Technology for preparing salviae miltiorrhizae oral liquid with ceramic membrane

A preparation process and ceramic membrane technology, which is applied in the field of preparation of Danshen oral liquid, can solve the problems of incomplete removal of tannins, increased pollution, difficulty in adapting to modernization, etc., to solve the problem of clarity, reduce filtration resistance, and retain active ingredients Effect

Active Publication Date: 2014-01-08
江苏恒沣药业有限公司
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, along with the advancement of technology and the development of society, the above-mentioned preparations of Salvia miltiorrhiza have gradually exposed some defects in the preparation, which are difficult to control the clinical quality, unstable content, gradually darkening color, serious loss of active ingredients, tannin Incomplete removal affects clarity (clarity in traditional Chinese medicine oral liquid is a long-standing problem and is the main factor affecting the quality of traditional Chinese medicine oral liquid
The molecular weight of some impurities is mostly macromolecules with a molecular weight of 20,000 or more, while the active ingredients are mostly small molecules. It is difficult to effectively remove protein, tannin and other macromolecular impurities in the liquid medicine by ordinary filtration), and there is no effective removal method for protein , needs to consume a large amount of organic solvents during preparation, increases pollution, seriously affects the quality of products and other problems, thus seriously hindering the application and sales of products, restricting the demand for people's medicines, and it is difficult to adapt to modern and international Chinese medicine preparations requirements

Method used

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  • Technology for preparing salviae miltiorrhizae oral liquid with ceramic membrane
  • Technology for preparing salviae miltiorrhizae oral liquid with ceramic membrane
  • Technology for preparing salviae miltiorrhizae oral liquid with ceramic membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Take 1000g of Salvia miltiorrhiza, add water and decoct three times, the amount of water added is 10 times, 8 times and 6 times respectively, decocting for 2 hours for the first time, decocting for 1.5 hours for the second time, and decocting for the third time After 1.5 hours, the decoction was combined, filtered, concentrated to 6 times the amount of medicinal materials, and centrifuged at a high speed (18,000 rpm). The centrifugate was pre-filtered with a ceramic membrane with a molecular weight of 150,000. The residue was discarded, and the filtrate was collected for later use. The primary filtrate was filtered again with a ceramic membrane with a molecular weight of 120,000, the residue was discarded, and the filtrate was collected for later use. The fine filtrate is ultrafiltered with an ultrafiltration membrane with a molecular weight of 50,000, and the ultrafiltrate is concentrated with a nanofiltration membrane. The specification of the nanofiltration...

Embodiment 2

[0034] Example 2: Take 1000g of Salvia miltiorrhiza, add water and decoct three times, the amount of water added is 10 times, 8 times and 6 times respectively, decocting for 2 hours for the first time, decocting for 1.5 hours for the second time, and decocting for the third time After 1.5 hours, the decoction was combined, filtered, concentrated to 6 times the amount of medicinal materials, and centrifuged at a high speed (17,000 rpm). The centrifuged liquid was pre-filtered with a ceramic membrane with a molecular weight of 160,000. The residue was discarded, and the filtrate was collected for later use. The primary filtrate was filtered again with a ceramic membrane with a molecular weight of 100,000, the residue was discarded, and the filtrate was collected for later use. The fine filtrate is ultrafiltered with an ultrafiltration membrane with a molecular weight of 30,000, and the ultrafiltrate is concentrated with a nanofiltration membrane. The specification of the nanofilt...

Embodiment 3

[0038] Example 3: Take 1000g of Salvia miltiorrhiza, add water and decoct three times, the amount of water added is 10 times, 8 times and 6 times respectively, decocting for 2 hours for the first time, decocting for 1.5 hours for the second time, and decocting for the third time After 1.5 hours, the decoction was combined, filtered, concentrated to 6 times the amount of medicinal materials, and centrifuged at a high speed (15,000 rpm). The centrifugal liquid was pre-filtered with a ceramic membrane with a molecular weight of 180,000. The residue was discarded, and the filtrate was collected for later use. The primary filtrate was filtered again with a ceramic membrane with a molecular weight of 80,000, the residue was discarded, and the filtrate was collected for later use. The fine filtrate is ultrafiltered with an ultrafiltration membrane with a molecular weight of 30,000, and the ultrafiltrate is concentrated with a nanofiltration membrane. The specification of the nanofiltr...

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Abstract

A technology for preparing salviae miltiorrhizae oral liquid with a ceramic membrane is characterized by comprising the following steps of decoction, concentration, centrifugal filtration through a high-speed centrifuge, primary filtering by ceramic membrane with the hole diameter of 150000-180000 molecular weight, secondary filtering by ceramic membrane with the hole diameter of 80000-120000 molecular weight, ultrafiltration by ceramic membrane with the hole diameter of 20000-50000 molecular weight, nanofiltration concentration by ceramic membrane with the hole diameter of 300-450 nanometers, concentrating medicine liquid to the amount 2.5-3.5 times that of medicinal materials, final preparation and embedment sterilization. Heating processes in the whole technology course are reduced, ceramic membrane filtering with different molecular weights and refining under normal temperature are carried out, impurities are effectively removed, effective constituents are reserved to the maximum degree, an extracting technology is shortened, pollution is lowered, energy is saved, clean production is achieved, the technology accords with traditional Chinese medicine theoretical system, an ultrafiltration membrane filtering technology is used, degerming and pyrogen effect is good, and the clarity of medicine liquid is guaranteed and improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a process for preparing Danshen oral liquid by using a ceramic membrane. Background technique [0002] With the continuous improvement of living standards, especially my country's gradual aging society, the incidence and mortality of coronary heart disease are gradually increasing. Salvia miltiorrhiza has definite curative effect on the treatment of coronary heart disease, and the side effect is little, is a common medicine for coronary heart disease and cardiovascular disease. The latest research in the United States has found that the Chinese herbal medicine Salvia miltiorrhiza contains components that lower blood pressure, which may be used to develop new drugs for the treatment of high blood pressure. The root of Danshen is used in China to treat high blood pressure and heart disease. Animal tests have shown that it can lower blood pressure and dilate blood vessels...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537
Inventor 苏海波鲁湖勇
Owner 江苏恒沣药业有限公司
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