Preparation method for traditional Chinese medicinal pubescent holly root injection

A technology of holly holly and injection, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., and can solve problems such as unstable quality and poor clarity

Inactive Publication Date: 2011-05-25
裘建社
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the injection made from Maodongqing

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Take 1000g of holly holly, after net selection and washing, add water and decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine, ultrafiltration (molecular weight cut-off is 30000~50000), and the ultrafiltrate is concentrated under reduced pressure to The relative density is 1.15~1.18 (50°C), combined, add ethanol to make the alcohol content reach 70%, stir evenly, store in refrigerator for 24 hours, filter, recover ethanol from the filtrate under reduced pressure, let cool to room temperature, add water for injection to relative density The density is 1.05, stir evenly, adjust the pH value to 2.5 with hydrochloric acid solution, let it stand for precipitation, filter, adjust the pH value of the filtrate to 6.0 with sodium hydroxide solution, keep it refrigerated for 12 hours, filter, and concentrate the filtrate to a relative density under reduced pressure About 1.20~1.23 (50°C), add ethanol to make the alcohol content reach...

Embodiment 2

[0011] Take 1000g of holly holly, after cleaning and washing, add water and decoct three times, the first time for 3 hours, the second and third times for 1.5 hours each, combine, ultrafiltration (molecular weight cut-off is 30000~50000), and the ultrafiltrate is concentrated under reduced pressure to The relative density is 1.15~1.18 (50°C), combined, add ethanol to make the alcohol content reach 70%, stir evenly, keep in refrigerator for 48 hours, filter, recover ethanol from the filtrate under reduced pressure, let cool to room temperature, add water for injection to relative density The density is 1.08, stir evenly, adjust the pH value to 2 with 10% hydrochloric acid solution, let it stand for precipitation, filter, adjust the pH value of the filtrate to 6.5 with 20% sodium hydroxide solution, place it in refrigeration for 12 hours, filter, and decompress the filtrate Concentrate to a relative density of about 1.20-1.23 (50°C), add ethanol to make the alcohol content reach ...

Embodiment 3

[0013] Get 500kg of holly holly, after cleaning and washing, add water and decoct three times, for the first time for 2 hours, for the second and third times for 1 hour respectively, combine, ultrafilter (molecular weight cut-off is 30000~50000), and the ultrafiltrate is concentrated under reduced pressure to The relative density is 1.15~1.18 (50°C), combined, add ethanol to make the alcohol content reach 70%, stir evenly, keep in refrigerator for 48 hours, filter, recover ethanol from the filtrate under reduced pressure, let cool to room temperature, add water for injection to relative density The density is 1.05, stir evenly, adjust the pH value to 2 with 10% hydrochloric acid solution, let it stand for precipitation, filter, adjust the pH value of the filtrate to 6.0 with 20% sodium hydroxide solution, place it in refrigeration for 12 hours, filter, and decompress the filtrate Concentrate to a relative density of about 1.20-1.23 (50°C), add ethanol to make the alcohol conten...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a preparation method for a traditional Chinese medicinal pubescent holly root injection. The preparation method comprises the following steps of: performing water extraction on the pubescent holly root for three times; ultra-filtering the extract, performing alcohol precipitation, acid precipitation and alcohol precipitation again; regulating the pH value by using a pH regulator; filtering by using filter elements with the diameter of 0.45 microns and 0.22 microns, and encapsulating, sterilizing, performing lamp inspection and packaging to obtain the pubescent holly root injection. The pubescent holly root injection has the effects of expanding blood vessels, sterilizing and diminishing inflammation, and has remarkable curative effect of treating coronary arteriosclerotic heart diseases, thromboangitis obliterans, central retinitis and children pneumonia.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine Maodongqing preparation, in particular to a preparation method of a Chinese medicine Maodongqing injection. Background technique [0002] The traditional Chinese medicine Ilex pubescens is the root of Ilex pubescens Hook.et Arn., a plant of the Ilex family. It is mainly produced in Guangdong, Guangxi, Jiangxi, Anhui, Fujian and other places. It has the effects of promoting blood circulation, reducing swelling and relieving pain, clearing heat and detoxifying, and is widely used in the treatment of angina pectoris, myocardial infarction, thromboangiitis obliterans, central retinitis, tonsillitis, pharyngitis, and children's pneumonia. Efficacy. Maodongqing injection is a sterilized aqueous solution made of Maodongqing single herb, which has the effects of dilating blood vessels and antibacterial and anti-inflammatory effects. For coronary heart disease, thromboangiitis obl...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/185A61K9/08A61P9/10A61P9/14A61P27/02A61P11/00A61K125/00
Inventor 裘建社何国增曾德智
Owner 裘建社
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap