Polyaldehyde dextran/montmorillonite composite rapid hemostatic material and preparation method thereof
A technology of aldehyde dextran and hemostatic materials, which can be applied in medical formulations, surgical adhesives, applications, etc., can solve the problem of poor hemostatic effect, achieve good hemostatic effect, convenient application, and good biocompatibility
Active Publication Date: 2018-06-05
DALIAN UNIV OF TECH
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Problems solved by technology
Although the military kaolin product "CombatGauze" has solved the exothermic and peripheral embolism problems of the previous two generations of products (QuickClot and WoundStat), kaolin hemostatic materials are only suitable for light and moderate bleeding, and the hemostatic effect is far inferior to WoundStat
Method used
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Experimental program
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Effect test
Embodiment 1
[0023] A 20% aqueous solution was prepared by mixing aldehyde dextran with a molecular weight of 20kDa and montmorillonite at a mass ratio of 5:1, adding it to a custom-made abrasive tool, and freeze-drying for 6 hours to obtain a spongy hemostatic material (PM1). The scanning electron microscope image is as follows figure 1 shown.
Embodiment 2
[0025] Aldehydedextran with a molecular weight of 40kDa and montmorillonite were formulated into a 15% aqueous solution at a mass ratio of 10:1, added to a custom-made abrasive tool, and freeze-dried for 12 hours to obtain a spongy hemostatic material (PM2).
Embodiment 3
[0027] Aldehydedextran with a molecular weight of 90kDa and montmorillonite were formulated into a 5% aqueous solution at a mass ratio of 50:1, added to a custom-made abrasive tool, and freeze-dried for 18 hours to obtain a spongy hemostatic material (PM3).
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Abstract
The invention discloses a preparation method of a polyaldehyde dextran / montmorillonite composite rapid hemostatic material. The polyaldehyde dextran / montmorillonite composite rapid hemostatic materialis prepared by taking polyaldehyde dextran and montmorillonite, which have different molecular weights, as raw materials to prepare a mixed solution, and then freezing and drying. The polyaldehyde dextran / montmorillonite composite rapid hemostatic material obtained by the preparation method provided by the invention is characterized in that blood can be rapidly concentrated on wound parts and blood cells are gathered; meanwhile, a blood coagulation system is rapidly activated so that more efficient and rapid hemostasis of the hemostatic material is realized. The material can be prepared intobandage type dressing, adhesive bandages and self-sticking dressing and operation kits and the like, and can be used for carrying out a physical adsorption effect through other antibacterial, wound-healing-promoting and pain-stopping medicines; the hemostatic material is used as a novel medicine delivery carrier and realizes multifunction integration of the hemostatic material.
Description
technical field [0001] The invention relates to a compound rapid hemostatic material based on aldehyde dextran / montmorillonite and a preparation method thereof, belonging to the technical field of biomedical hemostatic materials. Background technique [0002] Uncontrolled bleeding is considered the leading cause of most deaths, with pre-hospital bleeding accounting for approximately one-third of all deaths in emergency settings. The direct cause of the death of the injured in an accident is not the accident itself, but excessive blood loss. Even if the wounded can be sent to the hospital for emergency treatment, a large amount of blood loss before the hospital will still cause a high mortality rate and serious complications (such as amputation) , nerve tissue necrosis, etc.). Therefore, new materials and methods to control uncontrolled bleeding are urgently needed. [0003] So far, there are very few emergency life-saving hemostatic materials used in the domestic market fo...
Claims
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Patent Timeline
Login to view more IPC IPC(8): A61L24/02A61L24/08
CPCA61L24/02A61L24/08A61L2400/04C08L5/02
Inventor 乔卫红柳春玉郑策
Owner DALIAN UNIV OF TECH
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