Medical dressing for hemostasis and preparation method thereof

A medical polyglutamic acid technology, applied in the field of hemostatic medical dressings and its preparation, can solve the problems of not being able to keep the wound moist, delay wound healing, and damage granulation tissue, so as to promote rapid coagulation, wound healing, and tissue repair Effect

Inactive Publication Date: 2018-09-21
INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional dressings also have obvious disadvantages, such as not keeping the wound moist and delaying wound healing; wound granulation tissue is easy to grow into the mesh of the dressing, and it is easy to adhere to the wound when the dressing is changed, damaging the new granulation tissue and causing pain; the dressing penetrates Poor posterior barrier effect, easy to cause exogenous infection, poor hemostatic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A hemostatic medical dressing is prepared from the following raw materials in parts by weight: 50 parts of polyglutamic acid-pullulan polysaccharide cross-linked polymer, 25 parts of oat protein, 20 parts of cod skin collagen peptide, basophilic hyaline cutin 15 parts of granules, 15 parts of glycolic acid, 8 parts of garlic polysaccharide, and 10 parts of sodium hyaluronate.

[0027] The polyglutamic acid-pullulan polysaccharide cross-linked polymer is prepared by the following method: adding the pullulan polysaccharide solution to the polyglutamic acid solution, stirring and reacting at 30°C for 1h, anhydrous Precipitate the mixed solution with ethanol, collect the precipitate by vacuum filtration, dissolve the precipitate with deionized water, place it in a dialysis bag for dialysis for 1 hour, and freeze-dry the dialysis retentate to obtain a polyglutamic acid-pullulan cross-linked polymer.

[0028] Said, the mass ratio of polyglutamic acid solution and pullulan sol...

Embodiment 2

[0038] A hemostatic medical dressing is prepared from the following raw materials in parts by weight: 50 parts of polyglutamic acid-pullulan polysaccharide cross-linked polymer, 20 parts of oat protein, 25 parts of cod skin collagen peptide, basophilic hyaline cutin 10 parts of granules, 20 parts of glycolic acid, 5 parts of garlic polysaccharide, 15 parts of sodium hyaluronate.

[0039] The polyglutamic acid-pullulan polysaccharide cross-linked polymer is prepared by the following method: adding the pullulan polysaccharide solution to the polyglutamic acid solution, stirring and reacting for 1 hour at 25°C, and anhydrous Precipitate the mixed solution with ethanol, collect the precipitate by vacuum filtration, dissolve the precipitate with deionized water, place it in a dialysis bag for dialysis for 1.5 hours, and freeze-dry the dialysis retentate to obtain a polyglutamic acid-pullulan cross-linked polymer.

[0040] Said, the mass ratio of polyglutamic acid solution and pullu...

Embodiment 3

[0050]A hemostatic medical dressing is prepared from the following raw materials in parts by weight: 50 parts of polyglutamic acid-pullulan polysaccharide cross-linked polymer, 30 parts of oat protein, 15 parts of cod skin collagen peptide, basophilic hyaline cutin 20 parts of granules, 10 parts of glycolic acid, 10 parts of garlic polysaccharide, 5 parts of sodium hyaluronate.

[0051] The polyglutamic acid-pullulan polysaccharide cross-linked polymer is prepared by the following method: adding the pullulan polysaccharide solution to the polyglutamic acid solution, stirring and reacting at 35°C for 1h, anhydrous Precipitate the mixed solution with ethanol, collect the precipitate by vacuum filtration, dissolve the precipitate with deionized water, place it in a dialysis bag for dialysis for 0.5 h, and freeze-dry the dialysis retentate to obtain a polyglutamic acid-pullulan cross-linked polymer.

[0052] Said, the mass ratio of polyglutamic acid solution and pullulan solution ...

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Abstract

The invention discloses a medical dressing for hemostasis. The medical dressing for the hemostasis is prepared from the following raw materials in parts by weight: 50 parts of a polyglutamic acid-Pullulan cross-linked polymer, 20 to 30 parts of oat protein, 15 to 25 parts of cod skin collagen peptide, 10 to 20 parts of basophilic transparent keratin particles, 10 to 20 parts of glycolic acid, 5 to10 parts of garlic polysaccharide, and 5 to 15 parts of sodium hyaluronate. The invention further discloses a preparation method of the medical dressing for the hemostasis. The medical dressing for the hemostasis, disclosed by the invention, has good biocompatibility and biodegradability and excellent performance of high-efficiency hemostasis, bacteriostasis, tissue repair promotion and adhesionprevention, and further can quickly absorb water in blood while in contact with wounds, keep the environment moist and effectively close the bleeding wounds.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a hemostatic medical dressing and a preparation method thereof. Background technique [0002] Blood is an opaque red liquid that flows in the heart and blood vessels, and its main components are plasma, red blood cells, white blood cells, and platelets. Plasma accounts for about 55% of blood and is a mixture of water, sugar, fat, protein, potassium and calcium salts. Blood cells make up the other 45 percent of the blood. Clinical medicine points out that if the human body does not take effective first aid measures due to acute bleeding, the patient will die within 6-20 minutes. If the blood loss of the human body exceeds 20% of the whole body's blood volume (about 800cc for adults), shock will occur; if the blood loss exceeds 40% of the whole body's blood volume (about 1600cc for adults), it will be on the verge of death. According to statistics, the number of traumatic deaths...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/62A61L15/46A61L15/32A61L15/20A61L15/28A61L15/44A61L15/26
CPCA61L15/20A61L15/26A61L15/28A61L15/32A61L15/325A61L15/42A61L15/425A61L15/44A61L15/46A61L15/62A61L2300/216A61L2300/232A61L2300/252A61L2300/404A61L2300/412A61L2300/418A61L2300/45A61L2400/04C08L89/00C08L5/08C08L77/04C08L5/00
Inventor 张鹏舒泉水孙复钱黄日明
Owner INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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