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Self-adaptive degradable hemostatic material and preparation method thereof

A hemostatic material and self-adaptive technology, applied in the field of medicine, can solve problems such as wound tearing, neglect, and blood clot damage

Active Publication Date: 2021-03-19
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, these hemostasis-focused inventions ignore a key problem
After successful hemostasis, the removal of the hemostatic material will often lead to the problem of blood clot damage or wound tearing, causing secondary damage to the injured; moreover, the wound site itself has an inflammatory reaction, and clay-based hemostatic materials often promote inflammation. Generate a lot of ROS
Because the controllable inflammatory response is beneficial to wound healing, but excessive ROS inhibits wound repair and causes other diseases

Method used

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  • Self-adaptive degradable hemostatic material and preparation method thereof
  • Self-adaptive degradable hemostatic material and preparation method thereof
  • Self-adaptive degradable hemostatic material and preparation method thereof

Examples

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preparation example Construction

[0051] The present invention provides a method for preparing an adaptive degradable hemostatic material described in the above technical solution, comprising the following steps:

[0052] The silane coupling agent is reacted with diatomite to obtain modified diatomite;

[0053] dissolving the cell active oxygen responsive polymer and the drug, mixing with the modified diatomite, and ultrasonicating to obtain a drug-loaded and ROS-responsive polymer grafted modified diatomite;

[0054] The biomacromolecule is dissolved in water and compounded with the drug-loaded and ROS-responsive polymer-grafted modified diatomite to obtain an adaptive degradable hemostatic material.

[0055] The method provided by the invention is simple and easy to implement, has no pollution, can be prepared in large quantities, and has high commercial value.

[0056] The invention reacts the silane coupling agent with the diatomite to obtain the modified diatomite. The silane coupling agent and diatomit...

Embodiment 1

[0069] The preparation method of adaptive biodegradable hemostatic gel is as follows:

[0070] Disperse diatomite and APTES in ethanol at a mass ratio of 1:3, reflux and stir at 80°C for 12 hours, and wash with ethanol several times to obtain modified diatomite.

[0071] A 6% acetic acid solution was prepared by dissolving double-terminal aldehyde modified polyaryl oxalate in acetic acid; aspirin was dissolved in 10 wt% ethanol solution to prepare a saturated solution. Mix the acetic acid solution of polyaryl oxalate and the saturated aspirin solution at a mass ratio of 1:1 to obtain a mixed solution, mix the modified diatomaceous earth with the mixed solution at a mass ratio of 1:50, and sonicate for 1 h. Centrifuge at 10000rpm for 30min to obtain drug-loaded modified diatomite.

[0072] Dissolve chondroitin sulfate and sodium alginate in ultrapure water at a mass ratio of 1:1 to prepare a 2% solution of chondroitin sulfate and sodium alginate; the mass ratio of chondroitin ...

Embodiment 2

[0074] The preparation method of adaptive biodegradable hemostatic gel is as follows:

[0075] Diatomite and GPTMS were dispersed in ethanol at a mass ratio of 1:3, refluxed and stirred at 80°C for 12 hours, and washed with ethanol several times to obtain modified diatomite.

[0076]The double-terminal amino-modified phenylboronate-based polycarbonate was dissolved in acetic acid to prepare a 6% acetic acid solution; the indomethacin was dissolved in 10 wt% ethanol solution to prepare a saturated solution. Mix the acetic acid solution of phenylboronate-based polycarbonate and the saturated indomethacin solution at a mass ratio of 1:1 to obtain a mixed solution, mix the modified diatomaceous earth with the mixed solution at a mass ratio of 1:50, and sonicate for 1 h. Centrifuge at 10000rpm for 30min to obtain drug-loaded modified diatomite.

[0077] Chondroitin sulfate and hyaluronic acid are dissolved in ultrapure water according to the mass ratio of 1:1 to prepare 2% chondro...

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Abstract

The invention provides a self-adaptive degradable hemostatic material and a preparation method thereof. The self-adaptive degradable hemostatic material is prepared from modified diatomite, a cell active oxygen responsive polymer, biomacromolecules and a drug material, wherein the biomacromolecules are selected from one or more of sodium alginate, chitosan, chondroitin sulfate and hyaluronic acid;and the modified diatomite is prepared by reaction of a silane coupling agent and diatomite. The modified diatomite adsorbs the drug through capillarity, electrostatic interaction and hydrogen bonds,and fixes the ROS responsive polymer through a chemical reaction, so that the drug loaded in the modified diatomite is released when the ROS level rises due to a disease reaction during material degradation or at a wound; therefore, the self-adaptive degradable hemostatic material is endowed with drug loading and releasing capabilities; and removing is not needed, the anti-inflammatory wound healing promoting effect continues to be achieved, and automatic degradation is achieved along with the wound healing material.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an adaptive degradable hemostatic material and a preparation method thereof. Background technique [0002] Wars and accidents often bring huge casualties, a large part of which comes from the failure to effectively control bleeding. According to statistics, many injured died due to excessive blood loss on the way to the hospital. Therefore, the research progress of hemostatic materials has received much attention. Generally speaking, hemostasis is a stress response for self-protection after the biological body itself is damaged. It is realized through a series of coagulation cascade reactions, including activation of platelets to form thrombus, activation of thrombin pathway, activation of fibrinogen to form fibrin network, etc. Common hemostatic materials on the market often focus on promoting blood coagulation by absorbing flowing blood, enriching blood cells, ac...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/04A61L24/02A61L24/00
CPCA61L24/001A61L24/0015A61L24/0031A61L24/0036A61L24/0042A61L24/02A61L24/046A61L24/08A61L2300/21A61L2300/41A61L2400/04C08L67/00C08L69/00C08L5/08C08L5/04
Inventor 石强杨鹤马志方关兴华刘静川
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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