, and provides a new administration choice for the clinical treatment of the peptic ulcer.

The invention discloses a pharmaceutical preparation used for treating erosive reflux oesophagitis, a gastroesophageal reflux disease, maintaining a long-term therapy to prevent the recurrence of oesophagitis for a cured patient, controlling the symptoms of gastroesophageal reflux diseases, eradicating helicobacter pylori jointly medicated with an appropriate antimicrobial therapy, healing duodenal ulcer related to helicobacter pylori infections and preventing the recurrence of peptic ulcer related to helicobacter pylori, and particularly relates to a prepared sustained-release oral formulation adopting esomeprazole magnesium as the ingredient. The pharmaceutical preparation aims to supplement the deficiency of the prior art and provide a sustained-release esomeprazole magnesium dropping pill. The sustained-release esomeprazole magnesium dropping pill overcomes the defects in the prior art effectively, guarantees no occurrence of an obvious quality change for the drug during the effective storage period and has the advantages of controllable release time, full release and high bioavailability simultaneously.

The invention discloses a medicine composition containing tea polyphenol and alginic acid or salts thereof and application thereof. The polyphenol and alginic acid or salts thereof contained in the invention are capable of being prepared into various types of pharmaceutic preparations which comprising tablets, capsulas, granules, pills, oral solution, injection and the like. The medicine composite can be used for preparing medicines for treating and preventing peptic ulcer.

The invention relates to a method for extracting and purifying Pinostrobin from medicinal plants, and a pharmaceutical preparation and application thereof. The invention particularly discloses a method for extracting and purifying Pinostrobin from medicinal plants, and a pharmaceutical preparation and application thereof in preparing medicines for treating gastroenteropathy, and belongs to the field of life sciences. The method comprises the following steps: extracting medicinal plants with 70-95% ethanol homogenate; and after the extract is concentrated to a certain volume, standing to precipitate, removing a supernatant, dissolving the obtained precipitate with an organic solvent, separating by gel-resin column chromatography, crystallizing and recrystallizing to obtain the Pinostrobin monomer of which the purity is higher than 90%. The Pinostrobin monomer in which different excipients can be added is prepared into any common pharmaceutical formulation. The pharmaceutical preparation has obvious biological activity on peptic ulcer, gastritis, stomachache, gastric evacuation (gasterectasis), alimentary tract tumors and the like caused by Helicobacter pylori infection, and has thecharacteristic of no toxic or side effect.

The invention belongs to the technical field of drugs, and relates to a compound tablet for treating peptic ulcer and a method for preparing the same. In the compound tablet, an anti acid agent (an H2 receptor blocking agent and a proton pump inhibitor) and an united synergic agent of an antibiotic or two types of antibiotics or disunited synergic agent are used as a tablet core. The tablet core comprises main materials and auxiliary materials, wherein the main materials consist of an anti acid agent, a stomach mucous membrane protective agent and one or two types of antibacterial agents; the dosage range of the anti acid agent is between 10 and 40mg, and the cyclodextrin is adopted for coating or self emulsification; the dosage range of each type of antibacterial drug is between 100 and 1,000mg; and the dosage range of the stomach mucous membrane protective agent is between 100 and 500mg. By adopting the reaction of the anti acid agent and the cyclodextrin to prepare a coating matter or for self emulsification, the anti acid agent is treated, and the treated anti acid agent, antibacterial drugs and proper amount of auxiliary materials are pressed into the tablet core, and the tablet core is externally coated with an enteric coating or pressed into the enteric coating. The compound tablet and the method have the advantages of obviously improving the stability and the bioavailability of the anti acid agent and the antibiotics, and simultaneously effectively lowering the irritation of certain antibiotics on stomach.

Disclosed are methods for the prevention or treatment of a disease or infection caused by or associated with H. Pylori in a subject infected by H. Pylori, the method comprising orally administering a halogenated salicylanilide such as niclosamide to the subject. The method may be used for the prevention or treatment of, for example dyspepsia, gastritis, peptic ulcer disease, premalignant gastric lesions, gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma.

