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Anti-coronavirus traditional Chinese medicine granules and preparation method and application thereof

A technology of traditional Chinese medicine granules and crowns, applied in the field of preparing said traditional Chinese medicine granules, treating coronavirus diseases, and traditional Chinese medicine granules, can solve the problem that no decoction or preparation method of decoction is disclosed, and it is inconvenient to transport, store, and administer dosage. It is difficult to determine and other problems, to achieve the effect of significant curative effect, low probability, and rapid nucleic acid conversion

Active Publication Date: 2020-11-06
SHANDONG BUCHANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is evidence that traditional Chinese medicine has played an important role in the treatment of new coronavirus pneumonia, such as the traditional Chinese medicine formula used to treat patients with new coronary pneumonia whose TCM syndrome is manifested by dampness and stagnation in the lungs. However, the prior art does not disclose the decoction or preparation method of the decoction, nor does it disclose whether the formula has an effect on other coronaviruses other than the new coronavirus
In addition, traditional Chinese medicine decoctions have many disadvantages, such as inconvenient transportation and storage, and difficult to determine the dosage
[0005] Therefore, there is an unmet need for traditional Chinese medicine granules that can effectively treat coronavirus diseases, such as novel coronavirus pneumonia

Method used

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  • Anti-coronavirus traditional Chinese medicine granules and preparation method and application thereof
  • Anti-coronavirus traditional Chinese medicine granules and preparation method and application thereof
  • Anti-coronavirus traditional Chinese medicine granules and preparation method and application thereof

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Experimental program
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preparation example Construction

[0089] In a preferred embodiment of this aspect, the preparation method comprises the following steps:

[0090] (1) Put raw gypsum in 10 times the amount of water or alcohol aqueous solution to extract for 30 minutes, then add ephedra, bitter almond, coix seed, atractylodes rhizome, knotweed, verbena, reed root, Tinglizi and Huajuhong, and use 10 times the amount Extract with water once or twice, each time for 1 hour, filter, and combine the filtrate during the two extractions to obtain the first filtrate, and the dregs are directly used in the next step;

[0091] (2) Add Artemisia annua and Patchouli to the medicinal dregs, extract once or twice with 3 to 10 times the amount of water, each time for 10 to 80 minutes, filter, and combine the filtrate when extracting twice to obtain the second filtrate;

[0092] (3) combining the first filtrate and the second filtrate, concentrating to obtain the first concentrated solution;

[0093] (4) Put the licorice root in 3 to 15 times t...

Embodiment 1

[0113] Preparation of Chinese medicine granules of the present invention

[0114] Recipe composition:

[0115] Ephedra 150g, Bitter Almond 375g, Gypsum 750g, Coix Seed 750g, Atractylodes 250g, Patchouli 375g, Verbena 750g, Polygonum cuspidatum 500g, Reed Root 750g, Tinglizi 375g, Huajuhong 375 grams, Artemisia annua 300 grams and licorice 250 grams.

[0116] Preparation of active extract of traditional Chinese medicine:

[0117] The above thirteen flavors are decocted with licorice alone, and the rest of the medicinal flavors are first extracted with gypsum in ten times the amount of water or alcohol solution for 30 minutes. Filter the filtrate, add Artemisia annua and Huoxiang to the dregs, then add six times the amount of water to extract for 30 minutes, combine the extracts, and concentrate below 60°C; add 10 times the amount of water to extract licorice twice, each time for one hour, and concentrate the filtrate to an appropriate amount The relative density of the combi...

Embodiment 2

[0121] Preparation of Chinese medicine granules of the present invention

[0122] Recipe composition:

[0123] 240 grams of ephedra, 600 grams of bitter almonds, 1,200 grams of raw gypsum, 1,200 grams of coix seed, 400 grams of herb, 600 grams of patchouli, 1,200 grams of verbena, 800 grams of knotweed, 1,200 grams of reed root, 600 grams of Tinglizi, and orange red 600 grams, 480 grams of Artemisia annua and 400 grams of licorice.

[0124] Preparation of active extract of traditional Chinese medicine:

[0125] Take the indicated amount of decoction pieces (except licorice) in each batch, decoct twice, add 10 times the water once decocting, first decoct raw gypsum for 30 minutes, then decoct other herbs (except artemisia annua and patchouli) for 60 minutes, Filter to obtain the first decoction extract, add Artemisia annua and patchouli, add 6 times the water along with the first decoction residue, decoct the second decoction for 30 minutes, filter the extract through a 250-m...

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Abstract

The invention relates to anti-coronavirus traditional Chinese medicine granules and a preparation method and application thereof. The anti-coronavirus traditional Chinese medicine granules comprise atraditional Chinese medicine active extract composed of separately extracted first extract and second extract, wherein the first extract is a water or alcohol-water extract of herba ephedrae, semen armeniacae amarum, gypsum fibrosum, semen coicis, rhizoma atractylodis, herba pogostemonis, rhizoma polygoni cuspidati, herba verbenae, rhizoma phragmitis, semen lepidii, exocarpium citri grandis and herba artemisiae annuae; the second extract is a water or alcohol-water extract of radix glycyrrhizae; and each 10 g of granules contain not less than 2.3 mg of ephedrine hydrochloride and pseudoephedrine hydrochloride, not less than 42.7 mg of naringin and not less than 7.7 mg of glycyrrhizic acid. The traditional Chinese medicine granules provided by the invention can be used for treating a coronavirus disease.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, in particular to traditional Chinese medicine granules, which can be used to treat coronavirus diseases, such as novel coronavirus pneumonia (COVID-19). The present invention also relates to a method for preparing the traditional Chinese medicine granules, and the use of the traditional Chinese medicine granules for treating coronavirus diseases. Background technique [0002] Coronaviridae viruses are a large group of viruses that widely exist in nature and infect vertebrates, such as humans, mice, pigs, cats, dogs, wolves, chickens, cattle, and birds. The new coronavirus (SARS-CoV-2) belongs to the β-coronavirus in the Coronaviridae family, and its genetic characteristics are significantly different from those of SARSr-CoV and MERSr-CoV. The virus is sensitive to ultraviolet rays and heat, and lipid solvents such as 56°C for 30 minutes, ether, 75% ethanol, chlorine-containing disinfe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K9/16A61K47/26A61P31/14A61K33/06
CPCA61K36/17A61K36/736A61K33/06A61K36/8994A61K36/284A61K36/532A61K36/704A61K36/85A61K36/899A61K36/31A61K36/752A61K36/282A61K36/484A61P31/14A61P11/00A61K2300/00Y02A50/30
Inventor 张伯礼刘清泉高秀梅张俊华宋新波张磊王毅杨丰文郑文科王涛王跃飞张晗黄宇虹王苹刘二伟刘岱琳张静泽黄明
Owner SHANDONG BUCHANG PHARMA
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