Quinoline compound for combined treatment on breast cancer

A breast cancer, compound technology, applied in the field of quinoline compounds or their pharmaceutically acceptable salts, can solve problems such as toxic and side effects

Pending Publication Date: 2020-12-08
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The commonly used chemotherapeutic drugs for breast cancer are cyclophosphamide, 5-fluorouracil, methotrexate, doxorubicin, epirubicin, mitomycin, vincristine, vinblastine, and cisplatin. In consideration of drug resistance and therapeutic effect, the current breast cancer chemotherapy mostly uses a combination of three or more drugs, which improves the efficiency, but also leads to strong toxic and side effects.

Method used

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  • Quinoline compound for combined treatment on breast cancer
  • Quinoline compound for combined treatment on breast cancer
  • Quinoline compound for combined treatment on breast cancer

Examples

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Embodiment Construction

[0144] The following is to further illustrate the present invention in conjunction with specific embodiments and experimental examples. However, these examples are only for illustrating the present invention and are not used to limit the scope of the present invention. For the experimental methods that do not indicate specific experimental conditions in the following examples, follow the conventional conditions.

[0145] In patients with pathologically confirmed recurrent or metastatic triple-negative breast cancer with measurable disease and disease progression after at least prior anthracycline and / or taxane therapy, co-administration of anlotinib Ni and capecitabine. The specific administration method is as follows:

[0146] Capecitabine tablets: 1000mg / m 2 , 2 times a day, within 30 minutes after a meal, take orally for 2 weeks and stop for 1 week, that is, 3 weeks (21 days) is a treatment cycle, until the disease progresses or the adverse reactions are intolerable;

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Abstract

The application belongs to the technical field of medicines, provides a quinoline compound for combined treatment on breast cancer and particularly provides use of combination of a compound I or pharmaceutically acceptable salts thereof and a second therapeutic agent in preparation of drugs for treating the breast cancer and a combined pharmaceutical composition for treating the breast cancer. Thecombined pharmaceutical composition comprises: (i) the compound I or pharmaceutically acceptable salts thereof; and (ii) at least one second therapeutic agent, wherein a chemical name of the compoundI is 1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinol-7-yl]oxy]methyl]cyclopropylamine.

Description

technical field [0001] The invention belongs to the field of medicine, and the invention belongs to the technical field of pharmaceutical preparations, specifically a quinoline compound or a pharmaceutically acceptable salt thereof for combined treatment of breast cancer. Background technique [0002] Breast cancer is one of the most common malignant tumors in women all over the world. Female mammary glands are composed of skin, fibrous tissue, mammary glands and fat, and breast cancer occurs in mammary glandular epithelial tissue. Since the mammary gland is not an important organ to maintain human life activities, breast cancer in situ is not fatal, but free cancer cells can spread throughout the body with blood or lymph fluid, and easily metastasize in lungs, liver, bones, brain and other organs, destroying Its normal tissue is life-threatening. According to statistics from the International Agency for Research on Cancer (IARC) of the World Health Organization, there are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/4709A61K31/675A61K31/704A61K31/337A61K31/513A61K33/243A61K31/519A61P35/00A61P35/04
CPCA61K45/06A61K31/4709A61K31/675A61K31/704A61K31/337A61K31/513A61K33/243A61K31/519A61P35/00A61P35/04A61K2300/00
Inventor 王善春袁芃岳健
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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