Composite artificial bone material and preparation method thereof

A kind of artificial bone and artificial technology, applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve the problems of short residence time in the defect area, affect the bone healing effect, and the bone wax is not absorbed by the body, so as to promote osteoblasts Mature differentiation, low cost, and the effect of promoting bone healing

Inactive Publication Date: 2019-09-20
科先医疗科技(苏州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, collagen is relatively expensive, derived from animal tissue, prone to rejection, clinical manifestations of allergic reactions in patients and wound infection complications
Bone morphogenetic protein (BMP) is a growth and differentiation factor that can be used to promote local bone growth, but this protein degrades quickly and requires a large dose to maintain its effect, resulting in high cost; its physical and chemical properties are unstable, unlike other Difficulty maintaining activity when carrier is mixed; short residence time in defect area
[0003] Bone surgery often causes large wound bleeding. At present, bone wax is often used to seal fractures in clinical practice, but bone wax itself is not absorbed by the body, and excessive use can affect bone healing.

Method used

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  • Composite artificial bone material and preparation method thereof
  • Composite artificial bone material and preparation method thereof
  • Composite artificial bone material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0033] A preparation method of a composite artificial bone material, comprising the steps of: adding 15g PLGA to 100mL 1,4-dioxane, stirring at room temperature for 24h to completely dissolve it, adding 12g nano-hydroxyapatite and 8g of β-tricalcium phosphate, mixed evenly, added to the 3D printing material tank, adjusted the temperature of the low-temperature deposition platform to -30°C for printing and forming; freeze-dried the formed material at -40°C, vacuum degree less than 40Pa for 48 hours, and made porous bone stent, and then pour 5% sodium carboxymethyl starch into the porous bone stent under negative pressure, freeze-dry at -40°C and the vacuum degree is less than 40Pa for 48h, and then sterilize by electron beam irradiation to obtain the finished composite artificial bone (No. 1), the modified starch content is 2.9g, and the irradiation dose is 20kGy. The porous bone scaffold has a pore size of 206 μm and a porosity of 72%.

[0034] A 3D printing ink, the ink is m...

Embodiment 2

[0037]A preparation method of a composite artificial bone material, comprising the steps of: adding 12g PLGA to 100mL 1,4-dioxane, stirring at room temperature for 24h to completely dissolve it, adding 16g nano-hydroxyapatite and 2g of β-tricalcium phosphate, mixed evenly, added to the 3D printing material tank, adjusted the temperature of the low-temperature deposition platform to -30°C for printing and forming; freeze-dried the formed material at -40°C, vacuum degree less than 40Pa for 48 hours, and made porous bone stent, and then pour 6% sodium carboxymethyl starch into the porous bone stent under negative pressure, freeze-dry at -40°C and the vacuum degree is less than 40Pa for 48h, and then sterilize by electron beam irradiation to obtain the finished product of composite artificial bone (No. 2), the modified starch content is 2.6g, and the irradiation dose is 20kGy. The porous bone scaffold has a pore size of 231 μm and a porosity of 80%.

[0038] A 3D printing ink, th...

Embodiment 3

[0041] A preparation method of a composite artificial bone material, comprising the steps of: adding 15g PLGA to 100mL 1,4-dioxane, stirring at room temperature for 24h to completely dissolve it, adding 12g nano-hydroxyapatite and 8g of β-tricalcium phosphate, mixed evenly, added to the 3D printing material tank, adjusted the temperature of the low-temperature deposition platform to -30°C for printing and forming; freeze-dried the formed material at -40°C, vacuum degree less than 40Pa for 48 hours, and made porous bone The bracket is then sterilized by electron beam irradiation to obtain a composite artificial bone product (No. 3), and the irradiation dose is 20 kGy. The porous bone scaffold has a pore size of 201 μm and a porosity of 75%.

[0042] A 3D printing ink, the ink is made of the following raw materials in parts by weight: PLGA 15g, hydroxyapatite 12g, β-tricalcium phosphate 8g.

[0043] A composite artificial bone material, adding the 3D printing ink into a 3D prin...

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Abstract

The invention provides a preparation method of a composite artificial bone material. The preparation method includes steps: (1) dissolving PLGA into an organic solvent, adding nano hydroxyapatite and beta-tricalcium phosphate, and well mixing to obtain 3D printing ink; (2) subjecting the 3D printing ink to low-temperature deposition printing by 3D printing equipment, and performing freeze drying to obtain a porous bone scaffold; (3) performing negative-pressure pouring of modified starch solution into the porous bone scaffold, and carrying out freeze drying to obtain the composite artificial bone material; (4) subjecting the composite artificial bone material to irradiation sterilization to obtain an artificial bone finished product. The composite artificial bone material is prepared from PLGA, nano hydroxyapatite, beta-tricalcium phosphate and modified starch by compounding, and the modified starch is capable of quickly and effectively stopping bleeding in a bone surgery process and also promoting osteoblast maturation and differentiation.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a composite artificial bone material and a preparation method thereof. Background technique [0002] Large-scale bone defects caused by accidents or diseases are common clinical symptoms. At present, the main ways to treat bone defects include autologous bone, allogeneic bone and artificial bone material transplantation. However, due to the limited source of autologous bone and the formation of new bone defects on the patient's own donor site, the application of autologous bone is severely limited, and allogeneic bone is obtained from allografts, which causes disease transmission and rejection in clinical applications. Therefore, the application of allograft bone is also greatly limited. At present, the composite material of degradable carrier and growth factor is a hotspot in the research of bone tissue engineering, among which bone morphogenetic protein (BMP), collagen and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/20A61L27/50A61L27/56
CPCA61L27/12A61L27/18A61L27/20A61L27/50A61L27/56A61L2430/02C08L67/04C08L3/02
Inventor 吕国军
Owner 科先医疗科技(苏州)有限公司
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