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Preparation method for traditional Chinese medicine earthworm injection

A technology for injections and earthworms, which can be used in pharmaceutical formulations, drug delivery, drug combinations, etc., and can solve problems such as industrialization difficulties and high production costs

Inactive Publication Date: 2010-12-01
裘建社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the industrialization of this method has certain difficulties, and the production cost is relatively high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Take 1000g of Guangdilong, after cleaning and washing, add water to decoct twice, 60 minutes each time, filter the decoction, concentrate the filtrate to a liquid ointment with a relative density of 1.1-1.15 (50°C), combine, add ethanol for precipitation treatment For the second time, the alcohol content in the solution is 60% for the first time, and 80% for the second time. Let it stand for 48 hours each time, filter, and recover the ethanol from the filtrate until it has no alcohol smell, add three times the amount of water for injection, and stir evenly. Refrigerate for 48 hours, filter, put the filtrate in a suitable container, seal, heat and press at 105°C for 30 minutes, let cool, refrigerate for 48 hours, filter, add 0.3% activated carbon to the filtrate, boil for 15 minutes, let cool, filter, collect The filtrate is the purified solution; take 500ml of water for injection in the liquid preparation tank, add 803ml of polysorbate, heat and stir to dissolve, add the...

Embodiment 2

[0012] Take 50kg of Guangdilong, after cleaning and washing, add water to decoct twice, 60 minutes each time, filter the decoction, concentrate the filtrate to a liquid ointment with a relative density of 1.1-1.15 (50°C), combine, add ethanol for precipitation treatment For the second time, the alcohol content in the solution is 60% for the first time, and 80% for the second time. Let it stand for 48 hours each time, filter, and recover the ethanol from the filtrate until it has no alcohol smell, add three times the amount of water for injection, and stir evenly. Refrigerate for 48 hours, filter, put the filtrate in a suitable container, seal, heat and press at 105°C for 30 minutes, let cool, refrigerate for 48 hours, filter, add 0.3% activated carbon to the filtrate, boil for 15 minutes, let cool, filter, collect The filtrate is the purified solution; take 25000ml of water for injection in the liquid preparation tank, add 150ml of polysorbate 80, heat and stir to dissolve, add...

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Abstract

The invention relates to a preparation method for traditional Chinese medicine earthworm injection. The earthworm injection is prepared by the following steps of: performing water extraction on Guangdong earthworm twice, and precipitating the extract twice with ethanol; adding a bacteriostat and regulating the pH value by using a pH regulator; and filtering with a 0.45-micron filter element and a 0.22-micron filter element, filling, sealing, sterilizing, checking with a lamp and packaging. The earthworm injection has the effect of relaxing smooth muscles and obvious effect of clinically treating cough and asthma caused by bronchial asthma.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine earthworm preparation, in particular to a preparation method of a traditional Chinese medicine earthworm injection. Background technique [0002] The scientific name of the traditional Chinese medicine Dilong is earthworm, which is the whole body of the giant worm family animal ginseng ringworm or the Orthoworm family animal dorsal lip worm. It is cold in nature and salty in taste. It is one of the important traditional Chinese medicines commonly used in my country. Modern studies have found that Earthworm has various pharmacological activities such as thrombolysis, anti-tumor, antihypertensive, antiasthma, and diuresis. In recent years, Earthworm has been more and more widely used in TCM clinical and Chinese patent medicine production. The mainstream medicinal species recorded in the Chinese Pharmacopoeia is the giant worm, which is called "Guangdilong", which is mainly di...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/08A61P11/06A61P11/14A61K35/62
Inventor 裘建社何国增
Owner 裘建社
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