31results about How to "Solving Clarity Issues" patented technology

The invention provides an omeprazole sodium lyophilized powder for injection (pH of 10.8-11.2), comprising omeprazole sodium as the main active component, as well as excipient, metal ion complexing agent, stabilizer, antioxidant and pH regulator. The omeprazole sodium lyophilized powder for injection has higher active component content than that of the conventional omeprazole sodium injection, solves solution clarity problem, and effectively prevents loss of bone calcium due to complexation with calcium ion. The omeprazole sodium lyophilized powder for injection also has the advantages of stable color and properties, low side effects, good stability, good redissolution, and convenient application.

The invention provides a production method of gluvosamine hydrochloride relating to a production technique of chemical raw material. The production method comprises acidolysis, decolouration, press filtration, purification, concentration, crystallization, baking, grinding, cribration, and packaging. In the process of production, the products of the invention regulates the proportion between hydrochloric acid and chitin to 5 to 1 under the temperature of 85 DEG C to 88 DEG C for three hours, activated carbon is added in a reaction container directly to decolor without refrigeration and crystallization, which omits the steps of separation of crude crystallization and water solution, thus saving time and water. The crude liquid after being filtered through a press filter is not directly concentrated but is filtered by ultrafiltration system to remove oil and fat and inorganic salts, which solves the problem of clarity and luminous transmittance of products and improves production quality.

The invention provides a honeysuckle compound beverage and a preparation method thereof. The preparation method comprises the following steps: mixing honeysuckle and cassia seed in proportion for extraction to prepare extracting solution of the honeysuckle and the cassia seed; and mixing 40 to 60 percent of the extracting solution, 3.0 to 10 percent of sweetener, 1.0 to 2.0 percent of honey, 0.05 to 0.3 percent of acidity regulator, 0.05 to 0.2 percent of stabilizer and the balance of pure water to prepare a fashion beverage having special flavors of the honeysuckle and the cassia seed and the effects of clearing heat and releasing toxin, dispelling wind and heat, protecting liver, reducing blood pressure and the like. When the honeysuckle and the cassia seed are extracted, a special flocculating agent microcrystalline cellulose is adopted, and centrifugation and membrane separation are combined, so the clarity and stability of the extract are improved, the mouthfeel of the compound beverage is improved and the clarity of the beverage is improved. The product has stable quality, has the quality guarantee period reaching 24 months, and is suitable for industrial production.

The invention relates to a preparation method of traditional Chinese medicine houttuynia cordata injection, which comprises the following steps: distilling fresh houttuynia cordata with water vapor, collecting coarse distillate, redistilling, collecting heavy distillate, adding 7g of sodium chloride, 5g of polysorbate 80, mixing, adjusting the pH value to be 4.0-6.0 with a pH regulating agent, mixing to be uniform, filtering with a 0.45Mum filter element and a 0.22Mum filter element, filling and sealing, sterilizing for 30 minutes at 105 DEG C, carrying out light inspection, and packaging, thereby preparing the houttuynia cordata injection. The houttuynia cordata injection has the effects of clearing heat, removing toxicity, eliminating carbuncle and abscess, promoting diuresis and treating stranguria, and has significant clinical treatment effects on lung abscess caused by phlegm heat and obstructed lung, urinary tract infection caused by downward flow of dampness-heat, and furuncle and carbuncle caused by heat-toxicity obstruction.

A technology for preparing salviae miltiorrhizae oral liquid with a ceramic membrane is characterized by comprising the following steps of decoction, concentration, centrifugal filtration through a high-speed centrifuge, primary filtering by ceramic membrane with the hole diameter of 150000-180000 molecular weight, secondary filtering by ceramic membrane with the hole diameter of 80000-120000 molecular weight, ultrafiltration by ceramic membrane with the hole diameter of 20000-50000 molecular weight, nanofiltration concentration by ceramic membrane with the hole diameter of 300-450 nanometers, concentrating medicine liquid to the amount 2.5-3.5 times that of medicinal materials, final preparation and embedment sterilization. Heating processes in the whole technology course are reduced, ceramic membrane filtering with different molecular weights and refining under normal temperature are carried out, impurities are effectively removed, effective constituents are reserved to the maximum degree, an extracting technology is shortened, pollution is lowered, energy is saved, clean production is achieved, the technology accords with traditional Chinese medicine theoretical system, an ultrafiltration membrane filtering technology is used, degerming and pyrogen effect is good, and the clarity of medicine liquid is guaranteed and improved.