The invention discloses a preparation method of a medicine for treating peptic ulcers. The method comprises the following steps: (1) weighing raw medicinal materials in parts by weight: 17 to 23 parts of potentilla anserina, 7 to 12 parts of poria cocos, 5 to 9 parts of oriental wormwood, 5 to 9 parts of pogostemon cablin, 5 to 9 parts of raw malt, 3 to 7 parts of mangnolia officinalis, 3 to 7 parts of perilla leaves and 3 to 7 parts of caulis perllae; (2) pulverizing the potentilla anserina to form powder for later use; firstly adding 55-95v / v% (volume per volume) ethyl alcohol into the other medicinal materials except for the potentilla anserina for extracting, filtering to obtain an alcohol extract for later use, decocting filter residue by adding water, combining the alcohol extract with the filter residue, concentrating and then adding the potentilla anserina powder and pharmaceutically acceptable auxiliary materials so as to obtain the medicine. The medicine is less in medicinal flavor according to a specific dosage proportion, and can be used for effectively treating gastric ulcers, duodenal ulcers and erosive gastritis, thereby providing a new medicine selection for clinic treatment of the peptic ulcers. Meanwhile, the pharmacological test proves that the pharmacological activity of the medicine is improved in manners of double alcohol-water extraction and pulverization of the potentilla anserina into medicinal powder, so that the economical utilization of medicinal material resources is realized.

A Chinese medicine for treating peptic ulcer is prepared from 13 Chinese-medicinal materials including Mantis egg-case, bletilla tube, Sichuan chinaberry, corydalis tuber, etc. Its advantages are high curative effect, quickly taking its effect, low recurrence rate, and no untoward effect.

The invention relates to new functions and applications of trametes lactinea(Berk.)Pat. or extractives and trametenloic acid B. The substance trametes lactinea(Berk.)Pat has the functions of digestive gastric ulcer resistance, and nonulcerative-indigestion resistance through increasing of gastric motility. The trametes lactinea(Berk.)Pat. or the extractives and the trametenloic acid B have certain inbibitional effects on cell proliferation of gastric cancer cells, esophagus cancer cells Eca-109 and colorectal cancer cells LOVO, and has a wide range of research value and mass production and edible value in dugs for digestive system and gastric cancer resisting and the like.

The invention discloses a bacterial strain as well as a composition and application, and relates to the technical field of strain separation and application. The Cristinia sp. provided by the invention can be applied to treatment or prevention of liver function impairment and liver function impairment related diseases, alimentary canal mucosal injury and alimentary canal mucosal injury related diseases, diabetes, obesity and obesity related diseases. The inventor verifies that the Cristinia sp. provided by the invention has no toxic or side effect on the kidney and can reduce the weight of the liver; the initial steatohepatitis focus can be treated; fat accumulation of liver cells can be slowed down; AST and ALT in serum can be reduced; and abdominal white fat inflammatory lesion can be reduced. The Cristinia sp. can also repair the digestive tract mucosa, recover the barrier function of the mucosa, and prevent and treat intestinal leakage, peptic ulcer and other diseases caused by barrier function impairment. The Cristinia sp. also has the effects of reducing fasting blood-glucose of a body, regulating insulin level and reducing body fat of mammals, and has the effects of preventing and treating diabetes and improving the metabolic function of obese patients.

The invention discloses a capsule for remedying peptic ulcer and a preparation method thereof. The capsule takes Chinese medicinal plants of astragalus, white peony root, angelica, cassia twig, cuttlebone, fritillary bulb, siphonostegia chinensis, coptis chinensis, liquorices and so on as raw materials. The cuttlebone is crushed. The volatile oil is extracted from angelica, cassia twig and siphonostegia chinensis. The volatile oil is packed by beta-cylodextrin. The astragalus is extracted by water. The white peony root, fritillary bulb, coptis chinensis and liquorices are extracted by alcohol. The extracting solutions is made into fine power after being condensed and processed by spray drying. The capsule is made by publicly known capsule technology and the weight of each capsule is 0.3g. The capsule has efficacy of nourishing the essential Qi, warning the stomach, inhibiting acid, stopping pain, activating blood, remedying ulcer and preventing recurrence. The capsule mainly cures peptic ulcer of deficiency cold of spleen and stomach type, and the symptoms of the disease are that the stomach is pain and is indulging in warm and press or pains at night with pantothenic acid and vomiting bitter.

