Metaphase split-phase chromosome region searching method and device

A chromosome and region technology, applied in the field of medical images, can solve problems that affect the quality of detection results, ignore connections, and fail to realize automation

Inactive Publication Date: 2020-10-27
湖南品信生物工程有限公司
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Existing metaphase chromosome search methods are not truly automated and involve some manual intervention
In the thresholding segmentation process of images in the detection stage, parameters such as thresholds need to be set, and the adaptability to image data from different sources is poor
The selection stage relies on the manual feature extraction process, the quality of the classification results depends on the effectiveness of the feature design, and there are certain subj

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  • Metaphase split-phase chromosome region searching method and device
  • Metaphase split-phase chromosome region searching method and device
  • Metaphase split-phase chromosome region searching method and device

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Embodiment Construction

[0053] The following are specific embodiments of the application and in conjunction with the accompanying drawings, further describe the technical solution of the application, but the application is not limited to these embodiments. In the following description, specific details, such as specific configurations and components, are provided merely to help a comprehensive understanding of the embodiments of the present application. Accordingly, those of ordinary skill in the art should recognize that various changes and modifications of the embodiments described herein can be made without departing from the scope and spirit of the application. Also, descriptions of well-known functions and constructions are omitted for clarity and conciseness.

[0054] It should be noted that, in the case of no conflict, the implementations in the present application and the features in the implementations can be combined with each other.

[0055] figure 1 It is a flow chart of a method for se...

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Abstract

The invention provides a metaphase split-phase chromosome region searching method and device, and relates to the technical field of medical images. The metaphase split-phase chromosome region searching method comprises the following steps: acquiring a split-phase cell image; inputting the clipped division-stage cell image into a deep convolutional network; automatically completing a feature extraction process by the network, and further fusing the features of different levels; generating mid-metaphase chromosome region prediction results at multiple levels. According to the technical scheme provided by the invention, the efficiency and accuracy of searching for a metaphase chromosome region can be improved, and the method can be suitable for images in different shooting environments.

Description

technical field [0001] The present application relates to the technical field of medical images, in particular to a method and device for searching chromosome regions in metaphase. Background technique [0002] Chromosomal karyotype analysis is a common and important medical clinical diagnosis method. According to the chart results of karyotype analysis, chromosomal variation can be observed, thereby diagnosing various genetic diseases. When performing chromosome karyotype analysis, it is usually necessary to screen out a certain number of metaphase chromosome region images from a large number of chromosome cell images. If this process is all done manually by a geneticist, it will take a lot of time, and it will be easily interfered by the doctor's subjective judgment, which will affect the quality and accuracy of the karyotype analysis results. [0003] Aiming at various problems in the process of searching for chromosome regions in metaphase, many automatic searching met...

Claims

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Application Information

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IPC IPC(8): G16H30/00G06T7/11G06T7/00G06T5/50G06N3/08G06N3/04
CPCG16H30/00G06T7/0012G06T7/11G06T5/50G06N3/08G06T2207/10061G06T2207/20081G06T2207/20084G06T2207/30024G06T2207/20221G06N3/045
Inventor 梁毅雄刘浩天刘剑锋王慧
Owner 湖南品信生物工程有限公司
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