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Application of neuregulin 1

A technology of neuregulin and inflammatory pain, which is applied in the application field of neuregulin 1, can solve the problems of tolerance and addiction, and achieve non-addiction, clear targeting and significant curative effect

Pending Publication Date: 2020-04-03
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have different degrees and types of side effects, such as opioid analgesics can lead to tolerance and addiction and other problems

Method used

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  • Application of neuregulin 1
  • Application of neuregulin 1
  • Application of neuregulin 1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Experimental animals: 30 8-week-old male C57BL / 6, weighing 24±1g, purchased from the Experimental Animal Center of Sun Yat-sen University.

[0028] Specific Pathogen Free (SPF) animal center breeding, the temperature of the breeding area is generally between 25-28 ℃, the humidity is controlled between 40-70%, the automatic system controls the fluorescent lighting system, 12h / 12h light and dark automatically alternately. The animal center cleans regularly, replaces animal litter, and adds feed. Each mouse is raised in a single cage and can freely take in SPF-grade breeding grade feed and drinking water.

[0029] 2. Drugs: neuregulin 1 (NRG1 comes from PROSPEC), dissolved in 1% bovine serum albumin (BSA comes from GENVIEW); carrageenan (Carrageenan comes from Macklin), dissolved In physiological saline (NaCl comes from SIGMA).

[0030] 3. Equipment: electronic balance (from METTLER TOLEDO Instrument Co., Ltd.); rotating rod tester, spontaneous activity experimental equipmen...

Embodiment 2

[0038] 1. Experimental animals: 40 8-week-old male C57BL / 6, weighing 24±1g, purchased from the Experimental Animal Center of Sun Yat-sen University.

[0039] Specific Pathogen Free (SPF) animal center breeding, the temperature of the breeding area is generally between 25-28 ℃, the humidity is controlled between 40-70%, the automatic system controls the fluorescent lighting system, 12h / 12h light and dark automatically alternately. The animal center cleans regularly, replaces animal litter, and adds feed. Each mouse is raised in a single cage and can freely take in SPF-grade breeding feed and drinking water.

[0040] 2. Drugs: neuregulin 1 (NRG1 comes from PROSPEC); complete Freund's adjuvant (CFA comes from SIGMA); ecto-ErbB4 (cloned protein, containing the extracellular segment of ErbB4, can specifically inhibit NRG1-ErbB4 The role of signal activity, synthesized by the Guangdong Key Laboratory of Major Mental Disease Research, Southern Medical University).

[0041] 3. Experimental...

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Abstract

The invention relates to an application of neuregulin 1. Research finds that mechanical induced pain and hyperalgesia induced by carrageenan or a complete Freund's adjuvant can be obviously relieved by intrathecal injection of NRG1 into spinal cord, and the effect can be blocked by NRG1 neutralizing peptide (ecto-ErbB4) capable of specifically inhibiting activation of an ErbB4 tyrosine kinase receptor. Therefore, NRG1 can be applied to preparation of a medicine for treating or relieving inflammatory pain or can be applied to preparation of a medicine for activating the activity of ErbB4 tyrosine kinase expressed by spinal dorsal horn. The medicines have the advantages of clear targeting, safety, no addiction or other side effects, and obvious curative effect. The research of the inventionprovides a new treatment target and treatment scheme for the treatment of inflammatory pain.

Description

Technical field [0001] The invention relates to the technical field of medical applications, in particular to the application of a neuromodulin 1 (Neuregulin1, NRG1). Background technique [0002] Chronic pain is a common clinical symptom. Chronic pain in my country accounts for about 30% to 60% of outpatients in pain clinics, causing a huge economic burden on society and individuals (Medan, Review of Chronic Pain and Mood Disorders[J]. Clinical and Medical, 2013 (13): 473-474.). Especially in low- and middle-income countries, the prevalence of chronic pain is higher, with 33% of the adult population, 56% of the elderly, and 35% of workers (Jackson T, Thomas S, Stabilie V, etal. Prevalence of chronic pain in low-income and middleincome countries: asystematic review and meta-analysis. Lancet. 2015; 385: S10.). Chronic pain is closely related to a variety of inflammatory states, such as rheumatoid arthritis, inflammatory bowel disease, osteoarthritis and postoperative inflammation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61P29/00A61P25/00
CPCA61K38/185A61P25/00A61P29/00A61K38/18A61P25/02
Inventor 陈永君许能贵许云龙万超凡姚琳吴晓丽
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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