The invention discloses a process for preparing Chinese medicinal powder for treating peptic ulcer. The process is characterized by comprising the following steps of: 1, performing further process optimization on the fineness of cuttlebone, officinal magnolia bark and a finished product to form the superfine powder, namely powder with a particle size of over 150 meshes; and 2, studying and improving an extraction process of hippophae rhamnoides, namely extracting fat soluble ingredients alone, and extracting water-soluble active ingredients from medicinal dregs and liquoric root, largehead atractylodes rhizome and phellodendron which contain the water-soluble active ingredients again, so that active ingredients in the hippophae rhamnoides are retained completely. When the process is used,the active ingredients and active positions can be extracted fully, and surplus ineffective impurities are removed; the problems of large medicinal dose and high content of impurities are solved, andthe trouble of moisture absorption of products during storage and transportation is eliminated, so the Chinese medicinal powder is safe, effective and controllable in quality, and the waste of raw materials is prevented.

The invention discloses a traditional Chinese medicine preparation for treating peptic ulcer and a preparation method thereof. The traditional Chinese medicine preparation disclosed by the invention is prepared from the following medicinal materials in parts by weight: 30-47 parts of radix angelicae, 21-29 parts of resina draconis, 22-31 parts of cuttlebone, 13-26 parts of liquorice, 10-21 parts of trichosanthes peel, 13-25 parts of fructus evodiae, 18-29 parts of endothelium corneum gigeriae galli, 20-36 parts of rhizoma corydalis, 10-18 parts of cinnamon, 25-39 parts of corydalis tuber, 2-7 parts of frankincense, 9-18 parts of myrrh, 3-12 parts of clove, 5-17 parts of fructus piperis longi, 6-18 parts of concha arcae, 15-27 parts of dandelion, 11-24 parts of homalomena occulta, 6-17 parts of teasel root, 8-17 parts of rhizoma cyperi, 3-8 parts of nard, 13-24 parts of curcuma aromatica, 6-14 parts of curcuma zedoary, 1-9 parts of rhizoma acori graminei, 3-12 parts of rhizoma atractylodis, and 8-17 parts of gynostemma pentaphylla. The traditional Chinese medicine preparation disclosed by the invention is a pure traditional Chinese medicine prescription and has the advantages of being low in toxic and side effects, good in curative effect and short in treatment course; for treating peptic ulcer, the traditional Chinese medicine preparation is high in curative ratio; furthermore, the traditional Chinese medicine preparation is wide in medicine source and low in cost; and thus, the traditional Chinese medicine preparation is applied to being clinically popularized and applied.

The invention discloses a traditional Chinese medicine for treating peptic ulcer and a preparation method thereof. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 24-39 parts of astragalus root, 21-28 parts of Zhejiang fritillary bulb, 19-31 parts of dried ginger, 11-20 parts of amomum fruit, 13-24 parts of tetradium ruticarpum, 20-38 parts of magnolia bark, 18-27 parts of glycyrrhiza uralensis, 16-29 parts of wolfberry, 11-23 parts of bupleurum root, 15-28 parts of radix paeoniae alba, 1-7 parts of costus root, 9-18 parts of cortex dictamni, 2-9 parts of salvia miltiorrhiza, 11-18 parts of poria cocos, 2-8 parts of angelica sinensis, 3-8 parts of chorion ovi, 3-7 parts of radix curcumae, 5-13 parts of natural indigo, 6-19 parts of borneol, 5-13 parts of pomegranate bark, 9-18 parts of prepared ovate atractylodes, 2-8 parts of rhubarb root, 3-7 parts of coptis root, 1-6 parts of panax pseudo-ginseng, 2-7 parts of pinellia tuber, 3-8 parts of dried tangerine peel and 1-7 parts of citrus aurantium. The traditional Chinese medicine is a pure Chinese traditional medicine prescription, and is low in toxic or side effects, good in treatment effect, short in treatment course and high in cure rate during the treatment of peptic ulcer; the source of the medicinal materials is wide, and the cost is low, so that the traditional Chinese medicine is applicable to clinical popularization and application.

