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Method for determining components of angelica sinensis pills (concentrated pills) by using quantitative analysis of multiple components by single marker

A technology of concentrated pills and angelica, applied in measuring devices, instruments, scientific instruments, etc., to achieve the effects of good repeatability, good stability and good durability

Pending Publication Date: 2020-08-07
河南省食品药品检验所
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Problems solved by technology

[0007] The purpose of the present invention is to provide a method for determining the composition of Angelica Pills (concentrated pills) by using the method of "one test and multiple evaluations". A cost-saving detection method for the three components of ferulic acid, ligustilide I and ligustilide in Danggui pills (concentrated pills)

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  • Method for determining components of angelica sinensis pills (concentrated pills) by using quantitative analysis of multiple components by single marker
  • Method for determining components of angelica sinensis pills (concentrated pills) by using quantitative analysis of multiple components by single marker
  • Method for determining components of angelica sinensis pills (concentrated pills) by using quantitative analysis of multiple components by single marker

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[0044] The present invention will be further described in conjunction with the following examples.

[0045]The present invention adopts the method for measuring the composition of Angelica Pills (Concentrated Pills) by using the method of one test and multiple evaluations. Relative correction factor (f) between, by described relative correction factor (f) calculate the content of ferulic acid, Ligustilide I, adopt liquid chromatography to measure, described method comprises the following steps:

[0046] Step S1: Chromatographic conditions and system suitability test

[0047] Column: CSH TM C 18 (4.6×250mm, 5μm);

[0048] Mobile phase A: acetonitrile;

[0049] Mobile phase B: 0.1% formic acid (B);

[0050] Gradient elution program:

[0051] 0~10min, A: 20%→58%;

[0052] 10~25min, A: 58%→68%;

[0053] 25~33min, A: 68%→68%;

[0054] 33~40min, A: 68%→95%;

[0055] 40~41min, A: 95%→20%;

[0056] 41~50min, A: 20%→20%;

[0057] Column temperature: 30°C; detection wavele...

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Abstract

The invention discloses a method for determining components of angelica sinensis pills (concentrated pills) by adopting a quantitative analysis of multiple components by single marker. According to the method, ligustilide is used as an internal reference substance to perform quantitative analysis of multiple components by single marker, a relative correction factor (f) between ligustilide and ferulic acid and senkyunolide I is established, the content of ferulic acid and senkyunolide I is calculated through the relative correction factor (f), and a liquid chromatography method is used for determination. The method is high in practicability, simple to operate, rapid and accurate in testing, cost-saving, good in repeatability, good in stability and good in durability, and provides a basis for establishing quality evaluation of the angelica sinensis pills (concentrated pills).

Description

technical field [0001] The invention relates to the technical field of quality detection of Chinese patent medicines, in particular to a method for measuring multiple components in angelica pills (concentrated pills) by using a method of one test and multiple evaluations. Background technique [0002] Danggui Pills (Concentrated Pills) are now included in the "Ministry of Health's Fifteenth Volume of Traditional Chinese Medicine Prescriptions". Its quality control method is relatively simple, and it only stipulates a microscopic identification of powder and determination of extracts, and lacks the common ones in the current Chinese Pharmacopoeia. The quality control method for the content determination of drug ingredients; the medicinal material of angelica was first recorded in "Shen Nong's Herbal Classic", known as "the holy medicine of the blood family", the function and indications of Danggui pills (concentrated pills) are nourishing and promoting blood circulation, regul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8679G01N30/8624G01N2030/045
Inventor 樊磊磊徐金玲宋汉敏张婷婷王雪芹陶明袁力
Owner 河南省食品药品检验所
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