cerna competition module identification method, device, electronic equipment and storage medium

Abstract

The invention provides a ceRNA competition module identification method, device, electronic equipment and storage medium, and relates to the field of gene identification. The ceRNA competition module recognition method includes: respectively according to the RNA 1 expression matrix and RNA 2 expression matrix to obtain RNA 1 Gene modules and RNA 2 gene module, where RNA 1 and RNA 2 are miRNA target genes. Based on a priori miRNA-target gene regulatory relationship data, miRNA expression matrix, RNA 1 Gene modules and RNA 2 The gene module identifies a ceRNA competition module that satisfies the conditions, wherein the ceRNA competition module includes an internal competition module and an external competition module. Due to the consideration of ceRNA internal and external competition, the strength of ceRNA internal competition and external competition was measured at the module level, as well as the influence of miRNAs on ceRNA internal and external competition. Therefore, the protocol provided by the present invention can accurately identify ceRNA competition modules.

Description

technical field [0001] The invention relates to the technical field of gene identification, in particular to a method, device, electronic equipment and storage medium for identifying a ceRNA competition module. Background technique [0002] Micro Ribonucleic Acid (miRNA) is a kind of non-coding small ribonucleic acid (Ribonucleic Acid, RNA) molecule. miRNA mainly affects the expression level of target genes by negatively regulating target genes. However, according to the endogenous competing RNA (competing endogenous RNA, ceRNA) hypothesis, target genes that share miRNA response elements (miRNA response elements, MREs) can also affect their respective gene expression levels through mutual competition. These target genes (including coding genes and non-coding genes) that share the same MREs and form a competitive relationship are collectively referred to as ceRNA or miRNA sponges. [0003] In the prior art, the application number CN201910684738.7 provides a method and devic...

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Problems solved by technology

[0005] The object of the present invention is to, aiming at the deficiencies in the above-mentioned prior art, provide a kind of ceRNA competition module recognition method, device, electronic equipment and storage medium, to solve the problem that the recognition method in the prior art cannot recognize ceRNA internal competition module

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