The present invention discloses a Chinese and Western medicine mixture preparation for curing indegestion of non-ulcerative, gastritis and peptic gastric ulcer-Weibingkang and its preparation method.Its prescription contains dahurian angelica root 40-60g, bighead atractylodes rhizome 40-80g, kalimeris indica 100-180 g, wild chrysanthemum plant 60-240g and furoxone 4-12g. Its preparation method includes: preparing bighead atractylodes rhizome into stir-fried one or bran-frield one or scorch-fried one for stand-by, preparing dahurian angelica root, kalimeris indica and wild chrysanthemum plantaccording to conventional method, placing the prepared Chinese medicinal materials in a container, adding water, decocting for several times, taking supernatant fluid, mixing for several times, concentrating to 400-1500 ml, preservation and mixing.

The invention relates to composite active lyophilized powder and a preparation method and application thereof. The preparation method comprises the steps of washing raw materials, crushing, extracting, carrying out centrifugal separation, concentrating with a reverse osmosis concentrator, collecting concentrate, and lyophilizing the concentrate to obtain the composite active lyophilized powder, wherein the raw materials at least include one of fresh Rosa roxbunghii fruit and fresh blueberry. During extraction, the weight ratio of the raw materials to water is 1:(3-5). The preparation method ofthe composite active lyophilized powder is simple, has low energy consumption, enables a solvent to be recycled, is free of wastewater emission during production, and allows active ingredients to bepreserved completely; the composite active lyophilized powder prepared via the preparation method has the significant effects of treating oral ulcers, treating gastric ulcers and treating other pepticulcers, is applicable to the development of drugs and health-care foods and has good commercial prospect and medical prospect.

The invention discloses a Chinese medicinal combination for curing digestive ulcer and the application thereof, prepared mainly of cortex dictamni radicis, Greater Celandine Herb, Nardostachys Root, Bletilla tuber, and Rhizoma Corydalis as main raw materials. And its preparing method includes the following steps of: weighing the raw materials according to the formula; extracting naphtha from cortex dictamni radicis, and Nardostachys Root; refluxing the dregs and Greater Celandine Herb, etc, by alcohol and extractig twice, two hours each time, placing still, filtering, recovering alcohol from the filtrate, and concentrating into extract; uniformly the extract, naphtha, proper amounts of tartaric acid, citric acid and sodium bicarbonate and stirring continuously, and taking out them after wetted, softened and conglobated, and making them into granules of proper size, and drying the granules at 50-60 deg.C. It can clear heat and detoxify, and tonify spleen and stimulate the appetite as well as kill or prohibit helicobacter pylori. And it has characters of short period of treatment, no dependence, obvious curative effect, high cure rate, strong relativity to cure digestive ulcer, and wide acting range.

The present invention provides medicine composition for preventing and treating peptic ulcer. The medicine composition has active components prepared with dandelion 15-60 wt%, tuckahoe 15-60 wt%, bletilla tuber 15-60 wt% and notoginseng 5-50 wt%. It has the functions of invigorating spleen, tranquilizing, promoting diuresis, astringing to stop bleeding, etc. The medicine composition of the present invention is used in treating peptic ulcer and may be also used as stomach invigorating health product for taking regularly.

A benzimidazole derivative of formula (1): (wherein R represents a hydrogen atom or a methoxy group, and n is 0 or 1) or a salt thereof; and a medicament containing the same.The compounds of the present invention, due to minimized difference in therapeutic effect between subjects, which difference would otherwise be derived from different CYP2C19 activity from subject to subject, ensure that all patients can enjoy proper therapeutic effects at the same dose of the drug. Also, the compounds of the invention have low risk of drug interaction caused by induction of CYP1A family member enzymes, as well as low risk of development of cancer, and thus is useful as a remedy for peptic ulcer, reliably providing therapeutic effects with safety.

