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Refining method of ginko total flavone and method for preparing ginko damo injection

A technology of total flavonoids of Ginkgo biloba and a refining method, which is applied in the directions of medical raw materials derived from Ginkgo biloba, medical preparations containing active ingredients, blood diseases, etc., can solve the problems of decreased content, deepened color, unqualified products, etc. The effect of oxidation, maintenance of drug safety, and guarantee of drug quality

Active Publication Date: 2009-06-10
HUNAN SAILONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Since the total flavonoids of Ginkgo biloba and dipyridamole are obviously oxidizable, even if the product is filled with N 2 protection, it will also deepen the color in a short period of time, and the content will drop, making the product unqualified

Method used

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  • Refining method of ginko total flavone and method for preparing ginko damo injection
  • Refining method of ginko total flavone and method for preparing ginko damo injection
  • Refining method of ginko total flavone and method for preparing ginko damo injection

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Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0049] Embodiment one: the refining method of ginkgo total flavonoids of the present invention comprises the following steps:

[0050] 1. Add 100L of water for injection to 10Kg of ginkgo biloba extract, heat and stir until dissolved;

[0051] 2. Put the above solution in an acid-resistant container, add dipyridamole 400g, NaHSO 3 100g, adjust the pH value of the solution to 4.0 with hydrochloric acid, and continue heating to 100°C;

[0052] 3. Cool down to room temperature in a water bath, then place in a refrigerator, and refrigerate at 0-10°C for 12 hours or more. Take the supernatant after sedimentation, and use a 0.45um microporous membrane as the medium to filter the plate and frame;

[0053] Four, the filtrate gained in step 3 is ultrafiltered by an ultrafilter with a molecular weight cut-off of 10,000 Daltons, and the ultrafiltrate obtained is fully stirred;

[0054] 5. Transport the ultrafiltrate obtained in step 4 to an infusion bag for packaging with a peristaltic...

Embodiment approach 2

[0055] Embodiment two: the refining method of ginkgo total flavonoids of the present invention comprises the following steps:

[0056] 1. Add 80L of water for injection to 5Kg of ginkgo biloba extract, heat and stir until dissolved;

[0057] 2. Put the above solution in an acid-resistant container, add dipyridamole 100g, NaHSO 3 80g, adjust the pH value of the solution to 3.0 with hydrochloric acid, and continue heating to 80°C;

[0058] 3. Cool down to room temperature in a water bath, then place in a refrigerator, refrigerate at OC for 12 hours, take the supernatant after sedimentation, and use a 0.45um microporous membrane as the medium to filter the plate and frame;

[0059] Four, the filtrate gained in step 3 is ultrafiltered by an ultrafilter with a molecular weight cut-off of 10,000 Daltons, and the ultrafiltrate obtained is fully stirred;

[0060] 5. Transport the ultrafiltrate obtained in step 4 to an infusion bag for packaging with a peristaltic pump, seal it with ...

Embodiment approach 3

[0061] Embodiment three: the refining method of ginkgo total flavonoids of the present invention comprises the following steps:

[0062] 1. Add 100L of water for injection to 10Kg of ginkgo biloba extract, heat and stir until dissolved;

[0063] 2. Put the above solution in an acid-resistant container, add dipyridamole 400g, NaHSO 3 100g, adjust the pH value of the solution to 6.5 with hydrochloric acid, and continue heating to 100°C;

[0064] 3. Cool down to room temperature in a water bath, then place it in a refrigerator, and refrigerate at 10°C for more than 12 hours. Take the supernatant after sedimentation, and filter it with a 0.45um microporous membrane as the medium;

[0065] Four, the filtrate gained in step 3 is ultrafiltered by an ultrafilter with a molecular weight cut-off of 10,000 Daltons, and the ultrafiltrate obtained is fully stirred;

[0066] 5. Transport the ultrafiltrate obtained in step 4 to an infusion bag for packaging with a peristaltic pump, seal it...

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Abstract

The invention discloses a refining method of ginkgo flavone and preparing method of ginkgo damo injection, which comprises the following steps: adding ginkgo extract in the dimidamo with pH value at 3.0-6.5, setting temperature at 100 deg.c to react, sedimenting at low temperature, hyperfiltering, sterilizing, adopting NaHSO3 as anti-oxidant.

Description

technical field [0001] The invention relates to a refining method of ginkgo total flavonoids and a method for preparing ginkgo damo injection. Background technique [0002] The total flavonoids of Ginkgo biloba is a kind of natural special medicine raw material, which is extracted and refined from Ginkgo biloba, which is abundant in my country. Widely used in medicine, nutritional health products and high-end cosmetics. [0003] Dipyridamole (also known as dipyridamole, dipyridamole, dipyridamole, piperidine, bipyridamole, parapyridamole) is an antiplatelet drug of choice. It has antithrombotic effect, it can inhibit the first phase aggregation and the second phase aggregation of platelets. High concentration (50ug / ml) can inhibit the release reaction of platelets. It can be used clinically for thromboembolic diseases. Dipyridamole is a yellow crystalline powder; odorless: slightly bitter taste, soluble in chloroform, soluble in ethanol, slightly soluble in acetone, almos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/16A61K31/519C07D311/30A61P9/10A61P7/02
Inventor 蔡南桂
Owner HUNAN SAILONG PHARMA
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