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Clinical first-aid hemostatic material

A technology of hemostatic materials and raw materials, which is applied in the hemostatic materials used in clinical medicine and its preparation field. It can solve the problems of insufficient water absorption rate and saturated water absorption rate of starch, hidden dangers of fibrin glue virus, and unsatisfactory hemostatic effect. Low dependence, better hemostatic performance, and excellent hemostatic function

Inactive Publication Date: 2020-12-25
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These hemostatic materials are widely used in surgical hemostasis, and have achieved certain hemostatic effects in clinical and animal experiments, but they also have certain defects or hidden dangers, such as tissue necrosis caused by zeolite and oxidized regenerated cellulose, and allergic reactions caused by collagen , local adhesions formed by gelatin and cellulose ethers, fibrin glue may be a potential virus hidden danger, the water absorption rate and saturated water absorption rate of starch itself are not high enough, and the viscosity after water absorption is poor, so it cannot form an effective effect on damaged tissues and blood vessels. Viscous blockage, easy to be washed away by blood flow, less than ideal hemostatic effect, etc.
These hemostatic materials generally have disadvantages such as poor air permeability and slow wound healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A hemostatic material, made of the following raw materials in parts by weight: 70 parts of cyclodextrin-based polyvinyl glycine copolymer, 5 parts of N-(3-triethoxysilylpropyl) glucamide modified carbon sponge , chitosan modified Agrimony powder 1 part.

[0027] The preparation method of the cyclodextrin-based polyvinyl glycine copolymer comprises the following steps: 23 g of vitamin K, 10 g of L-vinyl glycine, 8 g of allyl cyclodextrin, and 1 g of allyl diglycol dicarbonate , 5 g of polyethylene glycol monoallyl ether, and 0.2 g of azobisisobutyronitrile were dissolved in 100 g of dimethyl sulfoxide, stirred and reacted for 3 hours under a nitrogen atmosphere, then precipitated in ethanol, and washed 3 times with acetone , and then placed in a vacuum drying oven at 80° C. for 10 hours to obtain a cyclodextrin-based polyvinyl glycine copolymer.

[0028] The preparation method of the N-(3-triethoxysilylpropyl) glucamide modified carbon sponge comprises the following ste...

Embodiment 2

[0034] A hemostatic material, made of the following raw materials in parts by weight: 73 parts of cyclodextrin-based polyvinyl glycine copolymer, 7 parts of N-(3-triethoxysilylpropyl) glucamide modified carbon sponge , 2 parts of chitosan modified Agrimony powder.

[0035] The preparation method of the cyclodextrin-based polyvinyl glycine copolymer comprises the following steps: 23 g of vitamin K, 10 g of L-vinyl glycine, 8 g of allyl cyclodextrin, and 1 g of allyl diglycol dicarbonate , 5 g of polyethylene glycol monoallyl ether, 0.25 g of azobisisoheptanonitrile were dissolved in 115 g of N,N-dimethylformamide, stirred and reacted for 3.5 hours under a helium atmosphere, and then precipitated in ethanol , and washed 4 times with acetone, and then placed in a vacuum drying oven at 82° C. for 11 hours to obtain a cyclodextrin-based polyvinyl glycine copolymer.

[0036] The preparation method of the N-(3-triethoxysilylpropyl) glucamide modified carbon sponge comprises the foll...

Embodiment 3

[0042] A hemostatic material, made of the following raw materials in parts by weight: 75 parts of cyclodextrin-based polyvinyl glycine copolymer, 8 parts of N-(3-triethoxysilylpropyl) glucamide modified carbon sponge , 3 parts of chitosan modified Agrimony powder.

[0043] The preparation method of the cyclodextrin-based polyvinyl glycine copolymer comprises the following steps: 23 g of vitamin K, 10 g of L-vinyl glycine, 8 g of allyl cyclodextrin, and 1 g of allyl diglycol dicarbonate , 5 g of polyethylene glycol monoallyl ether, 0.3 g of azobisisobutyronitrile were dissolved in 135 g of N-methylpyrrolidone, stirred and reacted for 4 hours under a neon atmosphere, and then precipitated in ethanol, and washed with acetone 5 times, and then baked in a vacuum oven at 83°C for 12.5 hours to obtain a cyclodextrin-based polyvinylglycine copolymer.

[0044] The preparation method of the N-(3-triethoxysilylpropyl) glucamide modified carbon sponge comprises the following steps: placi...

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PUM

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Abstract

The invention discloses a clinical first-aid hemostatic material. The clinical first-aid hemostatic material is prepared from the following raw materials in parts by weight of 70-80 parts of a cyclodextrin-based polyvinyl glycine copolymer, 5-10 parts of N-(3-triethoxysilyl propyl) glucosamide modified carbon sponge and 1-5 parts of chitosan modified hairyvein agrimony powder. The preparation method of the cyclodextrin-based polyvinyl glycine copolymer comprises the following steps of dissolving vitamin K2, L-vinyl glycine, allyl cyclodextrin, allyl diethylene glycol dicarbonate, polyethyleneglycol monoallyl ether and an initiator in a high-boiling-point solvent, and carrying out a stirring reaction for 3-5 h in a nitrogen or inert gas atmosphere; and then precipitating in ethanol, washing with acetone for 3-5 times, and drying in a vacuum drying oven at the temperature of 80-85 DEG C for 10-15 hours to obtain the cyclodextrin-based polyvinyl glycine copolymer. The hemostatic materialdisclosed by the invention is more remarkable in hemostatic effect, shorter in hemostatic time, more economical and better in use safety.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and relates to a hemostatic material and a preparation method thereof, in particular to a hemostatic material used in clinical medicine and a preparation method thereof. Background technique [0002] Rapid and thorough hemostasis during surgery, reducing the amount of bleeding, and keeping the operative field clear are one of the cores of basic surgical operations. In all kinds of first aid, such as frequent traffic and accidents, it is also generally faced with problems such as rapid and effective hemostasis, relief of patients' pain, and saving people's lives. The efficiency of hemostasis is the main reason to measure the success of emergency surgery. Rapid hemostasis and functional hemostasis are important means to save lives and an important part of clinical treatment, and effective hemostasis is a necessary guarantee for the safety of patients' lives. With the rapid development o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00A61L24/04A61L24/02
CPCA61L24/0005A61L24/001A61L24/0036A61L24/02A61L24/06A61L24/08A61L2400/04C08L5/08C08L5/04C08L51/02
Inventor 万迎春朱水寿邓生卫
Owner 湖南博隽生物医药有限公司
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