The present invention provides a method for creating rat acetic acid gastric ulcer recurrence model. Said method includes the following steps: creating rat acetic acid gastric ulcer and ulcer natural healing model, and using aspirin to induce the naturally-heated ulcer to be recurred, measuring the change of physiological and biochemical indexes in the process of rat ulcer recurrence so as to confirm that the recurrence model of gastric ulcer is created. Said model not only can be used in the research of clinical peptic ulcer recurrence mechanism, but also can be used for screening the medicines for clinically curing peptic ulcer and medicines for resisting ulcer recurrence.

The invention discloses a Chinese patent medicine for treating peptic ulcer and a preparation method thereof. The Chinese patent medicine mainly comprises radix astragali, pseudo-ginseng, red ginseng, pearl layer powder, and artificial bezoar, and is prepared by steps of extract preparation, separation concentration, ultramicro-crushing of the pearl layer powder, dry paste preparation, and preparation formation. When compared with medicine prepared by original process, the medicine prepared by the method of the invention has decreased dosage and improved medicine curative effect.

The invention discloses a preparation method of a medicine for treating peptic ulcer. The preparation method comprises the following operating steps: (1) weighing the following raw materials in parts by weight: 7-13 parts of bighead atractylodes rhizome, 7-13 parts of poria cocos, 7-13 parts of seed of vigna umbellata, 5-10 parts of radix astragali, 5-10 parts of herba artemisiae scopariae, 5-10 parts of dandelion, 3-7 parts of bitter apricot seed, 3-7 parts of radix platycodi, 3-7 parts of stem or leaf of pogostemon cablin, 2-3 parts of dried ginger and 2-3 parts of ginseng; and (2) adding water with the weight 8-15 times that of the raw materials into the raw materials for decocting and extracting for three times, wherein the extraction for the first time lasts for 10-20min and the extraction for the second time and the extraction for the third time respectively last for 30-60min, and combining decoctions so as to obtain the medicine for treating peptic ulcer. The medicine disclosed by the invention, on the basis of a synergistic effect among the medicinal raw materials which are subjected to reasonable combination, is effective on treating gastric ulcer, duodenal ulcer and erosive gastritis; therefore, a new choice is provided for clinical medication of treating the peptic ulcer. The preparation method disclosed by the invention, by virtue of a water-decocting process, can be used for simply and safely preparing a medicine or an extract which is concrete in efficacy on treating peptic ulcer; and the preparation method is conductive to saving production cost and is convenient for industrial production.

The invention discloses a fibronectin (FN) oral agent for preventing and curing gastric and intestinal ulcers. The FN oral agent is characterized by comprising the following components in percentage by weight: 0.05-0.20% of FN, 0.01-0.15% of active small molecule peptide, 1-5% of lysyme, 10-20% of sweetening agent and the balance of water. The FN oral agent disclosed by the invention takes the bioactive ingredient, namely FN, as a core functional component assisted by the active small molecule peptide, lysyme, xylitol and the like, so that the FN oral agent can effectively promote proliferation of mucous epithelium and cells, can participate in cell metabolism and activate the cells, and not only can effectively cure peptic ulcers including gastric ulcer, duodenal ulcer and the like, but also can achieve effects of resisting aging, maintaining beauty, improving immunity and the like.

The invention provides a compound comprising a proton pump inhibitor and a gastric mucosa protective agent and an application of the compound. The compound comprises the proton pump inhibitor and the gastric mucosa protective agent and can be directly mixed or indirectly connected through hydrogen bonds, co-crystallized sodium hydrate formed by hydrogen bond connection is more stable in property, and pharmacokinetic property is remarkably improved. Although the proton pump inhibitor and the gastric mucosa protective agent are different in action mechanism, the compound formed by the proton pump inhibitor and the gastric mucosa protective agent has unexpected synergistic effects and has a positive application prospect in the field of digestive ulcer and gastrointestinal bleeding treatment.

The invention belongs to the technical field of medicines and discloses a pharmaceutical compound for treating peptic ulcer and a preparation method thereof. The invention in particular discloses a vonoprazan fumarate-hydrate and a preparation method thereof. The vonoprazan fumarate-hydrate is high in purity and good in stability, and has characteristic diffraction peaks at 3.21 degrees, 5.62 degrees, 6.53 degrees, 9.12 degrees, 14.43 degrees, 15.53 degrees, 18.61 degrees, 21.72 degrees, 24.61 degrees and 27.71 degrees in an X-ray powder diffraction pattern represented by 2theta+0.2 degrees. The X-ray powder diffraction pattern measured by using a Cu-Kalpha ray is as shown in a formula 1. Different with the prior art, through experiments, the solubleness of the vonoprazan fumarate-hydrate obtained by the invention is remarkably improved surprisingly. The invention also discloses the preparation method of the vonoprazan fumarate-hydrate. The preparation method is simple and easy to operate, mild in reaction condition and suitable for large-scaled production. A composition troche prepared from the vonoprazan fumarate-hydrate provided by the invention is remarkably improved in dissolution rate and stability, and is quite suitable for clinical application.

The invention provides a solid dispersion for treating peptic ulcers. The solid dispersion is prepared from raw medicine powder and polyethylene glycol-6000 which are matched in the proportion of 1-3:1-3 w / w. The raw medicine powder is prepared by smashing raw medicine to 300-500 meshes, wherein the raw medicine is prepared from, by weight, 7-13 parts of rhizoma atractylodis macrocephalae, 7-13 parts of poria cocos, 7-13 parts of phaseolus calcaratus, 5-10 parts of astragalus membranaceus, 5-10 parts of capillary artemisia, 5-10 parts of dandelion, 3-7 parts of semen armeniacae amarae, 3-7 parts of platycodon grandiflorum, 3-7 parts of platycodon grandiflorum, 2-3 parts of dried ginger and 2-3 parts of ginseng. The solid dispersion is prepared from raw medicine powder, the bioavailability of medicine is improved, and anti-ulcer activity is improved remarkably.

The invention discloses a tablet for treating peptic ulcer; the tablet is prepared by tabletting 100 parts by weight of granules and 1-5 parts by weight of a lubricant, wherein the granules consist of the following raw materials: 7-13 parts of bighead atractylodes rhizome, 7-13 parts of poria cocos, 7-13 parts of seed of vigna umbellata, 5-10 parts of radix astragali, 5-10 parts of herba artemisiae scopariae, 5-10 parts of dandelion, 3-7 parts of bitter apricot seed, 3-7 parts of radix platycodi, 3-7 parts of stem or leaf of pogostemon cablin, 2-3 parts of dried ginger and 2-3 parts of ginseng. The medicine, which is prepared from a few of medicinal materials on the basis of a special dosage ratio, is effective on treating gastric ulcer, duodenal ulcer and erosive gastritis; therefore, a new choice is provided for clinical medication of treating the peptic ulcer. Meanwhile, through a pharmacodynamic test, the preparation method disclosed by the invention, by virtue of double-extracting through alcohol and water and medicating ginseng in the form of powder, can effectively improve pharmacodynamic activity; and the preparation method is beneficial for conservation and utilization of medicinal resources.

The invention relates to cholinolytic drug glycopyrronium bromide and a composition, in particular to a pharmaceutical drug and a preparation thereof. The drug contains a compound with the formula shown in the specification and an enantiomer of the compound. Serving as an anticholinergic drug, the drug and the preparation can be clinically applied to anesthesia, peptic ulcers, salivation and the like. The bulk drug or the preparation has the effects of restraining gastric secretion and regulating gastrointestinal peristalsis, has a stronger salivation resisting effect than atropine, but has no central anticholinergic activity. Generally, the drug or the preparation is clinically applied to gastric and duodenal ulcers, chronic gastritis, excessive gastric acid secretion and the like.