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Temperature-sensitive hydrogel with hyperbranched structure and preparation method and application thereof

A temperature-sensitive, hydrogel technology, applied in the field of hydrogel, can solve problems such as unstable performance and wide molecular weight distribution range, achieve high swelling rate, uniform molecular weight distribution of copolymers, and ensure the effect of temperature-sensitive response performance

Active Publication Date: 2018-02-09
北京恒峰铭成生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the ternary clamp copolymer of the hydrogel of the invention has the disadvantages of wide molecular weight distribution range and unstable performance.

Method used

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  • Temperature-sensitive hydrogel with hyperbranched structure and preparation method and application thereof
  • Temperature-sensitive hydrogel with hyperbranched structure and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] A thermosensitive hydrogel with hyperbranched structure, the preparation method is as follows:

[0024] (1) Synthesis of hyperbranched RAFT reagent: 14 parts of 2-(propyltrithiocarbonate)-2-methylpropionyl chloride are dissolved in 40 parts of cyclohexanone, which is referred to as solution I; 30 parts of hyperbranched Put polyethyleneimine into the reactor, heat it to 50°C under stirring, then add solution I dropwise, after 0.5h dropwise addition, continue to react for 3h, then add 6 parts of 1,4-butane sultone Into the reactor, continue to react at 50°C for 5h, add ammonia solution to precipitate, filter the precipitate, wash with cyclohexanone, and vacuum dry to obtain hyperbranched RAFT reagent.

[0025] (2) Preparation of hydrogel: 30 parts of N-isopropylacrylamide, 20 parts of N-methacrylamide, 20 parts of vinylpyrrolidone, 12 parts of hyperbranched RAFT reagent in (1), 350 parts of water Add it into the reactor, mix well and heat to 82°C, add 8 parts of 8% potas...

Embodiment 2

[0027] A thermosensitive hydrogel with hyperbranched structure, the preparation method is as follows:

[0028] (1) Synthesis of hyperbranched RAFT reagent: 9 parts of 2-(methyltrithiocarbonate)-2-methylpropionyl chloride are dissolved in 26 parts of butyl acetate, which is referred to as solution I; 29 parts of hyperbranched Put polyethyleneimine into the reactor, heat it to 55°C under stirring, then add solution I dropwise, and continue the reaction for 2.5 hours after the addition of 1h, and then add 7 parts of 2-methyl-1,4-butanol Add sultone into the reactor, continue to react at 55°C for 6h, add ammonia solution to precipitate, filter the precipitate, wash with butyl acetate, and vacuum dry to obtain hyperbranched RAFT reagent.

[0029] (2) Preparation of hydrogel: 25 parts of N-isopropylacrylamide, 10 parts of N-methacrylamide, 5 parts of N-ethylacrylamide, 27.5 parts of vinylpyrrolidone, 8 parts of (1) Add hyperbranched RAFT reagent and 320 parts of water into the reac...

Embodiment 3

[0031] A thermosensitive hydrogel with hyperbranched structure, the preparation method is as follows:

[0032] (1) Synthesis of hyperbranched RAFT reagent: 11 parts of dithioacetate chloride ethyl esters are dissolved in 32 parts of acetone, which is referred to as solution I; 25 parts of hyperbranched polyethyleneimines are put into the reactor and stirred Heat to 45°C, then add solution I dropwise, continue to react for 3h after 0.5h dropwise addition, then add 5.6 parts of 1-methyl-1,4-butane sultone into the reactor, continue at 45°C Reaction 5, after adding ammonia solution to precipitate, filter the precipitate, wash with acetone, and dry in vacuum to obtain hyperbranched RAFT reagent.

[0033] (2) Preparation of hydrogel: 12 parts of N-isopropylacrylamide, 15 parts of N-methacrylamide, SR14 parts of N-ethylacrylamide, 24 parts of vinylpyrrolidone, 14 parts of (1) Add hyperbranched RAFT reagent and 250 parts of water into the reactor, mix well and heat to 90°C, add 7 pa...

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Abstract

The invention relates to a temperature-sensitive hydrogel with hyperbranched structure and a preparation method and application thereof. The temperature-sensitive hydrogel is macromolecular hydrogel of three-dimensional mesh structure using hyperbranched polyethyleneimine as a center and having uniform molecular weight distribution. A hyperbranched RAFT (reversible addition-fragmentation chain transfer polymerization) reagent is prepared first, polymerization of temperature-sensitive monomer and vinyl pyrrolidone is initiated by means of RAFT aqueous solution polymerization, a room-temperatureself-crosslinked monomer is added for polymerization, and the temperature-sensitive hydrogel is prepared. The temperature-sensitive hydrogel and the preparation method and application thereof have the advantages that the synthesis of temperature-sensitive hydrogel with hyperbranched structure by using the hyperbranched polyethyleneimine as a center is reported for the first time; the self-crosslinked monomer added in the final stage of the hydrogel RAFT polymerization process has higher hyperbranched branch molecular weight, and the hydrogel has higher swelling rate; the hydrogel is preparedby means of the RAFT aqueous solution polymerization, the molecular weight stability and temperature-sensitive responsiveness of the hydrogel are guaranteed, and a biological environment can be simulated.

Description

technical field [0001] The invention relates to a hydrogel, in particular to a temperature-sensitive hydrogel with a hyperbranched structure and a preparation method and application thereof, belonging to the field of hydrogel technology. technical background [0002] At present, poly(N-isopropylacrylamide) and its derivatives are the most researched temperature-sensitive hydrogels. As a typical heat-shrinkable temperature-sensitive hydrogel, PNIPAM hydrogels are relatively The transition temperature is about 32°C, which is very close to the normal body temperature of the human body at about 37°C. When the temperature is lower or higher than 32°C, PNIPAM hydrogel is in a state of swelling or deswelling in water respectively. The swelling and deswelling rate, also known as the response rate, is an important parameter to measure the thermosensitive properties of thermosensitive hydrogels. [0003] Chinese patent CN201310072360.8 discloses a temperature-sensitive hydrogel, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F283/00C08F220/54C08F226/10C08F220/58
CPCC08F283/00C08F2438/03C08F220/54C08F226/10
Inventor 陈晨特
Owner 北京恒峰铭成生物科技有限公司
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