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Preparation method of natural montmorillonite emergency haemostatic for external use

A technology of montmorillonite and hemostatic agent, applied in the field of preparation of external natural montmorillonite emergency life-saving hemostatic agent, to achieve the effect of reducing coagulation time, convenient application, and improved hemostatic performance

Active Publication Date: 2009-03-25
杭州沸创生命科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no domestic and foreign patent reports on the application of natural montmorillonite in blood coagulation materials, wound treatment and trauma repair, and the combination of natural montmorillonite with medical bandages and medical adhesives for trauma repair

Method used

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  • Preparation method of natural montmorillonite emergency haemostatic for external use
  • Preparation method of natural montmorillonite emergency haemostatic for external use
  • Preparation method of natural montmorillonite emergency haemostatic for external use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Choose Zhejiang Yuhang natural montmorillonite as raw material, the XRD patterns of Yuhang natural calcium montmorillonite, natural magnesium montmorillonite and natural sodium montmorillonite are attached figure 1 , see the original appearance of natural calcium montmorillonite and natural sodium montmorillonite figure 2 (Natural sodium montmorillonite on the left). The main components of natural montmorillonite are: silicon oxide, aluminum oxide, iron oxide, magnesium oxide, calcium oxide, sodium oxide, and potassium oxide. Wherein the total content of silicon oxide and aluminum oxide exceeds 70%. The mineral composition of natural montmorillonite is mainly montmorillonite, which has a regular layered structure (the interlayer distance is 0.90-2.0nm), and a relatively high specific surface area (30-1000m 2 / g), while its composition (silicon-aluminum ratio and the content of various ions) can be changed within a certain range.

[0028] Put a certain amount of Yuha...

Embodiment 2

[0030] With reference to the steps of Example 1, natural magnesium montmorillonite and sodium montmorillonite are selected, and the coagulation effect of the hemostatic agent is similar to that of the calcium montmorillonite hemostatic agent, see attached image 3 .

Embodiment 3

[0032] The natural calcium montmorillonite was heat-treated in a muffle furnace at 100°C, 300°C, 500°C, and 700°C for 4 hours. Figure 4 .

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Abstract

Disclosed is an external natural montmorillonite emergency life-saving hemostatic agent, which adopts natural montmorillonite as raw material; natural montmorillonite is composed of silica, titanium oxide, alumina, ferric oxide, magnesium oxide, calcium oxide, sodium oxide and potassium oxide; wherein, the total content of silica and alumina is more than 70%; the interlayer spacing of natural montmorillonite is 1.0- 2.0nm; the specific surface area of natural montmorillonite is 30-1000m2 / g; the preparation include the steps: a herbal grinder is adopted to crush the massive natural montmorillonite into particles with different sizes; the particle sizes of the particles are 1micron-1mm; the crushed natural montmorillonite or calcium montmorillonite processed with ion-exchange is processed for 1-24 hours under the temperature of 60- 900 DEG C to obtain external natural montmorillonite emergency life-saving hemostatic agent which has the advantages of simple preparation operation, rich raw materials, cheap price, easy obtaining, convenient application and good hemostatic effect.

Description

technical field [0001] The invention relates to an emergency life-saving hemostatic agent for treating fatal large vessel bleeding that cannot be controlled by conventional hemostatic measures and a preparation process thereof, in particular to a preparation method of an external natural montmorillonite emergency life-saving hemostatic agent. Background technique [0002] Life-Saving Rapid Hemostatic Agents (LSRHA) is an emerging research field in the world. LSRHA was developed primarily for emergencies in trauma where blood flow does not stop. An emergency like aortic bleeding can be contained within a short period of time (3 minutes), gaining valuable time for further medical treatment. [0003] At present, the research on LSRHA has just started abroad, and there are very few emergency life-saving hemostatic agents for moderate and severe bleeding in China. [0004] According to the statistics of the Ministry of Health in 2007, about 200 million person-times of various i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K33/06A61P7/04
Inventor 范杰李云龙肖丽萍胡笑月马桂岑
Owner 杭州沸创生命科技股份有限公司
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