The invention provides novel ceftriaxone disodium and a preparation method thereof. The preparation method comprises the steps of: reacting7-ACT with AE-active ester in nitrogen protection, in a solvent, and under the action of an amine intermediate reactant; adding a stabilizer into the reactant; and adding a salt forming agent into the mixture to react and crystallize to prepare the ceftriaxone disodium, wherein the stabilizer is sodium sulfate, sodium polyacrylate or sodium alga acid. Meanwhile, ash residues of halogenated (brominated) butyl rubber plug on a cap are below 35 percent, and the sulfide content is lower than 8 mu g/20cm<2>, so that the volatile component antioxidant 264 (BHT) in the butyl rubber plug is prevented from migrating to medicament from the rubber plug in a medicament storage process, medicament dissolution is reduced and clearance degree of medicament solution is reduced.

The invention discloses a refining method of ginkgo flavone and preparing method of ginkgo damo injection, which comprises the following steps: adding ginkgo extract in the dimidamo with pH value at 3.0-6.5, setting temperature at 100 deg.c to react, sedimenting at low temperature, hyperfiltering, sterilizing, adopting NaHSO3 as anti-oxidant.

The invention relates to a preparation method for traditional Chinese medicine earthworm injection. The earthworm injection is prepared by the following steps of: performing water extraction on Guangdong earthworm twice, and precipitating the extract twice with ethanol; adding a bacteriostat and regulating the pH value by using a pH regulator; and filtering with a 0.45-micron filter element and a 0.22-micron filter element, filling, sealing, sterilizing, checking with a lamp and packaging. The earthworm injection has the effect of relaxing smooth muscles and obvious effect of clinically treating cough and asthma caused by bronchial asthma.

The invention discloses a method for reducing turbidity and removing visible foreign matters of sugammadex sodium. The method comprises the following steps: taking an aqueous solution of sugammadex sodium, heating and stirring under the protection of inert gas, separating out substances causing turbidity and/or substances capable of forming visible foreign matters in the aqueous solution of sugammadex sodium, filtering, and reducingthe turbidity and removing the visible foreign matters of sugammadex sodium. Themethod is simple and convenient to operate, low in cost, remarkable in removal effect and stable in product quality, and can be industrially applied; the technical problems of clarity and visible foreign matters of sugammadex sodium caused by freeze-drying, spray-drying, poor solventcrystallization, reduced-pressure evaporation drying, crushing and the like at present are efficiently solved, and the quality safety of a sugammadex sodium finished product is improved.

The invention relates to a preparation method of high-purity fluorescein sodium. The preparation method comprises the following steps of: acetylating by using crude fluorescein sodium as the raw material and acetic anhydride as an acetylation reagent; recrystallizing the acetylated fluorescein; hydrolyzing; and salifying to obtain high-purity fluorescein sodium. In the preparation process of the obtained fluorescein sodium, the acetylation solvent is mild and can finish a reaction in a relatively short time without adding a catalyst so that the reaction cost is lower and the obtained product is safer.

The invention relates to tussah moth prepared health care wine and a brewing method thereof. The brewing method comprises the following steps: preparing tussah moth stock solution wine, preparing medicinal and edible dual-purpose traditional Chinese medicinal material extracted stock solution wine, blending to prepare fresh tussah moth extracted stock solution wine and medicinal and edible dual-purpose traditional Chinese medicinal material extracted stock solution wine mixed liquor, and filtering and clarifying the tussah moth traditional Chinese medicinal material mixed liquor prepared in the step 3 to obtain finished tussah moth mixed liquor. The method is reasonable and feasible, design is skillful, mouthfeel is soft, the wine is mellow in wine body, harmonious in medicine fragrance, amber-like in color and crystal clear, can adjust various physiological functions, supplement metabolic consumption, improve immunity, promote human body development, resist fatigue and improve sexualfunctions, and solves the problems that most tussah moth wine on the market in recent years is not ideal in taste, color and clarity, embodies heavy fishy smell of tussah moth and inharmonious traditional Chinese medicine flavor and is difficult to drink; the wine is turbid and precipitated with impurities, compared with the prior art, the method has the advantages that the technical problems thatthe market development of products is restricted and the like are solved, and the method has good market prospect and development space.

The invention relates to a preparation method for a Chinese medicinal Chinese thorowax root injection. The preparation method disclosed by the invention comprises the following steps of: distilling Chinese thorowax root with water steam; collecting a primary distillate; redistilling; collecting a redistillate; adding polysorbate 80 and sodium chloride; mixing uniformly; adjusting the pH value to 4.0-7.0 with a pH adjusting agent; uniformly stirring; filtering with filter cores of 0.45 mum and 0.22 mum, and encapsulating; sterilizing at the temperature of 105 DEG C for 30 minutes; performing light inspection; and packing to obtain the Chinese thorowax root injection. The Chinese thorowax root injection has the effects of clearing heat and relieving exterior syndrome, and has remarkable clinical curative effects on fever caused by cold, influenza, malaria and the like.

