The invention discloses a chemical reaction system for producing oxalic acid diester and oxalic acid as main products by using sodium formate as raw materials. The chemical reaction system comprises a first reaction unit, a second reaction unit and a third reaction unit, wherein the sodium formate is subjected to dehydrogenation reaction to generate sodium oxalate in the first reaction unit; in the second reaction unit, the sodium oxalate is mixed with solvents, then, the oxalic acid is added, the reaction is carried out, and then, the solid and liquid separation is carried out, wherein the solid phase is phosphate, and the oxalic acid diester is rich in the liquid phase; and in the third reaction unit, the oxalic acid diester-rich liquid phase is subjected to distillation separation, then, the oxalic acid diester is respectively subjected to hydrolysis, hydrogenolysis and ammonolysis, and oxalic acid, alcohol, glycol and oxamide are obtained. The chemical reaction system disclosed by the invention has the advantages that the influence on environment is avoided, the environment problems of lead-containing sewage and other waste discharge do not exist, phosphates from sodium ions and with higher additional values are generated, the process separation becomes simple, the implementation is easy, and the production process reaches the requirements of clean production and energy saving environment-friendly type production process.