Application of zogta in preparation of drugs for enhancing anticancer activity of daunorubicin in vivo and in vitro
A technology of daunorubicin and anticancer activity, applied in the field of drug preparation, can solve the problems of increasing drug dose, reducing curative effect, failure of chemotherapy, etc., and achieve the effect of promoting enrichment, promoting apoptosis rate, and increasing drug concentration
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[0024] 1. Zotai promotes the entry of daunorubicin into cells
[0025] 1.1 Administration method
[0026] Grouping and administration: K562 leukemia cells, HN4 oral squamous cell carcinoma epithelial cells and HpG2 liver cancer cells were divided into daunorubicin alone 24h, 48h and 72h administration groups and daunorubicin combined with Zotai 24h, 48h and 72h administration group.
[0027] 1.2 Sample collection: Take K562 leukemia cells in logarithmic growth phase, HN4 oral squamous cell carcinoma epithelial cells and HpG2 liver cancer cells, and adjust the cell density to 2×10 6 Inoculated in Petri dishes respectively, placed in 5% CO 2 1. Cultivate in an incubator at 37°C until the cells grow to 70-80%. The three kinds of cells were treated with daunorubicin at a concentration of 0.25 μg / ml and Zotai combined with daunorubicin at a concentration of 5 ng / ml, washed three times with PBS after 24h, 48h, and 72h, and the cells were collected respectively.
[0028] 1.3 Samp...
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