The invention discloses a method for improving the clarity of resorcinol. The method comprises the following steps that resorcinol is dissolved through a saturated sodium chloride water solution, anda resorcinol solution is obtained; an organic solvent I is added into the resorcinol solution to conduct extraction; active carbon is added into the organic phase obtained through extraction to conduct decoloration, anhydrous sodium sulfate is utilized to conduct dehydration, and then filtration is conducted; and the obtained filtrate is subjected to vacuum concentration at the temperature of 20-30 DEG C, then an organic solvent II is added to conduct pulping and filtration, a filter cake is dried in vacuum, and resorcinol is obtained. The turbidity of resorcinol obtained by adopting the method can meet the Europe pharmacopoeia criterion.

The invention discloses a honeysuckle plant beverage formula and a preparation method thereof. A sugar-containing formula comprises 89.79% of purified water, 5.5% of high fructose corn syrup, 4.5% of white granulated sugar, 0.17% of honeysuckle and 0.04% of citric acid; and a sugar-free formula comprises 99.74% of purified water, 0.17% of honeysuckle, 0.04% of citric acid, 0.02% of acesulfame potassium, 0.02% of sodium cyclohexylsulfamate and 0.01% of aspartame (containing phenylalanine). The honeysuckle plant beverage formula has the advantages of clearing blood poison, dispelling wind heat, preventing cold, being beneficial to body health and being convenient to popularize and drink.

The invention discloses a composite honeysuckle beverage and a preparation method thereof, and belongs to the technical field of foods. The beverage is prepared from the following components in percentage by mass: 30 to 50 percent of honeysuckle flower extracting solution, 5 to 10 percent of herba taraxaci extracting solution, 5 to 10 percent of flos chrysanthemi extracting solution, 3.5 to 5 percent of xylitol, 0.1 to 0.3 percent of sodium alginate, 0.1 to 0.5 percent of a stabilizing agent and the balance of purified water. According to the method, a traditional dry flower extraction mode ofhoneysuckle dew is broken through, the freshly picked honeysuckles with a flowering rate of 25%-50% and branch and leaf rate of 3% or below are screened and directly distilled and extracted, and functional substances of the honeysuckles are fully reserved. The honeysuckle beverage prepared by the preparation method disclosed by the invention contains most of water-soluble components of honeysuckles, so that the functional effect of the honeysuckles is retained; and meanwhile, the problems of clarity and stability are solved, and the product is refreshing, delicious, clear and transparent.

The invention relates to a preparation method for a traditional Chinese medicinal pubescent holly root injection. The preparation method comprises the following steps of: performing water extraction on the pubescent holly root for three times; ultra-filtering the extract, performing alcohol precipitation, acid precipitation and alcohol precipitation again; regulating the pH value by using a pH regulator; filtering by using filter elements with the diameter of 0.45 microns and 0.22 microns, and encapsulating, sterilizing, performing lamp inspection and packaging to obtain the pubescent holly root injection. The pubescent holly root injection has the effects of expanding blood vessels, sterilizing and diminishing inflammation, and has remarkable curative effect of treating coronary arteriosclerotic heart diseases, thromboangitis obliterans, central retinitis and children pneumonia.

The invention provides a preparation method of honeysuckle drinking water, and belongs to the technical field of honeysuckle drinking water. The method comprises the following steps of selecting a honeysuckle raw material, namely taking honeysuckle and honeysuckle leaves, cleaning, draining, crushing into long sections, pouring the crushed honeysuckle raw material into a stainless steel pot, adding domestic drinking water according to a mass ratio of the raw material to water of 1: 1.6, adding an aqueous alkali solution with a pH value of 8-14 and an amount of 20-30 times of the weight of the raw material, soaking for 30-40 minutes, heating to boil, boiling with slow fire for 20-30 minutes, collecting distillate which is 10-25 times of the weight of the raw materials, separating honeysuckle dregs and honeysuckle filtrate with filter cloth while the distillate is hot, and processing the honeysuckle filtrate and the honeysuckle dregs in different ways to obtain a honeysuckle extracting solution and aromatic water correspondingly. The honeysuckle drinking water provided by the invention has the efficacy of decreasing internal heat, and also has the effects of promoting reproduction of gastrointestinal tract bacteria and improving gastrointestinal tract environment and functions.